Pashtoon Kasi MD, MS
@pashtoonkasi
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Oncologist |Researcher| ColorectalCancer #CRCSM👨🏼🎓@MayoClinic @PittTweet Alum 🧬#ctDNA #LiquidBiopsies #PrecisionOncology @CityOfHope Views my own-COI @ASCO
Irvine, CA
Joined May 2012
🆕🗞️Just out.🪺#NEST-1 trial results👇🏾. Are we on the verge of a new drug combo for colon or rectal cancer?. Substantial & brisk responses to just☝🏾dose of BOT🟢➕BAL🔹🔹 immunotherapy.🙌🏾. Pattern & kill is unprecedented🌊. @ASCO #GI24 @OncoAlert.Abstract 117📍Poster Board H2
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What is the #CityOfHopeDrug?. A pill💊that can kill all #cancers. I have been asked the "killer-pill" question several times this week. What is the hope or the hype?. Let’s learn together:.👇Here’s a tweetorial: @OncoAlert . Press release: August 1, 2023:.
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🗞️@Forbes Published today!. Are we on the verge of a new drug combo for colorectal cancer?. Read more about our work on this immunotherapy called the BOT (Botensilimab). We describe this “inside-out”🌊 wave of regression by immune cells. @TheAlexKnapp.
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Published today! 📰 .@NatureMedicine. One of the first #cancer vaccines💉that target #KRAS. Not just G12C. 👇🏾The 2-peptide was G12D & R. The 7-Peptide/Elicio targets.D.R.V.S.A.C.G13.➕.NRAS. Implications for so many patients!.Open now. Cheers!.@OncoAlert .
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Worst nightmare as a patient/oncologist is to deal with brain🧠metastases. Most drugs don’t penetrate the blood brain barrier & trials often exclude these patients. 👇🏾Our patient with a near complete response after just 1 dose of T-DXd.🙌🏾👏🏾🙌🏾👏🏾. #Cholangiocarcinoma #HER2➕➕➕
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🆕@TheLancet - Colorectal Cancer. Almost 2 years of effort. Finally in print! @UIowaCancer @MayoClinic @MayoCancerCare @mikewallacemd . #CRCSM #ctDNA @IntMedatIowa #clinicaltrials #lancet #seminar #cancer #CancerAwareness.Link to free full text/share 👉🏼
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#Cancer Treatment’s New Direction. My patient care story narrated at The Wall Street Journal @WSJ #WSJ. #throwback .I recently had the privilege of writing a letter of recommendation for him to apply for school! 💡My 1st #PrecisionMedicine 🧬experience. 📌
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I went up to see two of my patients with cancer starting on clinical trials today. As they took their pills, they both broke into tears. Didn’t realize that it’s such an emotional moment for our patients with cancer. Trials bring hope. I was so glad to share these moments today.
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Delighted to share that we are moving to #NewYork🗽!✈️Journey begins today. Joyous & excited to join @WeillCornell. Opportunity to be director for #colorectalcancer & 🧬#precisionmedicine director @WCMEnglanderIPM for #LiquidBiopsy🩸 Research🔬. 🙏🏽@IntMedatIowa for the support.
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🆕Just published! 🗞️ 📰 . Are we on the verge of vaccinating against #CANCER?. Our KRAS vaccine💉study just presented in Chicago picked up by the @DailyMail. 👇🏾Read all about it. 💡The biggest advance post pandemic are the different cancer vaccines.
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🔊Just out🗞@JCO_ASCO @ASCO. 🩸#LiquidBiopsies.🧬#ctDNA in the clinic. Review on #ColorectalCancer.Implications for other cancers.📚Primer to keep.🖊Authors @MallaMidhun @jonathanloree @pashtoonkasi @aparna1024. #OpenAccess @OncoAlert @DrawImpacts #CRCSM.📝
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Our #liquidbiopsies #ctDNA paper now @Nature_NPJ @Nature @nresearchnews. #Cholangiocarcinoma #hpbcsm #bileductcancer ➡️Target Rich but often lack of a good tissue biopsy (ERCP/EUS) to do genomic testing. #PrecisionMedicine #IndividualizedMedicine #Cancer .
