TEXIMMED2- Freiburg Labs
@teximmed2
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Translational EXperimental IMmunology MEDicine 2 Freiburg Labs of R. Thimme, M. Hofmann, C. Neuman-Haefelin, T. Boettler, B. Bengsch We live(r) immunology
Freiburg
Joined June 2021
@druppygill @Uniklinik_Fr @blizard_inst @BartsHepatology Thanks @druppygill for coming and sharing your expertise.
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RT @AGA_Gastro: Exhaustion of CD39-Expressing CD8+ T Cells in #Crohn’s Disease Is Linked to Clinical Outcome https:…
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7/7: However, Omicron-breakthrough infections induced superior antibody neutralization against Omicron compared to 4th vaccination.
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6/7: Breakthrough infections (after 3rd vaccination) also induced a short-lived CD8+ T cell effector response, which was compareable in phenotype and dynamics to a 4th vaccination.
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5/7: Importantly, this memory pool was already formed after the 2nd vaccine dose and shows limited phenotypic changes after boosting, regardless whether specific memory subsets (TSCM & TCM) or more comprehensive measures to define memory cells (CD127+ & BCL-2) were analyzed.
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4/7: Further analysis revealed the presence of classical memory cells throughout the effector phase upon boost vaccination, suggesting effector responses are built on top of a stable memory pool.
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3/7: Phenotypically, the effector responses induced after each vaccination are indistinctive. Importantly, CD8 T cells with high BCL-2 expression were maintained upon boost vaccination.
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2/7: Spike-specific CD8+ T cells are efficiently activated (CD38+, Ki67+, T-bet high) and expanded by a 3rd mRNA vaccination. This boosting effect lasts approx. 2 months.
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RT @AnnaGlobig: Very happy to see this out in @NatureComms! 🥳🎉 We identify a distinct Tc17 cell population in Crohn’s disease with proinfla…
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Excited to share our work on T cell exhaustion in Crohn’s disease. @AGA_Gastro @AnnaGlobig @Therealbbengsch CD39+ CD8 T cells in the blood are associated with Crohn's activity ⬆️T cell exhaustion 🟰 Crohn's disease activity⬇️ full paper here:
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Next week, he will pass on his knowledge to the next generation at the @EASLedu School in Freiburg.
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#liverimmunology high profile session at the #ILC2022 and filled with experts in the audience. Great fun!
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RT @PlossLab: Very much enjoyed the @TRR179_2 viral #hepatitis conference in @Freiburg. Fantastic presentations by @jschoggins @EJohnWherr…
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@TheBinderLab @fireskyer @JohannHolzmann @fitterhappierAJ @bertoletti_lab Sicher valide Hypothese, die weiter untersucht gehört. @bertoletti_lab ist exzellent. Sehr gute Arbeiten zur Epitop-Diversität und Immundominanz von SARS-CoV-2 spezifischen T-Zellen auch von @profshanecrotty und @SetteLab vom LJI in San Diego.
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@druppygill @BritSocGastro @DrPKennedy @Peppa_Group @maini_lab @bertoletti_lab @pallett_lab @blizard_inst @BartsHepatology Congrats Uppy!
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This is going to be really good! Make sure you do not miss #ILC2022 in London. It's been a loooong time!
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Once again, congrats Maike Hofmann. This prestigious research award is so very well deserved! 👏 @TRR179_2
Unsere Staatsministerin Kornelia Haugg mit den Preisträgerinnen und Preisträgern der Heinz Maier-Leibnitz -Preise 2022. Herzlichen Glückwunsch! 🥳
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@joostphdrenth Thanks all and congrats! Important study for self-monitoring of diet mistakes. Positive tests in placebo arm due to diet mistakes or specificity of the assay?
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