Reiff Lab
@twi_tobi
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https://t.co/IZ9DsuLmzo
HHU/Düsseldorf/Germany
Joined January 2016
Together, our findings provide insights into the complex endocrine growth control mechanisms during mating-induced adaptations and might help untangling pleiotropic hormonal effects observed in gastrointestinal tumorigenesis.
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Finally, mathematical modelling corroborates increasing enterocyte numbers and Wnt/Wg-degradation to set a stable post-mating intestinal size.
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Rapport-based ISC tumours confirm paracrine stimulation through the Ecdysone-Crol-Wg axis on mitotic behaviour, whereas the autonomous anti-proliferative role of Crol in ISC is conserved in models of colorectal cancer.
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Rapport tracing reveals that Ecdysone-induced Crol controls mitogenic Wnt/Wg-ligand expression from epithelial enterocytes activating ISC mitosis. Paracrine Wg stimulation is counterbalanced by Crol-repression of string/CDC25 and CyclinB autonomously in ISC.
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For the precise investigation of non-autonomous factors on ISC behaviour, we establish Rapport, a spatiotemporally-controlled dual expression and tracing system for the analysis of paracrine genetic manipulation while tracing ISC behaviour.
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Mating increases production of the steroid hormone Ecdysone released by the Drosophila ovaries that stimulates intestinal stem cell (ISC) divisions. Here, we uncover the transcription factor crooked legs (crol) as an intraepithelial coordinator of Ecdysone-induced ISC mitosis.
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Abstract: Female reproduction comes at great expense to energy metabolism compensated by extensive organ adaptations including intestinal size. Upon mating, endocrine signals orchestrate a 30% net increase of absorptive epithelium.
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Finally out, Lisa´s main PhD project with a new dual expression ReDDM tracing called Rapport and modeling of pregnancy induced gut size adaptations with Bernat.
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We are hiring for exciting projects on Drosophila and cell line models of leukemia on HHU Campus: Please share!
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RT @interactivefly: Christensen, C. F., Laurichesse, Q., Loudhaief, R., Colombani, J., Andersen, D. S. (2024). #Drosophila activins adapt g…
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RT @sofiajaraujo: I was a @FlyJedi and I can asure you it is great! If you are a JUNIOR EUROPEAN DROSOPHILA INVESTIGATOR, don’t hesitate in…
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RT @DrosophilaRTC: Fly Fact Monday 🔬🔬🔬🔬🔬🔬🔬🔬 #drosophila #fruitfly #drosophilaresearch #research #genetics #mutation #genes #biomedical #bi…
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RT @Hemasphere_EHA: In this single-center study germline WES data from 353 ped pts showed a significant assoc btw LZTR1 germline variants &…
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RT @schumacherbj: Absolutely thrilled to receive the @hevolution_f Foundation Geoscience Research Opportunities grants to lay the foundatio…
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@Borkhardt_Lab @Hemasphere_EHA @UniklinikDUS @HHU_de involving the best team, humanized ReDDM flies and ERK sensor transgenics @twi_tobi @AmoyelLab
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RT @MabelLTaracena: 🦟 NEW PAPER ALERT! In our most recent work we zoomed in on the mosquito midgut epithelium, and…
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RT @nicobuchon: New mosquito paper from the lab, great work of @MabelLTaracena and @BrettaHixson demonstrating how infection and blood feed…
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RT @LBastian_MD: LZTR1 germline variants predispose to Hyperdiploid ALL - remarkable functional validation from @Borkhardt_Lab using a Dros…
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