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Welcome to the world Zuha ☀️ ضحی .“The time between sunrise and noon”.“Morning bright”.The name we picked earlier, the time she aptly picked herself. Both mom and baby girl are doing fine. 🙏🏽
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#ColorectalCancer is on the rise especially in young individuals. Preventable/can be screened for. Age of screening now moved to 45 years @AmericanCancer. In #Pakistan screening in general is poor for all cancers. Need to increase #cancerawareness✅#CRCSM
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My wonderful patient wanted to make sure I had a good breakfast on a busy clinic day.😊
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🆕 Paper published today!. 💡Can we use #liquidbiopsies to assess #immunotherapy response early❓. Not☝🏽but 2 ways:.1️⃣ #ctDNA kinetics VAF% .📈progression 🆚 response📉2-3 weeks into treatment!.2️⃣Plasma-#MSI; not tissue but🩸 MSI✔️➡️✖️💭 . @OncoAlert @ASCO.
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Post-pandemic, a lot of progress in the🌍of #cancer is about #vaccines💉. 📆🕗Saturday morning, we unveil the results of this novel #KRAS vaccine👇🏾. 👏🏾Amplify-201 ELI-002 . Who’d have thought the letters🔠after KRAS🧬would matter!. #ASCO23 @OncoAlert .🔗
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🗓👇🏼#March1st #colorectalcancerawarenessmonth has started. 💡What’s intriguing is the recognition that #colorectalcancer is actually a group of very different cancers. Even the side of the #cancer (RIGHT🆚LEFT) changes how we treat. Important to know 🧬🔬. #CRCSM #SundayThoughts
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After a long day of clinic, #ChatGPT helped me write✍️ a letter of medical necessity to an insurance company.😅. 🤗🤖 @OpenAI ✅👍🏾. #Cancer #Doctor #PatientCare #MedTwitter
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“Back of the napkin” drawing my patient made of his #anatomy & #cancer while waiting for his appointment. #MedTwitter ✍️
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What else would you add to this slide?🤔 . I prepared this for a talk today to @oncologynursing @CCO_Education. Find it useful to remind myself of the key 🔑 biomarkers to test for each GI cancer for which there’s at least an approval/guideline recommendation. #MedEd @OncoAlert
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One of the most important findings unveiled @ESMOWorldGI. 🎯 #HER2⛔️in #ColorectalCancer . #Mountaineer🏔study with .💊 TUCATINIB➕TRASTUZUMAB. ✅New Standard of Care.OS~2 years!. Ecstatic to have contributed to a new option. 🙏🏽 patients. #CRCSM . #WCGIC2022 @myESMO @OncoAlert
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👇🏾I’m seeing papers calling this the molecule⚛️of the century. Fibroblast activation protein (FAP) inhibitor (FAPI) PET☢️Scan is based on molecular targeting of the FAP expressed in #Cancer-Associated Fibroblasts (CAFs). @Radiology_rsna @OncoAlert 💭.
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🆕 @ASCO #ASCODailyNews ✍🏽 . 🧬#ctDNA Assays: Exploring Their Clinical Use in Oncology Care. 💡👏🏾Let’s explore how these #LiquidBiopsies are being incorporated into every phase of #cancer continuum.🔬🩸. #PrecisionMedicine #OncoAlert #MedTwitter #Genomics
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Perfect timing for the study to be published @NEJM. #ctDNA🩸blood test for screening for colorectal cancer.✔️83% sensitivity.✔️90% specificity. March is #ColorectalCancerAwarenessMonth. 🩸is more practical 🆚 colonoscopy or 💩 test. Unmet need. @OncoAlert.
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👇🏾🆕See our new paper @JCO_ASCO🗞️ . “🧬#DPYD Testing:.Time to Put Patient Safety First”. Such a timely topic for @ASCO to highlight. Glad to be on the right side of history. Every institution has deaths/severe adverse events. Not all recognized. @OncoAlert.
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🆕 Just published @NatureMedicine @Nature. Editorial on✍🏽 .#LiquidBiopsies & the Tumor Mutational Burden cutoff conundrum. 🩸Blood-TMB or plasma-TMB cutoffs need to be harmonized; across platforms, & tissue🆚 liquid. 💡Thoughts?. @OncoAlert #ESMO22.
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Woke up this morning to a #ctDNA showing a deleterious #BRCA1 frameshift alteration that’s deliterious for a patient with advanced/metastatic/symptomatic #cholangiocarcinoma. Started off as an unknown primary (#CUP) & hypercalemia 🦴of malignancy with confusion🧠. Test 💯 🧬🩸🎯.
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1️⃣5️⃣0️⃣ papers📝now on PubMed.🙌🏽. 👇🏽Great for this paper as the personal milestone. Building upon🔬research/clinical focus:. ✔️Developing novel therapies for our patients with colorectal & other cancers.✔️#ctDNA & biomarkers 🧬. @OncoAlert @NatRevClinOncol.
