Advancing countermeasures against 21st century health threats by bringing together public private partnerships and advancing innovation. Part of HHS/ASPR.
Today as BARDA enters our 16th year, we're releasing a new strategic plan focused on fortifying the nation’s
#HealthSecurity
by enabling a rapid response to
#PublicHealth
emergencies with
#MedicalCountermeasures
that save lives. Learn more:
Today, we took steps to speed the development and secure domestic manufacturing of two vaccines – one by
@Moderna_tx
& another by
@JanssenUS
- to prevent the spread of
#COVID19
and protect people at home and abroad.
Under
#ProjectNextGen
, we’re advancing the clinical development of next generation COVID-19
#vaccines
that offer broader, longer lasting protection & that are easier to administer & reduce viral spread. This
#NationalVaccinationDay
, learn more:
The
@T2Bio
T2Biothreat Panel is the newest
@US_FDA
clearance of a BARDA-supported product. This molecular diagnostic test runs on the T2Dx instrument and detects & differentiates between 6 biothreat pathogens in a single sample. Learn more:
Under
#ProjectNextGen
, we are partnering with
@Vaxart
on planning a Phase 2b clinical trial that would compare its oral pill
#COVID19
vaccine candidate to a currently approved COVID-19 vaccine. Learn more about Project NextGen:
Mucosal vaccines may have the potential to help prevent infection and transmission of COVID-19. Check out the latest
#BARDAResearch
to learn about progress in development & remaining challenges in getting vaccines to licensure:
BARDA is committed to supporting the next generation of innovative vaccine & therapeutic investments to help protect our nation against coronavirus and other infectious diseases.
We are joining forces with Tangen Biosciences to develop a fast, accurate, point-of-care molecular diagnostic test for use on the Tangen GeneSpark molecular diagnostic system to aid in diagnosing
#COVID
-19.
A Bluetooth-enabled, 60-second, point-of-care
#COVID19
diagnostic test that could help clinicians to more quickly and effectively diagnose patients is being developed through a partnership between BARDA and
@hememics
.
We’re excited about Project NextGen which supports vaccine innovation efforts to enhance efficacy & accessibility of vaccines for future pathogens with pandemic potential – they will ideally be developed faster, easier to transport, & cost less compared to current vaccines.
Today, we purchased a supply of
@Amgen
’s Nplate, a drug to combat the effects of acute radiation sickness after radiological or nuclear emergencies. For more about how we leverage existing technology & inventory management practices to ensure preparedness:
🆕 As a part of Project NextGen, we opened a new area of interest (AOI 15) under our Broad Agency Announcement (BAA), seeking submissions for the clinical development & efficacy of phase 2-ready next generation
#COVID19
vaccines.
We’re partnering w/
@JPEOCBRND
to provide subject matter expertise to
@humanigen
to support development of a monoclonal antibody therapeutic w/ potential to treat cytokine storm, reducing hospital stays & preventing lung damage from
#COVID19
. Learn more:
We are expanding our partnership with
@sanofi
to accelerate the development and large-scale manufacturing of a recombinant
#COVID19
vaccine that leverages the company’s existing recombinant vaccine platform.
We are proud to partner with
@Regeneron
to develop a potential therapeutic needed to
#SaveLives
from
#COVID19
. BARDA is supporting the Phase 2/3 clinical trial for this product.
BARDA joined partner Jubilant HollisterStier for a ribbon-cutting ceremony at their high-speed, commercial fill-finish line facility in Spokane, Washington. This project aims to enable faster domestic production of vaccines during a public health emergency
Congratulations to the entire
@Pfizer
team on the 1st COVID-19 vaccine in the US granted with
@US_FDA
emergency use authorization. This EUA allows the BioNTech vaccine purchased by the US government to be shipped across America to those who need it most to
#SaveLives
BARDA is delighted to announce that Gary Disbrow, has accepted the role of permanent BARDA director. Dr. Disbrow has served in many roles since 2007. Please join us in congratulating him as we continue to pursue our mission of addressing 21st century
#HealthSecurity
threats.
