Punit
@punitbansal14
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Pharmacologist | Drug Discovery | Biosimilars | Disease Management | Mountaineer & Avid Traveler (50+ countries) Tweets are for educational purpose only
Joined April 2011
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Pinned Tweet
#Biocon
10yrs of research, hardwork & patience
The journey of 2 biosimilars from lab to patient
#Trastuzumab
- 2008 to 2017
(1st Indian company to have biosimilar approved in USA)
#Pegfilgrastim
- 2009 to 2018
The results we see today,the foundation was laid more than 10yrs ago
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Uwe Hohn, The German coach of
#NeerajChopra
, is one of the greatest Javelin throw athletes in the history of Sports
Uwe Hohn is the only athlete to throw a javelin 100 metres or more, with his world record of 104.80 m
Image Credit: Wikipedia
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3K
7 Stocks for 7 years
#CDMO
's to watch out for based on
- R&D, IP/Patents, Innovation, Scientists & Therapeutics
Syngene
Neuland Labs
Laurus Labs
Sequent Scientific
Jubilant Life
Dishman Carbogen
Hikal
(not a recommendation, please do your own market research)
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2K
A giant whale approaches an unsuspecting paddle boarder, and the incredible encounter was captured by a drone 🐋 ❤️
Video Credit: Newsner
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Laurus is as sweet as aamras 🥭 if you study the complexity and scale of their filings and patents. This is a behemoth in the making from Indian subcontinent. Structural long term story.
#LaurusLabs
⭕️
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#Lauruslabs
15 yrs of Research, Hardwork & Patience
The results we see today, the foundation was laid more than 15yrs ago
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India completes a hat-trick of medals in badminton at the Olympics 🇮🇳
2012 in London - Saina Nehwal (Bronze) 🏅
2016 in Rio de Janeiro - PV Sindhu (Silver) 🏅
2020 in Tokyo - PV Sindhu (Bronze) 🏅
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North American Energy Drink Industry
~ US$15B market & the fastest-growing non-alcoholic
beverage category, expected to grow at 8.1% CAGR to
US$19.4 billion in 2024
~ Jubilant Ingrevia serve 20+ customers for energy drinks & breakfast cereals globally
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#Praj
CombiFerm-Sugar Fermentation technology
The Extra Productive XP+ yeast strain delivers high ethanol concentration (titer) in fermented mash between 10-15% v/v,enhancing profitability of a distillery/ethanol plant. It can be offered in existing distillery with same results
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Very few
#API
players in the world had the courage and muscle to survive headwinds and climb the mountain of steep learning curve, build awesome technology and capability.
#Neulandlabs
is one such formidable 🌋
CDMO | API | Peptide Synthesis
🔬 🧪 🧫
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Granules of scientific wisdom transports the conviction into New Land where Laurel are evergreen ⭕️
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"Don't tell me you can't" - Paralympian, Juan José Méndez Fernandez is an Inspiration to All
#Paralympics
💙
Image Credit: CapoVelo
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Can you spot me?
..Local rumor says this is the door to hell
Travel has taken me to some wonderful & remote corners of this world and this is at Darvaza Crater - hundreds of km deep within the Karakum desert of Turkmenistan that has been burning from 50 years 🔥
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4 for Para-IV
After lifting the bonnet and checking the wiring, my 4 for Para-IV based on Biosimilars & Para-IV pipeline are
💊Biocon
💊Indoco Remedies
💊Natco Pharma
💊Strides Pharma
(Please do your own market research)
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Just In: Hikal signs a 10-year multi-product deal with a leading global pharmaceutical innovator company
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One of the most spectacular
#roadtrips
in the world. Throwback to this incredibly beautiful & remote corner of our planet off the M41 highway
Either heaven or someplace pretty close to it. Spot me?
