Niels J. Rupp, MD
@rupp_md
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Head & Neck, Oral & Maxillofacial and Genitourinary pathologist. Assistant Professor of Theragnostic Tumor Pathology, combining molecular pathology and imaging
Zurich, Switzerland
Joined February 2021
@WeinrebIlan @ENTpathology However in fusions it might be more difficult. I would rather stick with non-canonical if the finding is extremely rare. For everyone interested, here is the referenced paper to the previous description of EWSR1::MYB fusion in AdCC
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Many thanks to Tina Mauthe and all those involved for this close and excellent collaboration to study this rare tumor disease.
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In addition, eight of nine cases, invisible on PET, showed IHC-ERG+, and an underlying TMPRSS2::ERG gene fusion by next generation sequencing.
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In addition, eight of nine cases, invisible on PET, showed IHC-ERG+, and an underlying TMPRSS2::ERG gene fusion by next generation sequencing.
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@MirunaPopescu13 @DrGeeONE With this kind of morphology, although admittely rare, one should also consider ALK rearranged RCC, as they may show this metanephric adenoma like spectrum.
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@Ruthra3596 Well, with regard to the purely biphasic differentiation thats also a good differential diagnosis. They recurrently harbor ctnnb1 mutations, usually show more stroma and are mainly observed in the major salivary glands.
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Excited to share our work on this type of tumor, just published @Histo_Journal. Expanding the spectrum of low‐grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating HRAS/AKT1 mutations #ENTpath #pathology #openaccess 👉👉👉
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