Arthur Charles-Orszag
@A_CharlesOrszag
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Postdoc @UCSF @MullinsLab | Big fan of LUCA | @ArchaeaPowerHr @ArchaeaBio | Institut Pasteur, LSRF alumn | he/him 🇫🇷 🏳️🌈
San Francisco, CA
Joined February 2020
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Pinned Tweet
I am beyond thrilled to share that I will be joining the department of Microbiology and Molecular Genetics at
@ucdavis
as an Assistant Professor in March 2025. Go archaea!!
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Archaea can twitch too! In our new preprint we show that, despite the absence of a retraction ATPase, S. acidocaldarius cells undergo twitching motility. Awesome collaboration between
@MullinsLab
@Archaellum
@marleenvw
and
@samjlord
.
🧵 1/4
Sulfolobus acidocaldarius adhesion pili power twitching motility in the absence of a dedicated retraction ATPase
#biorxiv_cellbio
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@Archaeon_Alex
I also want to share here that I made a shrine to Dan Gibson in the lab and I make offerings when starting new cloning projects
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Thank you Dyche
@MullinsLab
for my new hi-res gel filtration column. I kinda feel like Harry Potter when he gets the Nimbus 2000 ⚡️
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Not one but 3 papers on the structure/function of Sulfolobus Aap pili published as a back-to-back… to-back! Out today in
@NatureCommunications
. Brought to you by
@DaumLaboratory
@jerrynosnothing
Edward Egelman
@mkrupovic
@Archaellum
@MullinsLab
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Our high temperature microscope paper is now published in
@FrontMicrobiol
! 🥳
Sulfolobus has never been this hot, thanks to
@MullinsLab
@samjlord
.
I’m also grateful for a great peer review process that has made this story even better, check it out!🔥
High-Temperature Live-Cell Imaging of Cytokinesis, Cell Motility, and Cell-Cell Interactions in the Thermoacidophilic Crenarchaeon Sulfolobus acidocaldarius
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The concept of one-actin/one-function (Bact) vs one actin/multiple-functions (Euks) is not new, but archaeal actins really makes you want to speculate that multifunctionality predominantly emerged in archaea. Read our latest review with
@MullinsLab
and Natalie Petek-Seoane!
Mapping the structure & function of actin-like proteins in archaea provides insights into the evolutionary relationship between filaments found in bacteria & actin cytoskeletons that characterize eukaryotic cells. Learn more in this
#JBacteriology
review:
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I too am giving tho
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So I shared some thoughts with
@ASCBiology
about considering a career in academia when you’re LGBTQ+. Thanks for reading!
Thank you Claire Thomas and
@kskruber1
for giving me the opportunity to speak up for our community!
#LGBTQ
#STEM
Will I be safe applying for a job at your school? New blog post from Arthur Charles-Orszag
@A_CharlesOrszag
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In the
@MullinsLab
I also made a shrine to Arthur Kornberg (first to isolate DNA polymerase I in 1956).
We make an offering when starting a new protein purification project ✨🤞🏻
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🚨 Hey
#CellBio2022
if you want to learn how hot archaea use pili to crawl across surfaces, come see my microsymposium!
@MullinsLab
@Archaellum
collab ♥️
⏰ Tuesday 11.15 am, session Spatial Regulation of the Cell
⏰ Tuesday 12.30 pm poster B709
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No tears, no goodbyes! Way to end the
@MBLPhys
course. The dream team:
@MullinsLab
@samjlord
@kskruber1
@IsabellaGaeta1
@ia_windham
@JoeCiriloPSU
@cthrntan
. Thank you
@MBLScience
!
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All set up! A mini
@MullinsLab
ready to solve hot archaealogy mysteries at the
@MBLPhys
@MBLScience
🔥 🔥 🔥
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⚡️ So grateful to have had the opportunity to give a lightning talk yesterday at
#cellbio2021
⚡️ Come chat about chromosome segregation in Sulfolobus at our poster number P1047
⚡️ Thursday Dec 9 - 7 PM EST (4 PM PST)
⚡️ Friday Dec 10 - 9.15 AM EST (6.15 AM PST 🥵)
@MullinsLab
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Today is my four-year anniversary as a postdoc in the
@MullinsLab
! 👵🏻
Despite two years of Covid, how fun has this been! Here’s to more fun and great science.