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Which #clinicaltrials or studies caught my attention 👀 @ASCO #GI22❓. 👇🏾Here’s a🧵. Please feel free to add more studies to this 🪡 . Shoutout to ASCO’s featured 🗣 & @OncoAlert.
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#GI22 @ASCO.✍🏽Here’s the breakdown of the 2 most🗣#clinicaltrials #HPBCSM. 1️⃣TOPAZ-1 #BiliaryTractCancers #Cholangiocarcinoma PDL1⛔️ 2️⃣HIMALAYA #HepatocellularCarcinoma #HCC CTLA4⛔️+PDL1⛔️ . Practice changing? @OncLive @OncoAlert
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My 5-year old son heard me say FOLFOX 🦊 during a call today and his enthusiasm about what I do has increased. #workingfromhome.
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We need newer tools to assess response in an era of #immunotherapy & novel 💊. #PrecisionOncology. Scan report says “worsening”/“progression”. The size of the battlefield may appear to be bigger, but the number of soldiers are more dead inside. 💡The hollow/cavitation➡️response.
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dMMR/MSI-High Advanced #ColonCancer with response to single agent #immunotherapy in a nonagenarian. Just 1 dose & the #cancer is melting away. #ctDNA has turned from➕➡️➖. Plasma-MSI also initially “high” & now “not detectable”. Will become a non-surgical disease. #WatchANDWait
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Starting this month; 2 new milestones. ✔️Got word about promotion to Associate Professor. 👨🏻🏫.✔️Going back to school 🏫 in parallel to complete my Ph.D.👨🏽🎓. #LifelongLearning #MedTwitter.
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This is huge👇🏾. 5️⃣th #AGNOSTIC approval for #Cancer. ALL SOLID TUMORS❗️. Outside of the #CRCSM & EGFR⏫story, .#BRAFV600E has been shown to be actionable➡️RAF/MEK⛔️blockade. 👏🏾 great news for patients with #BRAF. Have been waiting for this! . @OncoAlert.
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#MondayMotivation.Got an 📧 this morning from a former metastatic #pancreascancer patient who I started on #immunotherapy Jan’19 based on🩸#ctDNA. Her cancer is NOT❌ visible anymore🙌🏾. She was given a couple of months. Now > 2 years👏🏾. #PANCSM #Thankful .
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Did you grab your copy of the newspaper today 🗞 ☺️
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“Accepted for publication without amendment.” 🙌🏾 ✍🏽 👏🏾.
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Just got formal✅📧of funding for a #clinicaltrial. I’m going to be developing a new 📚- investigator initiated clinical trial - for neoadjuvant therapy for patients with colon cancer involving immunotherapy. #MedTwitter #OncTwitter .💡Please help me with the name of the trial:.
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🙏🏾 @oncodaily - onwards and upwards ✈️. I’m thrilled to begin my new role as Medical Director of GI Medical Oncology at the City of Hope Orange County!. With a focus on elevating patient care, driving innovation through novel therapies, advancing education, and achieving better
📢Dr.@pashtoonkasi has started a new position as Medical Director GI Medical Oncology at @cityofhopeoc!. #Cancer #GIOncology #Career #MedNews #Health #Medicine #MedTwitter #OncoDaily #Oncology.
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#FundRaising #CancerResearch 🔬 .We are building our lab focusing on #research on #cancer 💡using #liquidbiopsies🩸🧬#ctDNA. Hoping for everyone to contribute. Help us reach our goal🙌🏾➡️Donate❗️.🗣Share with family/friends. No amount is too small.🙏🏽.Link:
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#ASCO21 From a personal and professional standpoint, I don’t like #virtualconferences. If it’s a weekday I have this #guilt that I could be seeing patients. On a weekend, at home, I have #guilt again about being distracted around family. 🤷🏻♂️ .#WorkLifeBalance #Burnout #MedTwitter.
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Today I give a talk on #Peritoneal metastases from #ColorectalCancer. I’m hopeful we will have a breakthrough just like we had for #LynchSyndrome who did worse/not much options. Now➡️#immunotherapy cures them. 💡Biology: CMS-4⬆️👇🏾.Don’t miss actionable opportunities. Test 💯.
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🆕#HappeningNow🗞️. I have my own bias/conflicts; but here’s👇🏾one of the most important waterfall💦 plots @ASCO #ASCO23. @EileenMOReilly. 💡A #KRAS #Vaccine💉. 🔠🎯.KRAS-G12.D.R.V.S.A.C.➕KRAS-G13D.➕NRAS. ✅Implications for so many #cancers. @OncoAlert.
