Cornelius Gati
@CorneliusGati
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Structural biologist studying biophysics and pharmacology of human membrane proteins (GPCRs & Transporters). Assistant Professor @USC.
Los Angeles, CA
Joined December 2015
Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:G protein complexes. We show this at kappa-opioid receptors by cellular, radioligand binding and cryoEM studies. A 🧵: @USC @USCDornsife
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RT @taabaman: Really looking forward to hosting Dr. Derek Abbott for tomorrow's Raiziss seminar. Don't miss it! @BMBGGUPENN @PennMicro @Pen…
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RT @MassalyNiko: Great review from @RenataMarchette Leandro Vendruscolo and George Koob on Dynorphin/KOR system in substance use disorders…
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RT @unitmporg: Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes. @nchembio Check the #cryoEM #structure of…
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RT @CorneliusGati: Excited to share our work on GPCR antagonism: Contrary to popular belief, inverse agonists can bind to and act via GPCR:…
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RT @nchembio: A platform for the continuous selection of protein aggregation inhibitors from genetically encoded cyclic peptide libraries i…
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RT @MemProtPDB: Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes | Nat Chem Biol
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RT @nchembio: A new paper uncovers that certain κ-opioid receptor inverse agonists form receptor-G protein complexes, even in inactive stat…
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@peptide_drugs @MarcoNiello @USC @USCDornsife Yes, I've just submitted my abstract. I'm looking forward to catching up in person!
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RT @oxkawaka: Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes GPCRの定常活性を抑え込むインバース���ゴニスト、これまで不活性型フォームでGタンパ…
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RT @MatthewEddyLab: New review article in @NatRevDrugDisc on Functional Dynamics of GPCRs, based on discussions from a great CECAM GPCR mee…
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RT @raintank2010: Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes the canonical m…
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RT @AppuKSingh_IITK: @CorneliusGati @USC @USCDornsife Congratulations Gati! and team, wonderful work and amazing structures!
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RT @JGarciaNafria: Superb work! Simultaneous antagonist and G protein bound GPCRs!! Loads to understand still! Congrats @CorneliusGati and…
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Thank you so much, Javier! Hope all is well, and we cross paths again, soon.
Superb work! Simultaneous antagonist and G protein bound GPCRs!! Loads to understand still! Congrats @CorneliusGati and team!
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RT @sushmajumdarlab: Beautiful work by the Gati group on kappa opioids where we played a small role. Good start to 2025. More big ones comi…
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