Department of Immunobiology at UNIL
@DIB_UNIL
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Official account of the department of immunobiology (DIB) at the university of Lausanne @UNIL. Formerly department of biochemistry.
Lausanne
Joined April 2022
Postdoc position in the Jourdain Lab!
2 weeks left to apply to the postdoc position in our lab AND we are extending the call to 2 topics! ➡️ nucleotide metabolism in #immunometabolism and #cancer in vivo ➡️ mitochondrial RNA granules in #innate_immunity Same link: @FBM_UNIL @mitojobs
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New preprint from @AlexandraBoegli and @broz_lab !
Happy to announce the first preprint of my PhD 🥳 We show that the inflammasome receptor NLRP6 is activated by sterile or pathogen induced endolysosomal damage. Thanks to all the coauthors of the study @EBernard1993 and @broz_lab, including twitterless Louise, Gaël and Vanessa
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Excited to share our latest paper out today in @NatureComms! Great work led by postdoc @AlesDrobek showing for the first time the critical role in vivo of the SLC15A4/TASL/IRF5 pathway that we discovered few years ago. #innateimmunity #autoimmunity
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Postdoc position available in the Jourdain Lab!
📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! Please share #uridine #cancermetabolism #immunometabolism
@FBM_UNIL @unil 🔗(PDF):
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Funded postdoctoral position available in the Jourdain Lab!
📢We're recruiting📢 Our lab at the University of Lausanne is looking for a postdoctoral associate to study #nucleotide metabolism in physiology and cancer in vivo! #uridine #cancermetabolism #immunometabolism
@FBM_UNIL @FBM_UNIL @DIB_UNIL 🔗(PDF):
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Very happy to share our latest work just published in @JExpMed! Our amazing PhD student @BernaleauL shows that CCDC134 controls TLR biogenesis through the ER-chaperone Gp96.
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New manuscript by Sina Bohnacker and @JuliaEsservB published in Science Immunology!
Decoding Worm Strategies to Advance Vaccines and Therapies 🧬 👉 A study led by Prof. Julia Esser-von Bieren and Dr. Sina Bohnacker, #HelmholtzMunich, @TU_Muenchen, and @unil, reveals how worm parasites (#helminths) evade immune defenses by manipulating #macrophages using a protein called #heGDH. 💡This discovery paves the way for innovative vaccines and therapies targeting infectious diseases, allergies, and asthma. 🌍 With 24% of the global population affected by helminths, this research could address major infectious and immune-related challenges worldwide. 💬 “Our findings could lead to transformative treatments for infectious diseases and inflammatory conditions like asthma.” - Prof. Esser-von Bieren 🌟The study, published in @SciImmunology, even earned a coveted spot on the cover! 🎉 Additionally, Dr. Sina Bohnacker was recently awarded the HELENA Doctoral Researchers Award by @Health_talents for her doctoral thesis on this subject. Congratulations! @JuliaEsservB @sina_bohnacker @ZAUMpollen @ScienceMagazine @DIB_UNIL @aaas
#Macrophage #Vaccines #Immunology #ImmuneDefense #ImmuneEvasion #GlobalHealth #Therapy #Allergy #Asthma #Infection #Research #Science
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RT @EBernard1993: Hot off the press, check out our News & Views on recent work from @dixitvishva @IshanDeshpande showing how NINJ1 is held…
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RT @IshanDeshpande: An excellent summary by @EBernard1993 and @broz_lab , contextualizing our recent work.
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Did you know that NINJ1 exists as an autoinhibited dimer in the PM of cells? In a @NatureNV @EBernard1993 and Petr describe new results from @dixitvishva and @IshanDeshpande, including a resting structure of NINJ1 with 3 helices! Check it out here:
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Groups of: Petr Broz @broz_lab Peter Darber @PeterDraberLab Julia Esser-von Bieren @JuliaEsservB Alexis Jourdain @jourdainlab Sanjiv Luther Fabio Martinon @fabiomartinon Andreas Mayer Manuele Rebsamen @RebsamenLab Pascal Schneider Margot Thome-Miazza
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An image from postdoc Emeline Recazens on the cover of PNAS! This picture highlights the recent @jourdainlab @DIB_UNIL publication led by M. Foged on the role of mitochondrial RNA granules in innate immunity.
Stressed mitochondrial RNA granules from our recent work on the cover of @PNASNews! A photo by E. Recazens illustrating our new story led by M. Foged on the cytosolic control of mitochondrial RNA processing and innate immunity by #N6AMT1. #mitochondria #dsRNA @FBM_UNIL
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New manuscript by M. Foged and @jourdainlab in @PNASNews! The authors discovered a pathways that coordinates the expression of the mitochondrial and nuclear genomes, and how dysfunction in this pathway leads to mitochondrial defects and #innate_immunity #dsRNA. @FBM_UNIL
Our story on a novel pathway that controls #mitochondria from the 𝐜𝐲𝐭𝐨𝐬𝐨𝐥 and influences #immunity is now peer-reviewed and available at @PNASNews! By M. Foged @DIB_UNIL @FBM_UNIL @MuenchLab @VamsiMootha #N6AMT1 #mtDNA #RNA_processing A recap 🧵
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Two new pre-prints from @broz_lab! 2/2
In a second preprint, postdoc @EHartenian and lab member Magalie show that NINJ1 is a restriction factor for HSV-1 in mouse macrophages We see that NINJ1 -/- cells are more infected than WT controls
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Two new pre-prints from @broz_lab! 1/2
The lab's latest NINJ1 story is out on @biorxivpreprint 🥳 Ninjurin-1 mediated plasma membrane rupture is a two-step process requiring cell swelling
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RT @broz_lab: The lab's latest NINJ1 story is out on @biorxivpreprint 🥳 Ninjurin-1 mediated plasma membrane rupture is a two-step process r…
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A direct link to the recent work from @miriamlisci and @jourdainlab 👇🏻 FBXW7 alleviates c-MYC repression of pyruvate carboxylase to support metabolic flexibility
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RT @jourdainlab: The direct link to our recent pre-print FBXW7 alleviates c-MYC repression of pyruvate carboxylase to support metabolic f…
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