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👇🏾👀 at my new office at the 🏥🗽. It also has a window🪟. ☀️😊.#Smallvictories #Motivation #BackToWork . @OncoAlert #MedTwitter #NewYork
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Doubling of disease free survival in a disease like esophageal cancer in patients who have residual disease post trimodality therapy is indeed practice changing. 2️⃣2️⃣months.🆚 .1️⃣1️⃣months. Out @NEJM @OncoAlert. #ESOCSM #VisualAbstract #Research #Cancer #Immunotherapy @sitcancer
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🆕Today📰🗞@WashingtonPost. 💡Read about how #telemedicine📱🖥 was a blessing for so many of our #patients with #cancer seeking out-of-state 2nd opinions/#clinicaltrials. We need to #advocate ✅#telehealth, the only silver lining of #COVID19 #pandemic.
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While we talk about time & financial toxicity, ☝🏾thing that’s finally official after a lot of advocacy is . OXALIPLATIN. 1️⃣mg/m2/min.🆚.arbitrarily over 2 hours➖1️⃣2️⃣0️⃣ minutes. 👍🏾@AndreaCercek Dr. Saltz @ASCO @JCOOP_ASCO 2016!. Let’s challenge dogma!.Let me know if you do this.
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#GI22 @ASCO.1st prospective hints of #ctDNA #MRD #MinimalResidualDisease being beyond just prognostic in #CRCSM #ColorectalCancer. If you cleared #ctDNA➕➡️➖, you conveyed their risk similar to those who were negative. Adjuvant chemo works! 🟢➡️⚫️@OncoAlert
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We grossly underestimate how quickly #immunotherapy can work. Especially with BOT/BAL (botensilimab) in our NEST🪺trial we are seeing💡#ctDNA decline📉 & CLEAR➕➡️➖within days to 2-4 weeks. Unprecedented!. 📆March is #ColorectalCancerAwarenessMonth .
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NEST-1 is now officially open✅. My goal has been practical #clinicaltrials with no crazy mandatory stuff to make it easier for patients & treating physicians. Yet with robust correlatives #ctDNA. Building upon neoadjuvant NICHE-1 @MyriamChalabi #CRCSM.
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Yes 🙌🏾 .You read this right:.MSI⬆️ #PancreasCancer #ctDNA🩸 🧬 . …median PFS & OS were NOT REACHED in this cohort. …among the 9 patients treated with ICI, 7/9 were alive at the time of data cut-off…. 1 who went for surgery➡️pathCR! . #PANCSM @jitcancer #JITC #PANCSM @OncoAlert
New #JITC short report: Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer @pashtoonkasi @doctorC369
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🆕@ASCO_pubs.As we start #ESMO21 @myESMO, see the FOCUS4-N randomized 🇬🇧trial published today alongside our editorial:. 📝 . MAINTENANCE therapy.🆚.Treatment HOLIDAYS. Worth the💰? 👀👇🏾comparison ē other #CRCSM #clinicaltrials. What do you do? @OncoAlert💡.
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Recently I asked if the #cholangiocarcinoma had “fancy markers”? . 💡What are the fancy markers?.➡️“actionable” ones. ✅FDA approved/@NCCN, Or.✔️good #clinicaltrials/off-label options. 30-45% chance. What else would you add?. My last 4: #BRCA2/IDH2, #IDH1, #BRCA2 germline, CCNE+.
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#Fusions cannot be detected on #LiquidBiospsies 🤔. Is that a myth?🐉.We’ll🔜 find out. Come to our poster presentation 🏃♀️ 🏃♂️ #ASCO23 @isliquidbiopsy @OncoAlert.#ctDNA🩸🧬🤝 🕗 5️⃣9️⃣. Focus on🎯#FGFR➕other🔗🧬. Implications➡️many tumor types & therapies💊.
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👇🏾Just happened. ✅@verified on @Twitter. #MedTwitter💡🩸🧬🔬🧪💊💉🩺.#ctDNA #CTCs #LiquidBiopsies #PrecisionMedicine #SmallVictories
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🆕My📝 @ASCO📰 . 💡“Kinetics of #LiquidBiopsies in Predicting Response to #Immunotherapy.”📉🆚📈💭. @ASCO_pubs #ASCODailyNews. 🙏🏽@ASCO . #ctDNA🩸🧬 #CRCSM #PANCSM #LCSM #BCSM #oncology #Cancer @OncoAlert #CancerResearch #PrecisionMedicine #Research #Hope .
