Sarah Crome also at @sarahcrome.bsky.social
@sarah_crome
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Senior Scientist and Associate Professor | @UHNTransplant, @TGHRI, @UofT Immunology | T2 Canada Research Chair l When I’m not in the lab, I’m on the water.
Toronto, Canada
Joined November 2013
🎉 New Year, New Paper!We're excited to share our latest study led by @KyleReid, demonstrating human IL-10-producing ILC2s can be harnessed in cell therapies. 🧬✨ #Immunology #Transplantation #GVHD #RegenerativeMedicine #CellTherapy #ILC2 #Research
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@tmurooka2 @CIHR_IRSC @BurgenerLab @draliciaberard @drdeannasanter @UM_Immu @UM_RadyFHS Huge congratulations
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RT @sarah_crome: 🎉 New Year, New Paper!We're excited to share our latest study led by @KyleReid, demonstrating human IL-10-producing ILC2s…
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This work was a real team effort, with @colpitts_sarah, our clinical collaborators - Jonas Mattsson, Igor Novisky Basso, Abel Santos Carreira, Tommy Alfaro Moya, as well as many others contributing key insights. Thank you!
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Inhibiting GVHD: In a humanized GVHD model, we show that IL-10⁺ ILC2s inhibit T cell-mediated tissue destruction, whether administered prophylactically or after GVHD onset.
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Will post more in the new year on this new paper from our team. Super excited for this study to finally be out!
Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses @CellReports @sarah_crome
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RT @LabWaggoner: REVIEW: Harnessing the biology of regulatory T cells to treat disease @NatRevDrugDisc @mklevings @…
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This work was supported by @CIHR_IRSC and @NSERC_CRSNG, and made possible by @UHN, @UofT, @PMCC, our incredible collaborators Jonas Mattsson & Igor Novitzky-Basso, and the generous participation of our patients at the Princess Margaret Cancer Centre Thank you!
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