.
@Vaxart
announced the initiation of the sentinel cohort of its Phase 2b clinical trial, which we support under
#ProjectNextGen
. The trial will determine the efficacy, safety, & immunogenicity of their oral vaccine candidate. For more on our
#COVID19
work:
We’re excited to announce a partnership with Global Health Investment Corporation. The joint endeavor, BARDA Ventures, will use venture capital practices to accelerate innovative technology development to
#SaveLives
& mitigate public health emergencies.
For
#NationalVaccinationDay
, we’re recognizing our
#CBRN
Vaccine Branch’s investments to address multiple public health threats, as well as the importance of flexible vaccination strategies to protect all populations. To learn more, visit:
We're working w/ partners to develop alternative methods of vaccine administration like pills & nasal sprays. These vaccines can stimulate localized immune responses at the site of infection, elicit more diverse antibody responses, & avoid needles:
#NIAM
An important
#ProjectNextGen
focus is advancing next generation therapeutics to treat individuals with
#COVID19
& enable protection against the virus.
#NPM2023
BARDA is continuing to invest in next-generation products to protect Americans from
#COVID19
. So far, we have invested more than $1.5 billion in 29 products to help our nation beat COVID-19.
A key goal of
#ProjectNextGen
is to invest in
#COVID19
vaccine and therapeutic candidates that have favorable attributes that potentially increase access to prevention and treatment by better meeting the needs of America’s diverse population.
We’ve released a Request for Information (RFI) seeking information from current and potential biopharmaceutical partners regarding the advanced development landscape of next-generation
#COVID19
#vaccines
. Submit by April 25, 2023. Learn more:
Today, the seventh BARDA-supported
#COVID19
diagnostic test was issued Emergency Use Authorization by
@US_FDA
. This easy-to-use test was developed by
@QIAGEN
to be added to the currently approved the QIAstat-Dx Respiratory Panel.
BARDA is supporting a portfolio of
#COVID19
diagnostics to enable early detection & help
#SaveLives
. This week,
@US_FDA
approved a BARDA-supported rapid, hand-held, point-of-care diagnostic test for SARS-CoV-2 that was developed by
@mesa_biotech
.
📣 Our BID Day 2 Breakout Sessions will cover BARDA’s efforts in supporting the innovation & advancement of
#medicalcountermeasure
development & national preparedness. There will also be opportunities to meet w/ stakeholders about funding & possible partnerships.
⏳ As a part of Project NextGen, we’re still seeking submissions for the clinical development of next generation
#COVID19
vaccines. The Broad Agency Announcement is open for submissions. Learn more:
We are proud to partner with
@OraSure
to develop a rapid point-of-care
#COVID19
diagnostic for use in clinical & hospital labs or for self-test. The test could be run on both symptomatic and asymptomatic patients and provide results in just 20 minutes.
We are proud to partner with
@JPEOCBRND
& SAb Biotherapeutics, Inc. to develop a therapeutic treatment for
#COVID19
. This therapeutic uses tech that has the potential to be safer, more effective, & longer lasting than current polyclonal antibody therapies.
Project NextGen will accelerate and streamline research and development of vaccines and therapeutics against
#COVID19
. BARDA &
@NIAIDNews
are collaborating on this effort to spur innovation through public-private partnerships.
🆕 The BARDA Broad Agency Announcement now includes seven areas of interest related to
#COVID19
medical countermeasures, including vaccines, therapeutics, diagnostics and more. Find out about new opportunities for partnership ➡️
#HealthSecurity
BARDA is supporting US government market research to identify medical countermeasures with the potential to help address the
#2019nCoV
outbreak. If your company is developing diagnostics, therapeutics, vaccines, or other products, submit your ideas here ➡️
@T2Bio
@US_FDA
With the T2Biothreat Panel, clinicians can identify multiple bacterial organisms in a single sample within 4 hours, enabling patient care decisions 1-3 days faster than the current standard. This approach allows earlier treatment and can improve patient health outcomes.
