Lappalainen Lab
@tuuliel_lab
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Functional human genomics @ KTH, SciLifeLab, NY Genome Center. Pro science here, more fun stuff fun at @tuuliel. Mastodon [email protected]
Stockholm / New York City
Joined May 2020
One month until the CSHL Biology of Genomes abstract deadline! My all-time fav meeting, and one of the few covering genomics broadly. We have a ✨🤩 lineup of speakers, but it's the abstract talks & posters that make the meeting - send us your best work!
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@joe_pickrell @jkpritch One could test that quite easily by e..g looking at h2 enrichment in relevant tissues / cell types as a function of p-value rank. Also:
@jkpritch @joe_pickrell It's just that I don't think very many people focus their functional studies based on p-value ranking among significant GWAS hits.
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@joe_pickrell @jkpritch It sounds like you're defining "functional follow-up studies" as "single-gene-focused molbio". I too have significant reservations. But IMO most understand this more broadly and might read 👇 as "~all GWAS-to-function research is a huge waste of money". That I disagree with 😉.
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@jkpritch @joe_pickrell And knowing the causal variant would allow interrogation of its function, e.g. impact on TF binding, which is important for understanding how GWAS loci are linked via regulatory networks, and characterizing cellular context-specificity. And ofc fundamental biology of V2F.
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@jkpritch @joe_pickrell It's just that I don't think very many people focus their functional studies based on p-value ranking among significant GWAS hits.
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🌟 Exciting news: The Leena Peltonen School of Human Genetics returns in 2025! We're excited to bring PhD students together with an all-star list of leaders in human genetics. 📅 July 27-31, 2025 📍 Wellcome Genome Campus, UK 📝 Apply by March 7 at
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RT @MariosGeorgakis: GTEx (@GTExPortal), the most comprehensive multi-tissue #transcriptomics resource out there, has now released a new da…
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RT @NatureBiotech: Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling
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RT @HeidiRehm: I know many of you have been awaiting us launching transcript expression data in gnomAD. We were waiting for the GTEx v10 re…
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RT @FinnGen_FI: Are you passionate about software development and eager to make a meaningful impact in healthcare? Join our team at FinnGen…
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A new initiative from @ngisweden! OpenLab is an accessible, equipped lab space for genomics researchers to pursue their assays, filling the gap between a service facility and people's individual research labs. Pilot in Uppsala, with hopes to expand it to other locations.
I am very proud to be part of this project. Come and celebrate the opening of NGI OpenLab in January with us. 🧬 🧪
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RT @ngisweden: Single molecule biology 💕 NGS! Today we had the pleasure to host the brilliant @SebastianDeindl where he walked us trough th…
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