Adam Kolom
@AdamKSay
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Biotech entrepreneur and investor. Cofounder and CEO, Related Sciences. Cofounder, Parker Institute for Cancer Immunotherapy.
Los Angeles, CA
Joined July 2011
for most diseases, the best medicines are soon to come. why? better disease targets x 10 new/better modalities x better discovery x better clinical precision = golden decade for new drug creation, addressing 2 big opportunities: 1. treat the ~75% of 13,000+ disease segments w no approved medicines 2. replace last generation medicines w more effective and safer meds
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quick human tech appreciation post, oppositional to hedonic adaptation
I still cannot believe that I can: - look at a world map and tap anywhere to zoom in at street level - instantly access any song, book, movie, tv show, or podcast ever made - have any conceivable question and get an immediate answer or video explanation - take a photo or video wherever I am and add it to my massive, searchable, always accessible personal archive - video call anyone in my life, at anytime, no matter where they are - watch live sports on a little wireless glass rectangle - type out these thoughts and have them read by thousands of people, all over the world, a few seconds later
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RT @bradloncar: FT and WSJ both with articles in the last 24 hours on the China bio topic. As news of this goes mainstream, cue the politic…
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@nikitabier insightful. everyone wants that stochastic beta, but not that hard earned alpha. and if they win they feel like geniuses, but if they lose was clearly an anomaly. idiot dopamine addiction pandemic
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RT @Kasparov63: The constant conflict is the point. To be a big boss, you have to have enemies. You have to tell your followers that only y…
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Ah yes, uniting all our biggest trade partners against us while driving up the cost of all domestic goods dramatically. such a 4d chess move, national self immolation is
Aside from the general issues about Trump‘s tariff and his economic nationalism strategy, today’s actions against Canada and Mexico are inexplicable and dangerous. 1/8
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Fascinating moment. All of the frontier models will implement the 5-10 efficiency advances deep seek introduced and price of inference will plummet. This is net good for AI to revolutionize productivity faster and drive up demand… which will drive chip sales and energy needs. Demand for intelligence is price elastic like most other things.
DeepSeek's new R1 reasoning model is dragging down the NASDAQ. It dropped 6 days ago but it seems Wall Street is only now digesting what it means. I'm no equity analyst, but a few things I've been thinking about. DeepSeek is a huge deflationary shock to the price of intelligence. R1 is outcompeting OpenAI's O1 model for likely less than 1/20th the cost, and they are doing it with only 32B active parameters (GPT-4 likely used ~220B active parameters according to @SemiAnalysis_). They also fully open sourced all of their models, the distillations, and a comprehensive paper detailing how they did it. Intelligence is now way cheaper than we thought. This is great for all consumers of AI—meaning you and me. So why is the NASDAQ tanking? Remember, the NASDAQ is an index of producers, not consumers. The price of oil plummeting is bad news for oil companies, but it's great for those of us who drive. The fact that NVIDIA and all of the hyperscalers are so overrepresented in the NASDAQ these days means the stock market is structurally long the price of intelligence. So who benefits from this deflationary shock? I think there is one company in particular that is best positioned now. It's now been more than 2 years since the release of ChatGPT, and it's clear that no lab has that much of an edge. It only takes a few months for Google, OpenAI, Anthropic, and now DeepSeek to copy each other and trade spots on the leaderboard. This is partly because these companies all publish research (researchers want glory) and even for stuff that's unpublished, these organizations leak like sieves. Engineers want to know how things work. It's quite literally the most interesting question in the world: what is intelligence made of? Labs are just not able to hide this without military grade secrecy (and none of the best talent wants to work for the military). So we're stuck in this status quo. Everyone is trading places at the top of the leaderboard, nobody has a clear long-term edge, and DeepSeek and Meta are intent on open sourcing their models, which causes closed models to continually depreciate. Even with all this AI spend, there don't seem to be any durable moats. So who does have a structural moat here? Look at OpenAI. Sora is already behind the state of the art on video (Kling and Veo are racing ahead). Dall-E is OK but no longer best in class. They are now betting hard on Operator, which is their agentic model. Operator is supposed to be able to book flights, order food, do agentic stuff for you. But it has significant problems aside from the coherence of the model itself: If you are working directly with one of their partners like Instacart, Operator gets full access. But much of the open web appears to be blocking Operator, and that may get exacerbated if the web is crawling with Operator instances. You