Location: Tulpar-Kul at Lenin Peak Base Camp🏔️,
#Kyrgyzstan
#pamirhighway
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Zoetis is dealing with a multitude of animal species in global markets, but has partnered with only 3
#CDMO
capability species in India. These 3 were in my 7 for 7
1. SeQuent
2. Syngene
3. Hikal
🐕🐈
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Image 1: Paracetamol is made by reacting para-aminophenol with acetic anhydride
Image 2 & 3: MS of acetic anhydride in India is 71%, some of top producers of Paracetamol are nearly 100% dependent on them
Image 4: One of the World’s largest Paracetamol API facilities also in 🇮🇳
#Paracetamol
is made by reacting 4-aminophenol with acetic anhydride
#Aspirin
is also produced by reacting salicylic acid with acetic anhydride
#JubilantLife
is dominant player in acetic anhydride with 62% market share in India & 4th largest in terms of merchant sales globally
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ARVs? - Seen
Oncology, Anti-Diabetic, Cosmoceuticals, CVS, PPIs, CDMOs etc..🧪 - Can be seen with Ophthalmic drops 👁️
Recombinant - Unseen & Unimaginable 🧬
Science of
#LaurusLabs
will continue to delight
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From a 1 product company in 2010, now present in 3 business verticals API, FDF & CDMO having 6 manufacturing units with a total of 751 reactors with 3615 KL capacity & 5 billion tablet/capsules -
#Lauruslabs
transformation in a Decade
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#Lauruslab
is the 'Intel Inside' for Pharmaceutical API, CDMO, Nutraceutical & now for the Cosmeceutical Industry
#Bakuchiol
an anti-aging product for the US market👌
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"Biotechnology is creating a new industrial revolution based on Biology instead of petroleum. As Biotech processes replace old rust-belt technologies, they are enabling a transformation from a petroleum-based economy to a Bio-based economy"- Brent Erickson
Image Ref:
#Praj
Ind🧬
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Bio-Acetaldehyde - Bio based 🧬, World’s largest manufacturer from 🇮🇳
Image 1: Benefit in carbon footprint as compared to the conventional petroleum route
Image 2: Bio-Acetaldehyde business overview
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Brian Lara 400 not out
#LaurusLabs
450 not out
Test match player of exceptional talent and temperament 🏏
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@unseenvalue
@AdityaKhemka5
@tusharbohra
Laurus, Neuland, Sequent, Syngene, Hikal (CDMOs basket), No recommendations
“Medicine heals doubts as well as diseases.” - Karl Marx
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#Lauruslabs
has out-licensed its patented technologies to one of the top Nutraceutical players in the US
Laurus has filed 264 patents & been granted 130 as of today
IP is the backbone of innovation in the pharmaceutical industry
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Oncology testing is a $75B market with only 4% penetration
Genomics will improve care across the cancer journey
Ref:Illumina,J.P. Morgan Healthcare Conference,Jan'22
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#SeQuent
changing orbits in a SeQuential manner. The unseen capability of filings & CDMO will be seen over time 🐈🐕
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#Lauruslabs
has filed 26 ANDAs in the US out of which 9 are Para-IV.
Out of these 9, 7 are first-to-file (FTF) opportunities having an addressable market size of over $10 billion👇
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Tri-Kal vision of Hi-Kal. Past is misleading. Future is leading...
Human ⭕️ Agri ⭕️ Animals ⭕️
💊 🌱 🐕
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'I want to b remembered as someone who put India on Scientific map of d world in terms of large innovation.I want to b remembered for making difference to global healthcare&I want to b remembered as someone who did make difference to social-economic development in🇮🇳'-Kiran M Shaw
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Neuland labs API brain in Donepezil🧠
Pic1:Q3-filed USDMF for donepezil base
Pic2:Q4-Speciality business led by donepezil etc
Pic3:Patent,SR inj. formulation of donepezil sample taken from Neuland
Neuland & Perrigo only 2 cos have USDMF for both donepezil base & donepezil HCl
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#Lauruslabs
has a licensing agreement with The Medicines Patent Pool (UN-backed public health organization) for the following molecules👇
💊Bictegravir
💊Dolutegravir
💊Emtricitabine
💊Tenofovir alafenamide
💊Daclatasvir
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In FY2022, we are aiming (a) Top position globally in Zinc Pyrithione (ZPTO) & develop pyridine-based technology for the synthesis of Octopirox, (b) Broaden the scope of our existing product....... Jubilant Ingrevia AR2021🇮🇳
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Ethanol 🧬 Bioethanol
Methanol 🧬 Biomethanol