Shout-out to my awesome team mates and especially my favorite co-author/scope buddy extraordinaire
@samjlord
♥️
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I can’t explain it but that’s what I imagine my proteins look like when I use sucrose in my buffers.
And that’s OK.
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Omg would y’all look at how cute and fluffy my contaminant is 🥺
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I can’t have Dyche, but can I steal
@samjlord
Huge congratulations to Dr.
@A_CharlesOrszag
who has just gotten a tenure-track position at UC Davis! Expect great things from the Charles-Orszag Lab!
Here is Arthur performing the ceremonial signing of the champagne cork divot in the ceiling of the lunch room!
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I advocate for a mandatory nap every day
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Also, thrilled to lead a session at the 2025 Bacterial and Archaeal Cell Biology and Development
@GordonConf
!
Archaeologists unite!
Announcing the 2025 Bacterial and Archaeal Cell Biology and Development
@GordonConf
. We have amazing speakers and discussion leaders confirmed and look forward to (again) having our minds blown by all the remarkable science. Applications will start being accepted in the fall.
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The dawn of a new era in archaeal cell biology! Nicely done
@Alejandra_ReCa
@Archaellum
@marleenvw
et al 😎, can’t wait to try it
The use of thermostable fluorescent proteins for live imaging in Sulfolobus acidocaldarius
#biorxiv_micrbio
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Go Sulfo!
@Archaellum
@marleenvw
@APH_AME
@APH_Europa
brought together
@MBLScience
thanks to the Microbial Diversity course ♥️
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.
@MullinsLab
retreat was literally 🔥 with
@LauraCheradame1
@samjlord
et al. and special guests
@SheuJess
@ScienceyRosalie
@dsboothacosta
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Probably the most unsettling image I’ve helped taking 🥴
Peak-a-boo👀Toxo parasites make a hole in your cells when they're done growing and ready to leave. Here's an SEM image of two parasites destroying their host on their way out to find a new cell to invade. Obtained with the generous help of
@A_CharlesOrszag
+
@samjlord
@MBLScience
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Our amazing
@MBLPhys
Sulfo crew driving the SEM
@MBLScience
.
@cthrntan
@ia_windham
@samjlord
are quite the dream team ✨
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Seen at the Washington convention center.
@Choano_Lab
@dsboothacosta
did one of you guys did that?
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Sampling sea stuff just like when I a kid and wanted to be a scientist 🥲
#careergoals
@MBLScience
@MBLPhys
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A new affinity purification tag but gender neutral, like 6xTHEIR
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TFW when you purify a protein and there’s so much of it that it shows on the gel even before destaining 🤤
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Sulfolobus like to dance 💃🏻. And sometimes they take a break and kiss 😗 (DIC, 100X, 75C).
@MullinsLab
.
@samjlord
.
#Archaea
#Microscopy
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Bacteriologist and two archaea scientists at a micro conference
Basic science researcher in a department that mostly does translational research
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🚨 New paper from
@lab_baum
out now! Congrats to
@aleececezanne
and all the authors on a tremendously useful work. This is exactly what the archaeal cell bio community needs
New Research: Probing archaeal cell biology: exploring the use of dyes in the imaging of Sulfolobus cells
#microbiology
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Drink sizes at Starbucks should be mini, midi and maxi
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🚨 Dyche (
@MullinsLab
) and I are excited to host a Special Interest Subgroup on ‘Cell Biology at the Extremes’ at
#CellBio2024
@ASCBiology
@EMBO
!
🌈 Archaea, Bacteria, Euks and Viruses are all welcome
⏰ Submit your abstract by August 6 to be considered for a talk!
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We didn’t have a coverslip holder to run our samples in the manual critical point dryer so… 📏🔥🔪
@S_Shamphavi
@Alejandra_ReCa
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I love playing field scientist
In addition to super-resolution light microscopy, high-temperature live-cell imaging, microfluidics, biochemistry, and scanning electron microscopy, we also took time out for some collecting trips around the bay, led by Jose de la Torre from SF State.