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🆕As of April 2024, our liquid biopsy #ctDNA results🔢show up directly in the electronic medical record of a patient just like any other routine lab. This is a huge step for our patients and all physicians to be able to see these results realtime/easy access.🙌🏾. #LiquidBiopsies
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🆕Published now @TheLancetOncol. The Mountaineer🏔️ Study. Excited to be a part of a study that led to a new option for our patients with.🎯 HER2➕#ColorectalCancer. @NCCN✅.1st @FDAOncology✅option for #CRCSM. PFS 8.2m. Median OS~2 years!. @OncoAlert .
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#Fusions cannot be detected on #LiquidBiospsies 🤔. Is that a myth?🐉.We’ll🔜 find out. 👇🏾Looking forward to my 1st ever🗣 presentation #ISLB2022 @isliquidbiopsy .#ctDNA🩸🧬🤝. Implications➡️many tumor types & targeted therapies 💊.#FGFR.#ALK.#ROS.#NTRK.#BRCA.#BRAF.etc.@OncoAlert
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👇🏽One more option for our patients with #ColorectalCancer. While some drugs are for all, other advances are where tumors harbor the target🎯. More like lock and key. 🔐 . 💡Continuum of care improving survival📈. #KRASG12C⛔️#SotoRASib💊 . @OncoAlert. 🔗
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I truly believe in all the advances happening for our #cancer patients. Less than 3 months ago, pt ē widely metastatic (👇🏼innumerable > 100 liver & nodal metastases). Tumor markers in thousands. Picked up MSI-High. In COMPLETE RESPONSE on #Immunotherapy. QOL⬆️after 1 dose‼️#CRCSM
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Day1️⃣Back from #ASCO22, my radiation ☢️ oncology colleague wants to know the MMR status before simulation on a patient with rectal cancer. @ASCO well done @AndreaCercek.👏🏾. ✅Will push for 💯 reflexive MMR testing 🔬 for all patients with colorectal cancer across 🇺🇸 and 🌍.
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IMBRAVE050. Adjuvant Atezo➕BEV. For hepatocellular cancer (HCC) #HPBCSM. @OncoAlert #ASCO23 . 78% 🆚 65% 12 month RFS rate. What do folks think? Good enough as an endpoint or wait till OS data?
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Just published @CCR_AACR. Is it a myth🐉that you can’t detect fusions on #ctDNA?. 👇🏾Presenting one of the largest datasets on #LiquidBiopsies & Fusion🖇️detection. 53,842 patients.1️⃣4️⃣% had a pathogenic rearrangement detected.Shedding💦matters. @OncoAlert.
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#GI23 @ASCO. What’s another upper GI biomarker to add to the list? Stay tuned:.👇🏾.💡All IHC🔬based.1️⃣HER2.2️⃣MMR.3️⃣CPS-PDL1.4️⃣FGFR2.5️⃣ #CLAUDIN 18.2 (CLDN18.2). 2 press releases recently:.@KlempnerSam @mdmanishshah @OncoAlert.“🔦SPOTLIGHT: FOLFOX +/- Zolbe.🕯️GLOW: CAPOX +/- Zolbe”
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We got a podium presentation with an invited discussant at #ESMOGI24.🙌🏾. 💡Will be presenting the full set of results and long term follow up on our #NESTTrial🪺. 🗓️Fri, 28.06.2024.🕟16:30 - 17:45.📍Room 1.✈️Munich, Germany🇩🇪 @myESMO . #CRCSM @OncoAlert.
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🆕 🗞️ @Annals_Oncology. The largest series to date on POL-E or POLD1 (proofreading-deficient) metastatic #ColorectalCancer and the use of #immunotherapy. Tumors➡️MSS but have a very high TMB (ultra-hyper-mutated - TMB > 100 Mut/Mb). @myESMO @OncoAlert .
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We have some incredible news.🗞️ .#NEST-2 🪺 BOT/BAL we are at our 12+ patients with MSS #ColorectalCancer within weeks!. Further expansion approved🙌🏾. 💡Cohorts:.🟢MSS Colon n=77.🔵➕a 🆕 MSS Rectal cohort n=30.🔴MSI-H n=15. 🏃♂️with this story! @OncoAlert.