Welcome to Sandeep Patel, PhD (
@innovationwonk
), DRIVe’s new director – here to make a difference and help
#SaveLives
with innovative approaches across the spectrum of systemic challenges to ensure our nation’s health security.
When BARDA Director Rick Bright got a minor cut while gardening, he wasn’t expecting it to get infected with MRSA. Find out how that cut & a delayed diagnosis led to the misuse of antibiotics, threatened patient health, increased healthcare costs & more.
⏳ As a part of Project NextGen, we’re still seeking submissions for the clinical development of next generation
#COVID19
vaccines. The Broad Agency Announcement is open for submissions. Learn more:
Save the date: BARDA Industry Day 2020 Tuesday Oct 27! Spend the day with us during our first fully digital conference and learn how we are Responding Together, Preparing for Tomorrow.
#BARDA2020
Hear from Dr. Robert Johnson, Director of BARDA’s Medical Countermeasures Program, about the effort between BARDA &
@NIAIDNews
to support development of new vaccines & therapeutics to better address
#COVID19
& family of viruses through
#ProjectNextGen
:
Through
#ProjectNextGen
, BARDA, in collaboration with National Institute of Allergy and Infectious Diseases (NIAID), will leverage public-private partnerships to develop new vaccines and therapeutics to enhance our preparedness for future
#COVID19
strains & variants.
Recently published: BARDA is supporting Phase 2b clinical trials of next-generation
#COVID19
vaccines with potential to improve efficacy & safety through
#ProjectNextGen
. Learn about the goals of these BARDA-supported clinical trials & access the article:
Antibiotic resistance is a huge concern of BARDA’s. And it's one we must work together and take an end-to-end approach to solve. No one group has the solution, just as no single antibiotic is a silver bullet.
#HealthSecurity
#AMR
#WorldAMRCongress
@CARB_X
@CMSGov
Registration now open! We will host a virtual workshop:
#ProjectNextGen
: Enablers for Innovative COVID-19 Vaccine Manufacturing on July 20, 2023, at 1:00 p.m. ET. Learn more and register:
Under
#ProjectNextGen
, we’re partnering with multiple companies to support acceleration of Phase IIb clinical trial initiation for next generation
#COVID19
booster vaccine candidates and support data collection and statistical analysis:
Are you developing a new
#COVID19
vaccine or treatment? Request a TechWatch meeting to learn about Project NextGen, a new initiative to accelerate next generation COVID-19 medical countermeasures and to tell our subject matter experts about your product:
Today,
@US_FDA
approved the first antiviral drug to treat individuals symptomatic with smallpox disease. This drug is major milestone for biosecurity and the 38th FDA approval of a BARDA-supported product.
One of the program areas for Project NextGen is Strengthen: to advance next generation COVID-19 vaccine candidates, including broader, more durable protection, and better transmission blocking capabilities.
Masks have played a critical role in combatting COVID-19. The BARDA,
@NIOSH
&
@NIST
#MaskInnovationChallenge
is accelerating the development of the next generation of masks to protect the public from a variety of airborne threats. Read more:
Today, the ninth
@BARDA
-supported SARS-CoV-2 diagnostic test received
@US_FDA
’s Emergency Use Authorization, helping to further expand
#COVID19
testing capacity.
@Hologic
’s Aptima SARS-CoV-2 assay can provide initial results in just 3 hours.
#MakingCountermeasures
Day 26: A
@ChembioDx
technician runs the DPP®
#COVID19
Antigen Test, being developed for the Chembio DPP® Micro Reader II with actionable results in 15-20 minutes
BARDA and
@US_FDA
will host a virtual workshop titled Recombinant Protein-Based COVID-19 Vaccines on April 27, 2023, from 9:00 am EDT to 1:00 pm EDT. To register, visit:
Congratulations to our long-standing partner,
@JanssenUS
, on their
#COVID19
vaccine EUA. Janssen was the first of seven
#COVID19
vaccine programs supported by BARDA.
