Structural Genomics Consortium (SGC)
@thesgconline
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A public-private partnership supporting the discovery of medicines through open science. Sharing our news, science and reagents!
Canada USA Germany Sweden UK
Joined April 2010
We are uniting experts in ML, computational chemistry, and drug discovery to get hands-on experience with AIRCHECK. Co-developed by SGC and @UHN, AIRCHECK is an open data platform designed to enhance predictive models in drug discovery. Register here:
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@mattschap discusses how SGC will emerge as a leading source of open-science protein-ligand data and shares his vision for building stronger connections between data scientists and drug discovery experimentalists at the @UofT through the newly launched CrossTALK Bootcamp.
Data science is driving breakthroughs in countless areas but a lack of availability of experimental training data has limited its impact on drug discovery. Learn about the "Galvanizing Data Science Applications in Early Stage Drug Discovery" project: 🔗
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RT @geordifrere: A rigorous study of UPS tool compounds for #degrader evaluation is published by Stefan Knapp @thesgconline in ACS Chemical…
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RT @TheNeuro_MNI: Researchers at @thesgconline and The Neuro, along with scientists from 11 major antibody manufacturers, have developed an…
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We co-hosted " @target2035 – A Public-Private Partnership to Accelerate Hit-Finding" along with @ucl and @pfizer. 50 leaders from the pharmaceutical industry, academia, and funding organizations discussed how AI and ML can transform drug discovery.
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RT @antolin_aa: #MAINFRAME is launching! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together t…
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We just launched #MAINFRAME! This international, #OpenScience Network brings #MachineLearning & #compchem scientists together to create open-source algorithms & benchmarks for tackling real-world challenges in #DrugDiscovery. Join us:
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RT @JCIM_JCTC: CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein @Che…
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Supported by @UofTDSI, a program led by @mattschap will provide trainees with the skills necessary to interpret complex experimental data and drive breakthroughs in drug discovery. Registration for the first 9-week bootcamp is now open.
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New episode for our Target 2035 Podcast Series 🎧 @MilkaKostic talks with @aledmedwards to unpack his journey from a traditional research scientist to a passionate open science advocate. Listen here:
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A summary of the efforts of @EUbOPEN, a public-private partnership dedicated to create, distribute and annotate the largest openly available set of high-quality chemical modulators for human proteins.
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We have joined the Bluesky community! Follow us to stay updated on our latest research, collaborations, and efforts to shape the future of drug discovery.
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How does EZH2 inhibition make atypical teratoid rhabdoid tumor cells vulnerable to therapy? A collaborative study using UNC1999, a high-quality chemical probe developed through a collaboration between the SGC @UNCPharmacy.
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We report four DCAF1-based PROTACs with endogenous and exogenous WDR5 degradation effects and high-resolution crystal structures of the ternary complexes of DCAF1-PROTAC-WDR5. #PROTACs #DCAF1 #WDR #DrugDiscovery #OpenScience
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A comprehensive study that offers validated ligands for future autophagosome tethering compound (ATTEC) development and advances targeted protein degradation strategies.
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A 2024 update on @Chemical_probes highlights a significant expansion in the number of chemical probes and human protein targets, along with major improvements in expert review processes and user engagement.
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A fully open framework for DEL-ML hit discovery. We replace explicit DEL compound structures with ML-ready chemical fingerprints, enabling the broad scientific community to advance DEL-ML models and refine discovery methods. All data available on AIRCHECK.
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A well anticipated overview highlighting the first CACHE challenge, which brought together 23 research teams from 10 countries to collectively predict 1,955 compounds targeting LRRK2-a protein linked to #ParkinsonsDisease.
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RT @Chemical_probes: 🚨 New publication alert! 🚨 Our latest update on the Chemical Probes Portal is live! 🎉 📜 Read the paper: https://t.co/…
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A news feature by @Nature addresses the longstanding issue of unreliable antibodies in biomedical research and highlights the efforts of initiatives like @YCharOS1. A piece worth reading featuring the amazing work by @laflamme_c58627's group:
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