@UCSF
@A_CharlesOrszag
(5/n)
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Tryna keep the
@MullinsLab
cute
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Ahhh! My favorite monthly conference starts next week! 😍Calling all archaea fans to join us
Archaea enthusiasts, are you ready for the first Archaea Power Hour series of the semester? Because we are excited to announce our star-studded lineup! Join us Tuesday, September 14 at 11 AM! The Zoom link will be sent via our listserv. (1/2)
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We all like a good hug 🤗.
Sulfolobus surely knows how to squeeze in! (DIC, 100X, 75C)
@MullinsLab
.
@samjlord
.
#Archaea
#Microscopy
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Can’t guarantee everything I said is accurate, BUT happy to put archaea in the limelight as they clearly are the best microorganisms ever ♥️ Thank you Julia!
This week’s
#TinyLivingBeings
episode is all about
#archaea
! I have a fun conversation with
@A_CharlesOrszag
about his research on Sulfolobus acidicaldarius and lots of other archaea things. Found everywhere you get podcasts!
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It’s technically right but it feels wrong 🥴 Tubes should face lines right?? Please tell me I’m not the only one
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@samjlord
3D printed a box for me to use as a benchtop coverslip incubation chamber 😍
@MullinsLab
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Weka detector making Sulfolobus cells look like tiny color-challenged-NON-friendly Poké Balls
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.
@lancetdenes
and
@gil_h_
killing it
@MBLPhys
🔥
Also thank you
@interherence
for the amazing VAHeats!
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We combined live cell imaging at high temperature and automated cell tracking with TrackMate 7 to show that twitching motility is mediated specifically by Aap pili, suggesting that these pili are dynamic
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TFW a colleague accepts my invitation to review a manuscript
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Excited to guest edit this Research Topic with the dream team! ✨
We (
@A_CharlesOrszag
,
@S_Ithurbide
,
@Catherine_Badel
,
@GeoSantiagoM
and I) are happy to announce a Research Topic in
@FrontMicrobiol
linked to the Molecular Biology of Archaea meeting in Frankfurt, we are looking forward to your submissions!
#EMBOarchaea
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Where we keep negative and unexplained results
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Excited to be part of the
@ArchaeaBio
project!
What a great time to be an archaea-ologist (should we make this neologism happen please vote 🤔)
📢 Ready to meet our first speaker? Sulfolobus lover
@marleenvw
will introduce us to the
@ArchaeaBio
initiative! Don't miss it!
#Archaea
#APHeuropa
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A quiet place 🥺
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So excited to co-host the next Archaea Power Hour conference with
@microbe_mack
! Way to start our 2022 series!
Tuesday Feb 15, 1 PM EST
Fellow Archaea enthusiasts, we are happy to announce our first seminar series of the semester! Join us next Tuesday February 15 at 1:00 PM EST. Here is our exciting lineup of speakers. You don't want to miss it! Looking forward to seeing you all there!
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⏯ Coworker texts me this during zoom meeting and says “caught your nose”
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Spread the word! I can’t stress enough how presenting your work at the Archaea Power Hour is a great opportunity to connect with the community. Undergrads and grad students, don’t be shy 👀
@archaea_power
Archaea enthusiasts! We are now accepting micro abstracts for presentations this Fall and Spring semesters. We HIGHLY encourage undergraduate participation from summer internships. Fill out the qualtrics survey below if interested. Deadline is August 31!
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We all look rundown but FIERCE
Thanks to the talented and hard-working students and TAs for making this year’s Physiology Course a smashing success! Laura, Sam, Arthur, Dora, Gil, Ushnish, Lance, and Kristen (not shown)
@MBLPhys
@MBLScience
@LauraCheradame1
@A_CharlesOrszag
@samjlord
@kskruber1
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A truly transformative scientific and human experience, directed by two amazing people and hosted by an outstanding research institute, right here👇🏻👇🏻👇🏻
The
@MBLPhys
family can only grow bigger! Check it out!
