@psybalazs Precisely! It's ironic that researchers branded MDMA a psychedelic so it could ride on the coat-tails of psilocybin hype to achieve FDA approval and now Lykos' failure has undermined confidence in and likely increased FDA scrutiny of the true psychedelics

@FitFounder There can also be a severe cascade effect, as chronically high levels of cortisol from stress can lead to benign tumours of the pituitary or adrenal glands...which then over-produce cortisol even more..leading to resistant hypertension and T2D

@PaulAustin3w But there's a clanking cognitive dissonance in the fact the 'legitimised' psychedelic experience is being provided by venture capitalists and other fro-profit actors who are very much in the extraction business

@FitFounder I agree re value of continuous monitoring. I find periodic tracking of 5-7 days to gauge where I'm at + test new relaxation methods more useful - but will HRV monitor, not PPG sensor

@jonnym1ller A great example of how performance is optimised by the right balance of stress + recovery

@businessbarista Athletic Greens - ubiquitous sponsor of wellness podcasts

@anniepaul @IrvineWelsh A classic and, on a similar tip, Rockers

@BStulberg And a society that prioritises productivity at all times and stigmatises rest as frivolous/lazy

@PaulAustin3w @hdlnii Does the appetite exist for anyone to hear that articulation, however?

@FitFounder We’ve also normalised being over stretched and living in a state of stress while stigmatising the relaxation we need to recover as laziness

@Drug_Researcher @AAMortazavi Go head-to-head vs spravato in MDD or TRD?

@johnnyxbrown Very true - people talk a lot about stress but not about recovery/recharge time. What you think is stress may just be insufficient recovery

Notable that the FDA approved JNJ's version of ketamine despite 'Some committee members noted the trial wasn’t really blind since participants could recognize they were getting the drug .' If double-blinding wasn't an issue then, why now?

@altini_marco Thanks Marco, interested to read your thoughts

@altini_marco I tracked my morning HRV for a few months and found it did not pick up on fluctuations in self-perceived negative stress or days when I was travelling or working late and had little opportunity for relaxation

If the FDA consider MDMA clinical trials 'nearly impossible' to blind, we can all guess how they will respond to psilocybin trials The question is - why has this emerged as a barrier only now and not before the clinical studies were run?

@breath_Guy @hubermanlab @jonkabatzinn I agree - it's a guided body scan meditation with better branding

@DrSianAllen Diabetologists get the use of CGM in their patients and many cardio's use Apple Watch's ECG to diagnose atrial fibrillation. But, in my experience of surveying HCPs, the average doctor has limited experience or interest in wearables and even less time to analyse patients' data

@sequencemyneuro Thank you very much for the response, very interesting

Very interesting. I'd also just flag that an under-recognised driver of poor metabolic health is a high cortisol level, caused either by chronic over-activation of the sympathetic nervous system or a benign (and often un-diagnosed, partic adrenal) tumour of the adrenal/pituatry glands