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Carlos E Alvarez Profile
Carlos E Alvarez

@CarlosEAlvare17

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873
Following
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I study complex genetics & molecular pharmacology. Interests include canine-human comparative genomics of behavior, cancer & pleiotropy; & alpha arrestins.

Columbus, OH
Joined August 2020
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@CarlosEAlvare17
Carlos E Alvarez
2 months
@NicoleCRust @doristsao @UCBerkeley My suggestion is first seeing if behavior is sufficiently considered in neuroscience & evolution sufficiently exploited. When I say we need more data (eg, developmental or longitudinal), I’m looked at like a fish from another tank & scolded, “We have the data, just need models!”
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@CarlosEAlvare17
Carlos E Alvarez
1 hour
@OmicsOmicsBlog I think cutting those costs from the NIH budget would be problematic at least for awards already made, because they are Congressional appropriations. The NIH announcement is consistent with this. This is the final section of the announcement; the last sentence is a zinger.
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@CarlosEAlvare17
Carlos E Alvarez
4 hours
RT @AdrianoAguzzi: CellTiterGlo is the universe's 3rd-worst+priciest reagent, so my postdocs invented a CNN-based software to count adheren…
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@CarlosEAlvare17
Carlos E Alvarez
4 hours
Since we’re talking about NIH reforms, can anyone point to discussion on whether the original intent of the INTRAmural program continues to be justified? Or is it now considered more of an elite national institution like the Blue Devils or "Frecce Tricolori" are for air shows.
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@CarlosEAlvare17
Carlos E Alvarez
4 hours
@katclone It’s not clear to me how significant and stable funding could be achieved. Some pharma sponsor academic institutions for first right of refusal of discovery. Also, states, fed, & industry fund ‘research incubators’ to stimulate creation of new businesses.
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@CarlosEAlvare17
Carlos E Alvarez
6 hours
RT @eLife: An imaging system with an ultra-wide field of view allows scientists to track millions of cells at once in large 3D tissues and…
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@CarlosEAlvare17
Carlos E Alvarez
6 hours
RT @eLife: Driver lines for studying associative learning in #Drosophila.
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@CarlosEAlvare17
Carlos E Alvarez
6 hours
@hubermanlab @NIH This seems misleading by suggesting the arguably poor progress would be mitigated by favoring translational research. I think the opposite is true, that the past several decades served to make translational research get a bigger & bigger share of the research pie over basic.
@CarlosEAlvare17
Carlos E Alvarez
1 day
The irony is that for the last ~25 years, university medical centers have been financially sustained largely by NIH translational grant funding - taking larger & larger shares of the pie shared w basic research (see note on critical evaluation of the justification/results). 3/
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@CarlosEAlvare17
Carlos E Alvarez
7 hours
@cremieuxrecueil Maybe but in fact it can be sincere mistake. ☺️ My favorite scientist to work with used to say ‘in fact’ about once a minute. I eventually pointed it out, and she never did it again. 😇 Funny how awkward it is to mention distracting habits. 😰
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@CarlosEAlvare17
Carlos E Alvarez
8 hours
@animewife4life @cremieuxrecueil That’s enough about me, how do you like my new haircut? (Maybe from SNL??) 😆
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@CarlosEAlvare17
Carlos E Alvarez
8 hours
Coming on the heels of the tariff crises & being untenable for all intents & purposes, the NIH indirects crisis would appear to be an opening negotiating position. Should we biomed researchers just argue it’s untenable & malicious, or is there a better way to appeal to voters?
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@CarlosEAlvare17
Carlos E Alvarez
9 hours
Where is the expert legal discussion of the NIH indirects crisis? Does the intent and letter of the 2017/2024 laws block the 15% cap or is it a reasonable or possible ‘loophole’ to the courts?
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@CarlosEAlvare17
Carlos E Alvarez
10 hours
@unreal_dave @AdrianoAguzzi Yes, but managers are ultimately responsible. They cannot risk failure or being responsible in that worst case. Thus they set up conditions for assigning responsibility to the 20% responsible for 80% of productivity. The meeting is a ritual to appear like reasoned deliberations.
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@CarlosEAlvare17
Carlos E Alvarez
10 hours
@GRCinemaTicket Jacques Tati’s marvelous Playtime is among the best depictions of the office being like a research colony of mice.
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@CarlosEAlvare17
Carlos E Alvarez
10 hours
@StephenORahilly I’ve been thinking there’s great potential for hum molecular epidemiology of insulin sensitivity in GLP-1 Rx obesity: starting with longitudinal metabolomics, & genetics. What correlates w insulin sensitivity in individual humans becoming, being, & reversing type 2 diabetes? No?
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@CarlosEAlvare17
Carlos E Alvarez
1 day
RT @srikosuri: It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendr…
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@CarlosEAlvare17
Carlos E Alvarez
1 day
But constructive criticism & philosophy are not enough. There needs to be critical evaluation of results and possible solutions must be discussed and the best of them undertaken. Here are some of my 5 cents on whether neuroscience is on the right track. 5/END
@CarlosEAlvare17
Carlos E Alvarez
24 days
Thanks. One might interpret your first tweet as suggesting there is no need to evaluate the course of mental health research over the past few decades. I don't think that's supported by 'on the verge' advances & animal studies were suggested to be conducted 'carefully'. 1/
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