Science Signaling
@scisignal
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Uncovering mechanisms in biology, gaining insights into physiology and disease.
Washington, DC
Joined April 2010
Synthetic peptides decode the dynamic, unseen life of the ghrelin receptor, a new Review explores the scientific renaissance in understanding the biology of drug addiction, and more in this week’s issue of #ScienceSignaling.
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Scientists have discovered a distinct pathway that sustains the base-level signaling activities of #Tcell and #Bcell receptors, helping to demystify the intricate machinery that governs the #homeostasis of lymphocytes. @CBM_CSIC_UAM
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In this week’s Editors’ Choice piece, we highlight a study by He and colleagues in @NatureCellBio, showing how smooth muscle cells in the gallbladder promote the repair of biliary ducts. Read a summary:
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Leveraging #peptidomimetics of the G-alpha-q subunit, researchers probe how #Gproteins interact with the #ghrelin receptor and delineate how coupling shifts its conformation and activates the receptor through multiple, dynamic steps. @VUBrussel
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RT @EricJNestler: I am proud to share this new review on The Biology of Addiction that appeared today in @scisignal. It was fun to write th…
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RT @XRBustelo: ✅ Happy to have collaborated with Balbino Alarcón’s lab at @CBM_CSIC_UAM in this interesting work‼️ @ciccancer @usal …
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Scientists have discovered a distinct pathway that sustains the base-level signaling activities of #Tcell and #Bcell receptors, helping to demystify the intricate machinery that governs the #homeostasis of lymphocytes. @CBM_CSIC_UAM
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In this issue's Editors’ Choice piece, we highlight a study by Amisaki and colleagues in @Nature, showing how IL-33 stimulates tertiary lymphoid structure formation in cancer. Read a summary:
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New experiments illustrate how ITAMs in B cell and T cell receptors activate #RRAS2 through GDP-GTP exchange and show how this mechanism supports tonic signaling that sustains #lymphocyte populations. @CBM_CSIC_UAM
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This week’s issue of #ScienceSignaling is out! A new study reveals the complex molecular machinery that sustains B cells and T cells, our weekly Editors’ Choice piece parses new findings about the formation of tertiary lymphoid structures, and more.
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The B vitamin known as #biotin can protect flies and human neurons from the devastating neurodegenerative effects of #manganese toxicity, which is a major environmental hazard for welders and industrial workers. @YunjiaLai @ColumbiaMSPH
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A recent study connects herpes simplex virus and neuroinflammation from #TraumaticBrainInjury to #AlzheimersDisease and finds that blocking the cytokine #IL1B prevents amyloid accumulation in latently infected cells. @KaplanLab_Tufts @TuftsBME
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Scientists leveraged #mutagenesis to parse how the #dimerization of PH-TH domains in #BrutonsTyrosineKinase shapes its activity in B cells and T cells, offering important clues about the signaling properties of this drug target. @VUmedicine
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In this week’s Editors’ Choice piece, we highlight a study by Gu and colleagues in @Nature, showing how hepatocytes in damaged livers escape senescence and form tumors. Read a summary:
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How do viruses disarm cellular antiviral responses? Examining a range of both DNA and RNA viruses—including #HIV1 and #SARSCoV2—scientists find they support replication by suppressing the STING pathway and preventing it from activating #NFkB. @ZJU_China
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Manganese toxicity damages neurons and mitochondria by disrupting #biotin metabolism, but can be reversed with supplements of biotin to prevent #neurodegeneration and #Parkinsons-like symptoms, shows new research in fruit flies. @YunjiaLai @ColumbiaMSPH
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The new issue of #ScienceSignaling has arrived! The B vitamin biotin can shield neurons from Parkinson’s-like symptoms triggered by manganese toxicity, scientists delineate how diverse viruses block a cellular antiviral pathway to replicate, and more.
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New in vitro experiments disentangle the activity of Bruton’s tyrosine kinase—an important drug target in some #lymphomas—and delineate its evolutionary history tracing back to the split between ray-finned fishes and lungfish. @VUmedicine
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Scientists have uncovered how a protein named IRF1 supports the reprogramming of #macrophages to tune the innate immune response, which could inform efforts to predict or alter the functions of these immune cells. @ahoffmann2716 @UCLA
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Repetitive injuries to the brain may contribute to the onset of #AlzheimersDisease by awakening dormant #herpes simplex virus, according to new experiments based on a “brain in a dish” #organoid model. @KaplanLab_Tufts @TuftsBME
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