also have to keep handing control back and forth to log in and out of services, solve Captchas—it's all quite cumbersome and finnicky. Take Google on the other hand. Gemini is quietly #1 on @lmarena_ai. They are #1 on image generation with Imagen. They are ahead on video with Veo. They aren't doing anything agentic yet—Google is usually the last mover on the sexier stuff—but once they do, they have a huge structural advantage. Google's webcrawler bots already have full license to touch everything on the web. They already have access to your Gmail, calendar, they can easily traverse the web and have cached most of it (DeepResearch shows how easy this is for Google), and they also have the crown jewel of untapped data: Youtube. And, of course, they are uniquely positioned to drive agents directly on Androids. Although Google is spending a ton on compute, and they are still a hyperscaler, Google is net short intelligence. They are a consumer of AI in order to serve their customers. DeepSeek and this intelligence deflation is long term good for Google, as it means their own spend will go down. It's cool to hate on Google these days, but I think Google ends up being the long-term winner here if DeepSeek-R1 spells a secular trend. That said, don't count out OpenAI. They are still the strongest product company, and they've earned trust from consumers and enterprises for always being 3 months ahead of the rest of the market. They basically invented the entire test-time compute paradigm, and o3 is a real breakthrough which has yet to drop. If intelligence is the most valuable resource in the world, being 3 months ahead of the competition is enough to earn themselves a big premium, and huge enduring trust from their customers. So yes, the biggest loser here is NVIDIA. If China is a real player (and NVIDIA is not allowed to export to China), and DeepSeek is massively deflating the price of intelligence, and they were able to do all of this on nerfed H800 chips, then NVIDIA is in trouble. You want to be in the game of selling intelligence. NVIDIA is in the game of selling FLOPs. If the ratio of FLOPs to intelligence goes down, down goes NVIDIA stock. So it goes. And of course, we have to say it: congrats to @deepseek_ai team in wiping out a trillion dollars of equity value from the NASDAQ. That's six OpenAIs in a single day, vaporized. Not bad. 👍
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RT @fperrywilson: Every week, I see a new study talking about this or that effect of GLP-1 receptor agonists like #ozempic. FINALLY, we hav…
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@fperrywilson amazing breakdown, and incredible discovery data truly game changing for global society, especially once they are lower cost and broadly accessible the [cure] to the modern metabolic mess!
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AI for education
New randomized, controlled trial of students using GPT-4 as a tutor in Nigeria. 6 weeks of after-school AI tutoring = 2 years of typical learning gains, outperforming 80% of other educational interventions. And it helped all students, especially girls who were initially behind
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Amen.
No. I am purple pilled. There are tens of millions of people born unlucky, lost ovarian lottery, system stacked against them––and they need + morally deserve help. It would be great if private donors + scholarships + foundations could do it all but they can’t and don’t. I came from nothing. Single mom, school teacher, union member, we lived with her parents (retired meter maid parking meter attendant grandma + night shift NY Daily News delivery truck driver grandpa). Public school + then later scholarships helped but so did healthcare + union support for my mom and me I also believe in the full expression of free enterprise, entrepreneurship, risk taking, rewarding those who solve problems and get rich (or lose it all) and the free flow of capital to solve ‘what sucks’ in pursuit of self-interest. In greed and avarice lies the hope of progress as my old friend Jim Surowiecki said and progress reduces human suffering. Powerful people should pull up others not punch down. Nor mistake their own measures of good luck for pure skill. I abhor the far left and far right who per horsehoe theory (well known but well articulated in a great video i reposted recently by @DanielLubetzky) are fueled on unproductive zero-sum hate not positive-sum high expectation compassion Not everyone in a victim class is a victim. Not everyone in the 1% is deserving. Life is unfair in distributions of health and wealth and looks and ability. Zip code your born or raised in determines your future health and wealth more than most other variables. Social + economic upward mobility is far less than it ought be, but also far more than people see. I’m living proof. No rich family, no inheritance, broken home, parents that despised eachother and i ended up a pawn. I was lucky to have a doting mother who sacrificed her life in many ways for mine (and i didnt appreciate it enough until i had my own kids—exactly as she had told me;) I’m happy with a TON of people in new Trump admin. They will do amazing things for our country. I wouldnt want my kids to ever be like him or look up to him. I also deeply respect a TON of people in the Biden admin, and unwaveringly love our military and veterans who have sacrificed and lost more than 90% of the country will ever know or experience. So color me PURPLE
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