Acetic acid 🧬 Bioacetic acid
Acetaldehyde 🧬BioAcetaldehyde
Chemicals 🧬Renewable Chemicals
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#SeQuent
journey from FY15 to FY20 has many unseen numbers👇
From FY21, A New Frontier 'Growth Catalyst' will be API
#CDMO
- ‘One Stop Solution’ for all API needs of global leaders 🐈⬛🐃🐕
@unseenvalue
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Future of
#API
Industry 💊💉🐕
API - Active Pharmaceutical Ingredient
API - Animal Pharmaceutical Industry
API - Antibiotics Plus Intermediate
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Bitumen is a black viscous mixture of hydrocarbons produced by fractionation of crude oil (Petroleum based)
#Praj
proprietary process (under patenting) to convert crude lignin to Bio-Bitumen which has potential to replace fossil-based Bitumen & offer eco-friendly green Bitumen🧬
"Biotechnology is creating a new industrial revolution based on Biology instead of petroleum. As Biotech processes replace old rust-belt technologies, they are enabling a transformation from a petroleum-based economy to a Bio-based economy"- Brent Erickson
Image Ref:
#Praj
Ind🧬
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Simple ABCDE of
#Lauruslabs
A - ARVs & APIs
B - Biotechnology
C - Cardiovascular drugs & CDMO
D - Diabetic drugs
E - Excellent interview by
@_nirajshah
📽️
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Indian Nutraceuticals market constitutes nearly 2% of the global
#nutraceuticals
market & expected to grow with 21% CAGR & account for 3% of global share by 2022👇
US, Europe & Japan account for >90% of the global nutraceuticals market (Source: Deloitte)
Heard of any industry growth at 20% CAGR?🤔
Invest 5 min and read it to know the industry trend and growth of Indian Nutraceuticals industry
@drprashantmish6
@unseenvalue
@punitbansal14
@PrasadWakchaure
@npal20
@Harrshit1
@ketanmba03
@AnyBodyCanFly
Pls add ur valuable comnt🙏
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The demand for specialty alcohols (ethanol) used in a wide range of consumer & commercial products has risen in global market🧬
Image 1: US annual sales of cleaning products ($bn)
Image 2: Industry value chain in Pharma & Agro
Image 3: Speciality alcohol business (8% MS)🇮🇳
Feedstock +
#Fermentation
= transform into specialty alcohols used in a wide range of consumer & commercial products 🧬
-GNS/Food & Beverage
-API Grade Alcohol
-USP Grade Alcohol
-Industrial Grade Alcohol
-Ethanol (Renewable Fuel)
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Feedstock +
#Fermentation
= transform into specialty alcohols used in a wide range of consumer & commercial products 🧬
-GNS/Food & Beverage
-API Grade Alcohol
-USP Grade Alcohol
-Industrial Grade Alcohol
-Ethanol (Renewable Fuel)
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When you reach this panorama after a grueling drive. Lesser-known Nature parks are such a revelation
This country is the home to mesmerising glacial lakes-polar blue expanses of striking clear water surrounded by skirts of pine
📍Piva Lake & Durmitor National Park,
#Montenegro
🇲🇪
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Image 1: Ophthalmic range i.e. Timolol, Latanoprost, Dorzolamide,etc. are increasingly finding global acceptance
Image 2: CEP approvals in EU
Image 3: Read highlights & focus areas
Image 4: Export business
Link 1: 14 of 18 are ophthalmic products in UK
Pharma Ophthalmology - Strong market opportunity⤵️
👁️Aging population with growing eye care
👁️Myopia prevalence is growing; increased screen time mobile📱
👁️Half of the world, ~5b people, will be myopic by 2050
#API
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The great Pamir Highway road trip. From
#Kyrgyzstan
to
#Tajikistan
via the Wakhan Valley. Following the ancient silk route that was used for many centuries
Location: Karakul Lake in Tajikistan at an altitude of 3960m
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Top companies in Animal Health🐪 (as of Nov 5, 2021)
Reference: S&P CapitalIQ & Torreya research
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Complex APIs, CDMOs and Biotechnology spaces are in a long term structural uptrend 💊🧬🔬
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Read, Spot & Analyze the difference in Image 1 & Image 2 paragraph
Image 1: Hikal AR 2018, Page 29 (under CDMO business)
Image 2: Hikal AR 2020, Page 34 (under CDMO business)
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#SeQuent
received the world’s largest injectable Tulathromycin approval within 11 months of filing in the European market during Q2FY21👇
Zoetis blockbuster novel antibiotic Draxxin (
#Tulathromycin
) is a very large product in the animal health with over $300 mn market
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#Lauruslabs
is a research-driven Pharmaceutical & Biotechnology company
2016 : IPO @ 426-428
2021 : 428 + Genetically engineered recombinant technologies 🧬
#Lauruslabs
15 yrs of Research, Hardwork & Patience