We are proud to partner with
@MayoClinic
in concert with
@US_FDA
guidance to fight
#COVID19
. More than 48,500 patients have been transfused with convalescent plasma as part of this BARDA-supported program.
We’re partnering w/
@JPEOCBRND
,
@Sanofi
, &
@GSK
under
#WarpSpeed
to develop & produce an investigational adjuvanted
#COVID19
vaccine, including a demo of large-scale vaccine manufacturing w/ an adjuvant to enhance vaccine effectiveness.
We're seeking innovative proof-of-concept technologies enabling on-demand manufacturing of next generation
#COVID19
vaccine candidates using mRNA, recombinant protein, virus-like particle or viral vector platforms at the point-of-service. Submit by 9/1/23:
⏳ As a part of Project NextGen, we’re still seeking submissions for the clinical development of next generation
#COVID19
vaccines. The Broad Agency Announcement is open for submissions. Learn more:
To ensure communities are protected against infectious diseases, we’re partnering to advance vaccine delivery methods, enhance vaccine storage capability, support vaccine research & development for safe, effective, accessible vaccines.
Learn more:
Interested in submitting to our open AOI 15 for the clinical development & efficacy of phase 2 trial ready next generation
#COVID19
vaccines under Project NextGen? Attend our live Q&A session on May 17. Submit questions & register at:
We are proud to announce the latest addition to our growing portfolio of
#COVID19
medical countermeasure development projects! BARDA will partner with
@JanssenUS
on the development of a new therapeutic product to treat patients with
#COVID19
.
Today marks the start of World Antimicrobial Awareness Week 2020
#WAAW
. Each year, more than 2.8 million Americans develop drug-resistant infections and more than 35,000 die from them. Learn what BARDA is doing to combat
#AntibioticResistance
#AntibioticResistance
is one of the most urgent global threats to the public’s health. Any time
#antibiotics
are used, they can cause side effects and contribute to the development of antibiotic resistance.
#WAAW
BARDA and
@Crossject_
are working together to advance
#HealthSecurity
&
#preparedness
against nerve agent attacks. Under Project BioShield, we are developing a more efficacious & needle-free autoinjector seizure treatment for both children & adults:
One goal of our 2022-2026 Strategic Plan is to maintain a mission-ready response posture. To support this, BARDA is increasing U.S. manufacturing capabilities to produce
#medicalcountermeasures
at the scale needed for future
#publichealth
emergencies:
We are partnering with
@Luminex
to develop an easy to administer molecular diagnostic test for
#COVID19
. The test can be performed in community hospitals and other facilities with access to medium-complexity labs.
We are excited that long-standing partner
@Regeneron
has received
@US_FDA
approval of the first safe, effective treatment for
#Ebola
. Inmazeb® is an anti-viral antibody ‘cocktail’ for the treatment of infection caused by Zaire ebolavirus in adult and pediatric patients.
For this AOI, next generation vaccines include those with enhanced breadth of protection against variants, improved durability, and those with an enhanced ability to block infection/transmission including mucosal vaccines, relative to currently approved vaccines.
There's still time to respond! We’ve released a Request for Information (RFI) seeking information from current & potential biopharmaceutical partners regarding the advanced development landscape of next-generation
#COVID19
vaccines. Submit by May 26, 2023:
Through
#ProjectNextGen
, BARDA and
@NIAIDNews
are leveraging
#PublicPrivatePartnerships
to advance the development of MCMs, including vaccines & therapeutics, to better protect people in communities nationwide from current & future variants of SARS-CoV-2:
🆕
#ProjectNextGen
opportunity under the
@RRPV_Consortium
. Interested in supporting the development of manufacturing technologies that can produce on demand vaccines & therapeutics against
#COVID19
& other
#HealthSecurity
threats? Submit abstracts by 9/25:
Welcome
@Hologic
, our first
#COVID19
diagnostics partner! The assay is being developed to detect SARS-CoV-2 on the Panther Fusion system & could be considered for Emergency Use Authorization by
@US_FDA
soon.
