Molecular biology; Neuroscience

Nature - Unimolecular integration of NMDA receptor antagonism with GLP-1 receptor agonism effectively reverses obesity, hyperglycaemia and dyslipidaemia in rodent models of metabolic disease.

Nature Neuroscience - Intersectional adeno-associated viruses are important for neuroscience research but can be limited by complex and bulky design parameters. Hughes et al. present a unique and...

Serotonin neurons from the raphe nuclei project across the entire brain and modulate diverse physiology and behavior by acting on 14 distinct receptors. Here, we take a step dissecting this complex...

Tian et al. show that ketamine administered within the re-exposure time window alleviates PTSD-like symptoms by reducing BLA engram cell activity. Activation of the VTA to BLA dopaminergic pathways...

Left-right asymmetry of the human brain is widespread through its anatomy and function. However, limited microscopic understanding of it exists, particularly for anatomical asymmetry where there are...

Molecular Psychiatry - Mechanisms of neuromodulatory volume transmission

Nature Communications - How distinct circuits get coordinated to allow individuals to express appropriate level of anxiety is unclear. Here, authors show there are two functionally opposing...

Nature - Oligodendrogenesis is shown to be involved in reward learning, with dopaminergic neuronal activity-regulated myelin plasticity being an important reward circuit modification.

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Norepinephrine (NE), a neuromodulator released by locus ceruleus (LC) neurons throughout the cortex, influences arousal and learning through extrasynaptic vesicle exocytosis. While NE within cortical...

Selective manipulation of neural circuits using optogenetics and chemogenetics holds great translational potential but requires genetic access to neurons. Here, we demonstrate a general framework for...

Abstract ID 93034 Poster Board 149 Despite significant advances in neuroscientific research, the neural circuitry underlying the association between stress and motivation is not clearly defined....

Nature Communications - How the hippocampus selects relevant events that are worth remembering is debated. Here, authors show midbrain dopamine neurons projecting to the hippocampus provide a...

Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-propagating conformations, leading to rapid-onset dementia and death. However, elimination of endogenous PrP...

The establishment and refinement of higher brain functions during evolution require various core brain regions to accurately and efficiently control specific types of memories. Wang et al. demonstr...

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Nature Communications - Elevation of IL-6 during cancer progression has been shown to drive cancer cachexia, however, while brain dysfunction has been reported, the underlying mechanism is unclear....

Recognizing conspecifics in order to determine how to interact with them appropriately is a fundamental goal of animal sensory systems. It has undergone selective pressure in nearly all species. Mice...

Understanding cellular architectures and their connectivity is essential for interrogating system function and dysfunction. However, we lack technologies for mapping the multiscale details of...

Lou et al. identify a hyperactivity noradrenaline pathway from the locus coeruleus to the hindlimb primary somatosensory cortex involved in active-sleep-deprivation-induced pain sensitization....

Psilocybin, ketamine, and MDMA are psychoactive compounds that exert behavioral effects with distinguishable but also overlapping features. The growing interest in using these compounds as therapeu...

Genetically encoded tools for monitoring and silencing neuropeptide signaling in awake mice reveal that neuropeptides in brainstem peptidergic neurons act as primary transmitters, encoding defensive...