The results we see today, the foundation was laid more than 15yrs ago
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#Praj
Hipurity systems offering to Human & Animal Vaccines🧬
Image 1: Diphtheria & Tetanus process
Image 2: Pertussis process
Image 3: Cell culture-based Rabies vaccine
Image 4: Animal vaccine process
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Unseen future of
#Laurusbio
🧬
By harnessing the power of integrated enzyme
#fermentation
for the production of Ethanol (Biofuels)⛽️
"Richcore will be renamed to Laurus Bio shortly🙂"
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Ethyl acetate (EA) is an efficient green solvent & its wide range of applications👇
Pharmaceutical
Surface coating & thinner
Adhesives
Rubber & polymers
Flavors & essences
Nail polish remover
Decaffeinating of Tea & Coffee
#JubilantLife
is 7th largest mfg of EA in the world
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Talent propels business success 🧬
WuXi Biologics is having 516 employees holding Ph.D. or equivalent (7.7%) - Total employees 6646
#Syngene
is having ~460 employees holding Ph.D. (9%) - Total employees ~5000
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The Dream of a Lifetime -
#Tibet
Mt Everest north face as seen from
#Rongbuk
monastery, the highest monastery in the world at an altitude of about 4980 meters (16,340 ft)
Heading to
#EverestBaseCamp
- Tibet🏔️
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“Everyone wants to live on top of the mountain⛰️, but all the Happiness and Growth occurs while you’re climbing it.” - Andy Rooney
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CDMO case study research
Image 1: Development&clinical supplies of a complex triple API combination hard-chew tablet for animals
Image 2: Simparica Trio (Sarolaner/
#Moxidectin
/Pyrantel) the first&only combination chew with moxidectin
Image 3: Wins Best Companion Animal Product
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The 7 Scientists who participated in the Tokyo 2020 Olympic Games
Anna Kiesenhofer, PhD Mathematics
Hadia Hosny, PhD Pharmacology
Charlotte Hym, PhD Neurosciences
Gabby Thomas, Neurobiology
Louise Shanahan, pursuing PhD
Nadine Apetz, MS Neurosciences
Andrea Murez, Biologist
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#Laurus
established a leadership position for itself in mfg.of polyphenols. Laurus developed technologies for β-carotene, Astaxanthin, Huperzine A & novel
#nutraceutical
cocrystals of Pterostilbene, Caffeine& Curcumin with enhanced bioavailability&controlled absorption properties
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#SeQuent
is the only USFDA approved veterinary API facility in India with a robust portfolio of APIs👇
US Filings/Approvals: 19
CEP filings: 11
Commercial APIs: 27
10 new filings in the US in next 3 years with a market size of over US$500 mn+
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Image 1:Global Parkinson’s disease treatment mkt
Image 2:Global Entacapone API mkt
Image 3:Global 3,4-Dihydroxy 5 Nitrobenzaldehyde (Intermediate), Ami organics hold MS of ~45-50%, sale of ~30MT in FY21
Image 4:Neuland labs specialty business in Q4FY21 led by Entacapone etc..
Impact of
#COVID19
on Parkinson's Disease (PD)-Neurodegenerative Disorder🧠
A concept map highlighting key direct, indirect & drug therapy correlations between COVID19 & PD patients
#Entacapone
,a selective & reversible inhibitor of enzyme COMT
Image Ref:J Clin Mov Disord.2020
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Unseen future of
#Laurusbio
🧬
"We are gearing up to do is create a large scale recombinant capacity to do proteins for food industry and proteins for therapeutics"
Fermented proteins demand forecast, Market for probiotics & enzymes within consumer health (Ref: Novozymes)⤵️
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Clean Sugar Market
New sugar demand growth is being driven by Biology focused companies who use sugar as a feedstock for their bioprocesses
Growing demand for fermentation to produce a variety of products without petroleum additives requires Dextrose/Glucose
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"We are on course of commissioning large scale Fermentation capability. We are also planning to acquire additional land for further expansion by creating close to million litres
#Fermentation
capacity" Laurus Labs AR 2020-21
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Unseen growth in
#API
segment revenue for Indian pharma companies in FY21 🇮🇳
Excellent compilation of data by the Perpetuity team👍
Tweet Credit:
@Perpetuity_H2W
⤵️
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Pause exactly at 1:27:33 and think about the land of opportunities
Excellent presentation on
#pharmasector
by Abhishek Singhal👍
@Perpetuity_H2W
@varinder_bansal
@omkaracap
OMKARA PATHSHALA: THE BASICS
"PHARMA SECTOR" with Abhishek Singhal
20 years of experience in 2 hours. Watch to simplify all the jargon in the pharma sector. Invest for free in yourself.