Coming soon! To address the growing threat of
#AntibioticResistance
, BARDA will be hosting a virtual workshop in early 2021 to better understand the AMR vaccine landscape of 4 targeted pathogens: E. coli (urinary), K. pneumonia, P. aeruginosa, & S. aureus.
#WAAW
This
#NationalPreparednessMonth
, we’re recognizing the steps BARDA has taken to
#BeReady
to mitigate the impact of potential pandemic influenza viruses. W/ our partners, we work to provide timely, continuous updates of stockpiled vaccines...
We are excited to welcome our new German partners into the
@CARB_X
Accelerator Network! Together, we will support the early development of antibiotics, vaccines & diagnostics to combat drug-resistant bacteria.
Our partner
@CARB_X
is seeking vaccines, antibiotics, rapid diagnostics & other medical countermeasures to detect, prevent, or treat antimicrobial resistant bacterial infections. The deadline to submit is Jan 30, 2023 @ 23:59 ET:
Just Launched: Pediatric COVID-19 Data Challenge with
@NCATS_NIH_gov
,
@HRSAgov
,
@NICHD_NIH
. Help clinicians predict which among their pediatric patients will develop severe COVID-19 complications, including conditions like MIS-C. Read more:
The
@US_FDA
has issued EUA for
@Moderna_tx
’s mRNA
#COVID19
vaccine. Co-developed w/scientists at
@NIAIDnews
, BARDA, & Moderna, this innovative partnership has developed a safe & effective COVID-19 vaccine within a year. Read more:
Today at the
#BLUEKNIGHT
Symposium, BARDA and
@JNJInnovation
(
@JLABS
) announced the BLUE KNIGHT QuickFire Challenge: Accelerating Project NextGen. Applications due June 30, 2023. Learn more about the challenge and apply:
Take a behind-the-scenes look at medical countermeasure research, development & manufacturing programs that BARDA’s partners have undertaken to fight the
#COVID19
pandemic! Join us as we embark on the
#MakingCountermeasures
series! Check back daily for updates.
Under
#ProjectNextGen
, BARDA seeks information on the potential use of “pull incentives” to drive
#COVID19
vaccine development and commercialization, including in partnership with other sponsoring organizations. Respond to our RFI by 8/10:
BARDA is partnering with
@Luminex
to develop a rapid high-throughput
#COVID19
diagnostic test to enhance capacity in hospitals across the country. Luminex Corp received
@US_FDA
Emergency Use Authorization on March 27.
BARDA continues our partnership with Cue Health to develop a portable diagnostic point-of care device connected to a mobile health platform to detect SARS CoV-2 to be considered for Emergency Use Authorization by
@FDA
.
📣 Our BID Day 2 Breakout Sessions will cover BARDA’s efforts in supporting the innovation and advancement of
#medicalcountermeasure
development and national preparedness. There will also be opportunities to connect with stakeholders about funding and possible partnerships.
A comprehensive study by BARDA,
@CMSgov
& Acumen LLC finds that sepsis is more common and costly than previously understood. Find out how the burden of
#sepsis
threatens everyday health,
#HealthSecurity
, and our economy.
#SolvingSepsisTogether
We are proud to partner with
@nanomixinc
to develop a rapid and accurate
#COVID19
diagnostic for use in near-patient settings – with results in just 15 minutes
According to
@WHO
, antimicrobial resistance is one of the top 10 global public health threats. In this edition of the
@ASPRgov
Blog, BARDA’s Mark Albrecht & Christy Ventura explain how we are partnering with industry to develop new solutions to fight
#AMR
.
BARDA seeks a senior level biologist to serve as a project manager of a portfolio that includes medical countermeasures to address CBRN threats, influenza, and/or emerging infectious diseases, such as
#COVID19
. Contract management experience desired.
A new Stewardship & Access Plan Development Guide, developed by
@wellcometrust
in partnership with
@CARB_X
, can help product developers strategize to facilitate faster & broader access to innovative antibacterials while fostering
#antibiotic
stewardship.