How NCI's cancer-focused national lab is stepping up to validate
#COVID19
serological tests, uncover genetics of severe disease and find covalent inhibitors of viral proteins
With ALS action plan,
@US_FDA
aims for patient engagement, but
#ALS
advocates such as
@iamalsorg
's
@bsw5020
say the blueprint lacks urgency, noting that the agency’s timeline exceeds the life expectancy of most current patients
Rising serial entrepreneur Akiko Iwasaki has shown that increasing lymphatic drainage in the brain can prime immune responses to clear brain tumors. The work could lead to third cancer start-up out of
@VirusesImmunity
's lab this year.
ICYMI: Formed by
@kiranshaw
, Kush Parmar and
@DrSidMukherjee
, Bangalore's Immuneel plans to bring a
#CART
therapy to cancer patients in India for about $50K per treatment
ICYMI: The last two decades of drug approvals suggest the
#RuleofFive
is losing its grip on medicinal chemistry. Is it time to abandon the concept of "drug-like properties"?
@Novartis
@abbvie
Into
#NKcells
before they were cool:
@affimed
's long journey to find the right settings and combinations for its innate cell engager bispecifics is finally getting investors' attention; story from
@StephenPHansen
in
@BioCentury
Bob Nelsen, co-founder of Arch Ventures Partners, on AI creating a "language of biology," responding to the China challenge, and focusing on big opportunities.
Luciana Borio (
@llborio
) joins Arch as venture partner, brings expertise, FDA, White House experience in biodefense and public health and will focus on manufacturing, clinical trials, novel therapies. Firm promotes Carol Suh to partner
Kymera's latest Ph I data shows its IRAK4 protein degrader KT-474 reaches 96% degradation and inhibits induction of eight pro-inflammatory cytokines $KYMR
ICYMI: In a Guest Commentary,
@ScottGottliebMD
says
@US_FDA
is “on the cusp of a major cultural shift” that will transform the way the agency reviews drugs.
Merck acquires Calporta for up to $576 million, one of eight companies from the $GSK-Avalon Ventures' 2013 build-to-buy deal. Calporta is developing
#TRPML1
agonists for lysosomal storage and neurodegenerative disorders like
#alzheimers
and
#parkinsons
.
@atlasventure
's Bruce Booth sees biotech's belt-tightening starting to yield more favorable financing environment, but there's still pain to come. + how new modalities will play out. Watch
@LifeSciVC
in conversation
@BioCentury
's
@FishburnSimone
Orbital: an RNA toolbox for vaccines and protein replacement with technology from
@Stanford
and
@BeamTx
, and backed by Arch. An Emerging Company Profile by BioCentury's Richard Guy
@NTAPGuy
Ocrevus, an injectable, has overturned the "small molecule is better" paradigm in MS. What does that mean for the next drugs coming to market? $NVS $CELG
Hereditary angioedema proves to be an ideal proof-of-concept indication for in vivo gene editing from
@intelliatx
with new NTLA-2001 supporting a clear dose response in gene expression and near flawless clinical efficacy in first 10 patients
How new
@Medicxi
company Divide & Conquer, co-founded by
@sciencescanner
, aims to capitalize on new biology that could prevent cancer cells from sharing resistance mechanisms via multicellular networks
#ALS
patients are demanding greater regulatory flexibility from FDA that would enable broader access to therapies in the clinic. Doing so could generate a wealth of data
@iamalsorg
@alsassociation
BioCentury's
#ASCO18
abstract roundup suggests that away from the PD-1 herd, researchers are trying many new strategies, modalities and targets to solve big problems in cancer
Anti-China bills portend massive blow to biotech. According to a BioCentury survey, an overwhelming majority of biotechs expect pipeline setbacks; many oppose BIO’s reversal
Gilead's antiviral remdesivir almost completely resolved the symptoms of a U.S. patient infected with the coronavirus; now the biotech is planning a Chinese trial $GILD
#2019nCov
ICYMI:
@MIT
Professor Christopher Love's latest foray into benchtop manufacturing of biologics has yielded the InSCyT system, which produces clinical-quality proteins in just three days, suggesting it is nearly ready for industry use.
Remembering Fred Frank, a giant of biotech:
@jmaxlevin
,
@ps_onlyconnect
pay tribute to Frank, investment banker and early architect of the biotech industry
Drive-by analysis of accelerated approval is intellectual malpractice. Medical journals and news publications have incorrectly concluded that half of cancer accelerated approvals are useless. BioCentury's
@steveusdin1
explains why.
The latest revival of 38-yr-old $CLDX comes on the back of urticaria program CDX-0159, with Ph Ib data presented at
#EAACI2021
showing 95% complete response rate.
@StephenPHansen
speaks with
#Celldex
CEO Anthony Marucci and CSO Tibor Keler
.
@biogen
may have called off trials of aducanumab, but the amyloid hypothesis of Alzheimer's disease lives on.
@BioCentury
's
@SelinaMKoch
asks companies what data could make them walk away.
The Quiet Disrupters: How a technology to encode mAbs in RNA or DNA is quietly growing, with the potential to upend the standard way biologics are manufactured.
A trial funded by
@CureDuchenne
,
@MDAorg
and
@ParentProjectMD
aims to solve the AAV redosing problem. If successful, it could have major impact on patient care and gene therapy pipeline strategies.
Congrats to the 2019 BayHelix China Healthcare Award winners, announced last week during the 6th BioCentury-BayHelix China Healthcare Summit in Shanghai. $BGNE $AMGN $FGEN $ZLAB
Trading of Everest's shares is to begin Friday in Hong Kong after the mainland China company priced what could become the biggest IPO yet since
@HKEXGroup
opened its biotech chapter in 2018
.
@JMaraganore
talks to
@FishburnSimone
on The BioCentury Show about the convergence of an innovation explosion and a rising bar for investment, and why that's good for biotech. Plus, views on the Inflation Reduction Act, Biosecure Act, and more.
Gap in early stage funding for antibiotics companies leads
@NovoHoldings
to launch $165M REPAIR Impact Fund to invest in antimicrobial resistance plays
New CAR designs at
#ASH18
: BioCentury's infographic highlights CARs designed for multi-antigen targeting, overcoming PD1 and boosting tumor homing, and shows where to find them.
Formed by
@kiranshaw
, Kush Parmar and
@DrSidMukherjee
, Bangalore's Immuneel plans to bring a
#CART
therapy to cancer patients in India for about $50K per treatment
BioCentury launches free
#COVID19
Resource Center for the biomedical community to aid in the development of
#coronavirus
countermeasures and to help companies navigate the business impacts during the crisis
.
@healx
has an AI-based platform to repurpose drugs for rare disease and is building the patient voice into its discovery process. The $56M series B round the U.K. company raised Wednesday will help bring its
#FragileXSyndrome
into the clinic
As
@CEPIvaccines
looks to prepare for the next pandemic, it has set a lofty goal to reduce to 100 days the time from sequencing the pathogen to a regulatory submission of a vaccine. But, what will it take?
EXCLUSIVE: Gottlieb’s Exit Interview. Just days after his resignation,
@ScottGottliebMD
talks with BioCentury’s
@steveusdin1
about what he's done, what he thinks was most important, and what will carry forward. (Read with subscription or trial sub.)