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Just In: FDA approved LUMAKRAS™ (Sotorasib) from Amgen, The first & only targeted treatment for patients with KRAS G12C-Mutated locally advanced or metastatic non-small cell lung cancer
#Syngene
was a part of a scientific breakthrough by the clients - Development of KRAS inhibitor drugs
Amgen aims for first KRAS inhibitor approval in the US
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The top 5 therapy areas in 1995 & the top 5 in 2020 changed dramatically over the period
The top five therapy classes in 2020 (Oncology,
Immunology, Anti-diabetics, Anti-coagulants, & HIV
Anti-virals) have grown from 11% of spending in 1995
to 62% in 2020
Ref: IQVIA Dec'20
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Coffee ⬆️+ Ethyl acetate ⬆️= Decaffeinated Coffee ☕️
Ethyl acetate (EA) is an efficient green solvent & its wide range of applications👇
Pharmaceutical
Surface coating & thinner
Adhesives
Rubber & polymers
Flavors & essences
Nail polish remover
Decaffeinating of Tea & Coffee
#JubilantLife
is 7th largest mfg of EA in the world
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A laboratory is a facility that provides controlled conditions in which scientific or technological research, experiments and measurement are performed.
Please avoid using word 'BOGUS' instead 'FOCUS' 😉
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#DanakilDepression
-one of the hottest & most inhospitable places on Earth
#Dallol
a martian kind of landscape formed by volcanic explosion & subsequent hydrothermal activity - the resulting psychedelic salt formations makes you feel like you're on a different planet
📍Ethiopia
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#Jubilantlife
signed 5 new deals related to COVID-19 treatment & vaccines with potential revenue of up to ₹500 cr over the next 12-15 months in Q2FY21
Under CMO business, Sterile injectables account for 80% while non-sterile products account for the balance 20% of CMO revenues
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#Syngene
and Deerfield Discovery and Development (3DC) sign 5-year
strategic collaboration🧬🧬
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China's share of CEPs for high-volume
#APIs
is lower than India
India % China %
Propofol 40 0
Metformin 82.6 4.3
Levetiracetam 57.1 38.1
Venlafaxine 71.8 12.5
Quetiapine 62.0 10.3
Ramipril 64.7 17.6
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Laurus Labs + Boehringer Ingelheim Pharma = Product of India 'Ophthalmic Drops'🇮🇳
ARVs? - Seen
Oncology, Anti-Diabetic, Cosmoceuticals, CVS, PPIs, CDMOs etc..🧪 - Can be seen with Ophthalmic drops 👁️
Recombinant - Unseen & Unimaginable 🧬
Science of
#LaurusLabs
will continue to delight
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Image 1&2:EU-CEP approvals in 2021 sofar
Image 3:API +ve outlook for H2 with growing order book&recent agreement with ‘Top 10’ to drive FY23
Image 4:We are achieving significant progress in expanding our portfolio through value-added arrangements for
#vaccines
in Turkey & India
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Ethanol yield & pricing across feedstock 🧬
Feedstock (Image 1: Gov Doc)
- Sugarcane juice/Sugar/Sugar syrup
- B Molasses
- C Molasses
- Damaged Food Grains (Broken Rice)
- Rice available with FCI
- Maize
Change in Ethanol pricing across feedstock (Image 2): The Hindu Business
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What started as a simple
#API
& PFI story over 3 decades ago, is transforming into a serious technology integration -
#Granulesindia
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Batch-mates, Mr Newton and Miss Laura are having a gala time. They have proven track record in the field of science and innovation, but markets only proposed them recently. Fun and carnival lies ahead
Come to their party invitation 🎈 🥳
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Growing spend on Pet family members in the US 🐕🐈
US spends $99.0 billion a year on pets
US spends $1.7 billion a year on pets on Valentine’s Day presents for pets
US spends $490 million on Halloween costumes for pets
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Heathrow becomes first major UK airport to incorporate sustainable aviation biofuel into operation 🌾✈
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