Victor Corces
@CorcesVictor
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Joined October 2018
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@Anders_S_Hansen @DomenicNarducci @deWitLab @hansen_lab @GRO_Broad @kochinstitute @MITdeptofBE It may be worth doing one of those old fashion westerns running CTCF on a gel and probing with the Znf143 antibody to see if it really cross-reacts. Just in case all the indirect evidence has an alternative explanation
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@cshperspectives It looks like they used an antibody from a different company than at least some of the previous papers. Even if it was from the same company, maybe previous batches didn't cross react. In previous manuscripts, only a subset of ZnF143 sites overlap with CTCF.
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This is a must-read paper for those interested in chromatin 3D organization. Compartments are way smaller than generally thought
It's been a while since I posted. Pleased to announce 2 papers! Both about chromatin compartments. Using deep sequencing in collaboration with ENCODE, we identify A and B compartments at 500 bp resolution! #3Dgenome @NatureComms Out today: See Thread.
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@StearnsLab @eLife At least you know it's going to be accepted and can list it as in press, right? 😊
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@dphansti You should change the title of the paper to "If you need to draw black lines to show people where the domains are, then you need to sequence more"
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We have an exciting program with amazing speakers and lots of room for talks selected from the abstracts!!!!!
Only 3 weeks left to sign up for the #GenomeArchitecture #GRS if you would like to be considered for an oral presentation! We welcome all #PhD students and #Postdocs interested in #Chromatin biology! Deadline is March 5th! #GRC
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On the origin of the integrity of a subset of Topologically Associating Domains upon Cohesin loss in Interphase Chromosomes More proof that there are two types of TADs forming by different mechanisms. Using "TAD" to refer to both of them is confusing.
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3/ The right way for you to show that the results are due to cfDNA is to purify 100,000 sperm, isolate the cfDNA from this prep, and then do ATAC-seq or Hi-C. What do you see? Probably nothing because there is not enough cfDNA
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Maybe you are not purifying the sperm properly? We don't find any cell free DNA in sperm preps from the cause epididymis and no differences between treating or not with DNase. Also, no difference with ejaculated sperm after gradient purification
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@dacolon I think they were called Indians because Columbus thought he had arrived to the Indies. I don't think anyone from Spain at the time had ever seen a person from India
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