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My only plan for Valentine’s Day 💕
Save the date!
We're back!!! Join our 1st meeting of the semester this coming WEDNESDAY, February 14th ❤️ at 10 AM EST / 4 PM Paris Time. We have two exciting talks planned for you! Check your email for the link or if you're new, sign up to be a part of the community at:
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Acanthamoeba courtesy of
@MullinsLab
and Nat Petek! All I did was the SEM ⚡️
we had the world premiere of the "Living Like An Amoebae" art project in the
#AML
.
The work was presented by
@amarantakahn
and
@tinadynamics
and includes work by
@Alexhangsong
@A_CharlesOrszag
@Nicxy14
@MBLScience
C Leclerc, R de Corbière and L Sady | photo by
@Michael130991
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@cthrntan
and
@ia_windham
turning off our incubator after our last Sulfo culture
@MBLPhys
with
@MullinsLab
👋🏼🥺
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Haloarchaea in concrete?? Guess some cells really do have a hard life
Double feature tweet, in case you still haven't heard, our final session (for this semester) of APH is TOMORROW at 1 PM EST. Our last speaker Anders Kiledal will be talking about halophiles in CONCRETE. Get your coffee and sourdough ready, you don't want to miss this one!
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Forget the little string thingy! We found a better solution
The pen for the logbook kept walking away, so we secured it. Now you just have to move the paper to write.
Sometimes the simple solutions are the best.
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Advancing the field of archaeal cell biology one (set) of tools at a time. Glad I got to be editor for this one!
Our Pxyl paper is out. Congrats to
@theopi
and Katie Andre (co-1st) and my invaluable co-last Micaela Cerletti. This was a fast paper, less than a year from concept to pub.
Thank you
@A_CharlesOrszag
(best editor) and our reviewers for correcting us.
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Save the date! Thursday Oct. 13! 🦠 (we need a better microbe emoji by the way, who do we ask for that? Like what is 🦠 even)
🚨INTRODUCING🚨: our APH October seminar speakers! In just one week, our first of three archaea research seminars will commence Thursday Oct. 13th 1:00 PM EST. We can't wait to see you there! A reminder...to get the meeting link, join our listserv at
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Follow-up: 3D printed coverslip holder for use in the critical point dryer made by
@MichaelSpaedt
😎
@S_Shamphavi
@Alejandra_ReCa
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Thank you
@APH_AME
! And thank you
@biorxivpreprint
I think it’s a great idea to post talks along with their preprint (when possible)
Good news!
@BioRxiv
has decided to preprint some of our talks indexed to a preprint! The first one is our very own
@A_CharlesOrszag
's. Go take a look at it here! Congrats Arthur!
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I’m excited!
Archaea friends, APH is back NEXT Thursday at 1 PM EST! We have a great lineup of promising talks from ammonia oxidizing archaea, to retinal implants and Asgard archaea viruses!
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We were able to directly visualize pilus dynamics at high temperature and showed that Aap pili do indeed retract and power twitching motility
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And this is all thanks to a team of amazing friends and mentors
@MullinsLab
@samjlord
@ScienceKyle
@NAltemose
@dsboothacosta
@BEuplotes
@ArchaeaLab
@Archaeon_Alex
@Archaellum
@DumenilLab
@BassereauTeam
et al.
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We show that twitching is not restricted to S. acidocaldarius, suggesting that pilus retraction without a dedicated ATPase is common in archaea, echoing what was seen before in C. crescentus and V. cholerae. Did LUCA, that did not have a retraction ATPase either, twitch too??
4/4
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Found a serological pipette with a birth defect 😬
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Always a pleasure to work with the
@Archaellum
team!
We had an amazing time having
@A_CharlesOrszag
at
@Archaellum
lab! Learning and talking about science and beyond…We wish you all the best for your new PI adventures!!
Now we’re ready to crash the EMBO Molecular Biology of Archaea meeting in Paris next week 🎊😎
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Introducing
#PeerReplication
. I hope people find this idea exciting!
We're seeking feedback on our white paper on
#PeerReplication
.
@A_CharlesOrszag
@kskruber1
@MullinsLab
@AndersReh
and I propose an alternative or augmentation to peer review, where key experiments are reproduced, adding robustness to published findings.
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Archaeal pili really are in the limelight this week!
Check out back-to-back papers from Charles-Orszag et al …, who show that Sulfolobus uses Aap pili for twitching motility and Liu et al, presenting the structures of two distinct Sulfolobus pili composed of the same pilin.
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What a lineup! Can’t wait to be Tuesday! I totally remember the Krebs cycle… 👀
We have one question for you... are you ready? Are you ready for the October edition of the Archaea Power Hour?! We're very excited to announce our speakers for this month's edition! Join us this Tuesday, October 12 at 1 PM EST! Zoom link will be sent over our listserv email.
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So glad to be part of this!! 😎
Welcome new Archaea Power Hour Organizing Committee members: Anthony Kohtz, Arthur Charles-Orszag, Geovanni Santiago, Mackenzie Lynes, Maria Ines Gimenez, Micaela Cerletti, Priyanka Chatterjee, Rylee Hackley, and Willm Martens-Habbena!
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Best part of meeting for the
@LSRFdtn
annual meeting is catching up with amazing friends
@BirdBrainTosh
@_joseph_swift
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Incredible! 😍
Asgard archaea reignited discussions about the tree of life 🦠 But do they have eukaryotic features? YES!! 🤩 Check out our new paper
@Nature
by
@F_Wollweber
and
@xujw_thu
, in an exciting collaboration with the Schleper lab
@Archaea_Vienna
.
🧵1/4
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.
@samjlord
and I don’t do just microscopy. We make jokes too.
Okay, so two Asgard archaea are walking through a benthic sediment when they notice a nearby bacterium.
One archaean says, "How cute! Can I have it?"
The other says, "You take it; you carry it"
(say it aloud; courtesy of Arthur and Sam)
@MBLPhys
@A_CharlesOrszag
@samjlord
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The
@MullinsLab
used to be so dark. Now it’s all 🌸 🌺 ♥️ 🐻
Randomly came across this order in the
@MullinsLab
Quartzy.
Is
@fleshball
still a hardcore romantic? FYI it’s still back ordered :/
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APH is coming back bigger and stronger! 🚨 First global APH virtual conference this Wednesday 🚨
APH is back this week! THIS WEDNESDAY at 10 am EST / 4 PM Paris Time is the first of 3 seminars planned for our Fall 2023 session. Check your email for the meeting link and join us on Wednesday to hear from our first two speakers! Visit for more!
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Don’t miss it!
APH is back this week! Introducing our wonderful lineup of speakers! Join us this Thursday, April 13 at 1 PM EST for some more fun archaea talk!
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It was so much TAing again with you all! Mullins lab rocks 🤘🏼
It was my first time TA for
@MBLPhys
and it was a blast!
@MullinsLab
@A_CharlesOrszag
@samjlord
@kskruber1
❤️ Special thoughts for
@RanaUshnish
that stayed up on the microscope until 4am to uncover the secrets of the mysterious nuclear actin 🤩
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Finally meeting people in person!
Three of our
@APH_AME
organizing committee meeting in person for the first time. Possible thanks to the amazing networking and connections made during this wonderful APH initiative. Hoping for many more wonderful connections like this!
@pohlschr
@chattergenius
@A_CharlesOrszag
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Great new high-temp microscopy technique using localized IR irradiation of gold nanoparticles ✨
This would be perfect to study the cell bio of heat shock response in prokaryotes!
Thermophilic bacteria 🦠 activated using laser heating of gold nanoparticles at 60°C 🔥(Geobacillus stearothermophilus) monitored using wavefront microscopy in
@NatureComms
@InstitutFresnel
@PatrickForterre
@I2BCParisSaclay
@INSIS_CNRS
@ERC_Research
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Unstoppable
T-minus-2
@MBLPhys
& Team Octo is in full-on data analysis mode!
@tzerhan29
@MullinsLab
@A_CharlesOrszag
@samjlord
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I’m not even there yet and I can feel it
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