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📍@ASCO GI23 is now even more special. I was part of a trial that led to an approval✅ @US_FDA.🙌🏾👏🏾🤗. ❓What do you need to know about #HER2🎯& studies in #colorectalcancer?. 👇🏾Here’s the money slide. @OncoAlert . From HERACLES to MOUNTAINEER ⛰️. 💡How to sequence? 💭 #CRCSM
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⚠️Important awareness message.🪧 .Saw this at #TimesSquare last night. Know the symptoms & seek appropriate care. Just last week, I saw 4 people from ages 26-39 in my🏥. All were stage-III or IV. Sometimes too late❗️. #CRCSM #ColorectalCancer📈.@preventcancer @OncoAlert #Cancer
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#ChalabiPlot💦📊 now in print @NEJM. Congratulations 🎉 @MyriamChalabi. 📌 With an editorial ✍🏾 by @AndreaCercek. 📌 What a good read 📖. Bookmarked.🔖 👏🏾 @OncoAlert #CRCSM. 💡Neoadjuvant paradigm shift.
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🙌🏾. 🗞️Our #ctDNA🩸🧬paper in the #JITCTop10!.MSI⬆️ #PancreasCancer. …median PFS/OS NOT REACHED.…among the 9 patients treated with ICI, 7/9 were alive at the time of data cut-off. 1 who went for surgery➡️pathCR! . #JITC #PANCSM @jitcancer Top🔟 @sitcancer @OncoAlert #OpenAccess
Countdown to 2023: #JITCTop10 - Detection of microsatellite instability-high (MSI-H) by liquid biopsy predicts robust and durable response to immunotherapy in patients with pancreatic cancer @pashtoonkasi @doctorC369
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This #GivingTuesday help us reach our goal 🙏🏽. We are building our🔬lab focusing on #research on #cancer💡using #liquidbiopsies🩸🧬#ctDNA. ➡️Donate.🗣Share ē family/friends.💡No amount is small. 📌UIOWA link to donate/Learn More👇🏾. #GivingTuesday2020
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Any oncologist who has ever stepped into a room with a patient with Cancer of Unknown Primary (CUP), or treats rare tumors 🦓 knows how important these👆🏾agnostic approvals are. Getting impossible to get access to💊 despite good 📝 . 🙌🏾Win for #PrecisionMedicine #PrecisionOncology
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Here’s a 🧵 #Tweetorial on #Fusions & other important rearrangements. Yes 🙌🏾✅, they can be detected on #LiquidBiopsies🩸🧬. Money slide:.Among 32,025 patients ē solid tumors, .we found pathogenic rearrangements in .3,565 (1️⃣1️⃣%) #LiquidBiopsies. #ctDNA. #ISLB2022 @OncoAlert 1/7
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#GI22 @ASCO #VisualAbstract.Day3️⃣Kickoff. Across tumor types, what is the most actionable marker?.✅#MicrosatelliteInstability dMMR/MSI⬆️. Our analysis of 3️⃣0️⃣,0️⃣0️⃣0️⃣ 🩸🧬 #LiquidBiopsies in GI Cancers. 🙏🏽 #ASCODailyNews 🗞Article:. @OncoAlert 🏃🏾♂️🛑poster.
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Today I got a message from one of my out of state patients who thanked me for persisting on asking for. RNA.➕.DNA. DNA didn’t show anything actionable. Guess what RNA showed?. #RET fusion 🧬🧬 . 💡Know your platforms. Know what you’re looking for. 🙌🏾.
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This #GivingTuesday help us reach our goal. We’ve already raised $10K🙏🏽 for building our 🔬lab focusing on #research on #cancer💡using #liquidbiopsies🩸🧬#ctDNA. ➡️Donate.🗣Share ē family/friends.💡No amount is small. #GivingTuesday2020. Link/Learn More📌.
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Let me shamelessly self promote the.“KASI”formula🔢 that I’ve found helpful in identifying the subsets of #colorectalcancer #CRCSM early:. 🧬BRAFV600E MSS 🆚 MSI-High 🆚 Others. Simple, rapid, & cheap👇🏾. ✅ CA19-9➗CEA ratio. 💡Small but novel finding.
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🤔What if the tumor is #MSI-High & has a #TRK-FUSION🛻 🧬❓. 🆕Published today🗞👇🏾. #ColorectalCancer❌response to #Immunotherapy (Pembro & IPI➕NIVO) .➡️brisk & CURATIVE response to NTRK⛔️Larotrectinib. #ctDNA #CRCSM #PrecisionMedicine @OncoAlert. Link:
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🆕drug approval!. #PrecisionMedicine. 🎯 #HER2-targeted bispecific antibody. ✅Zanidatamab-hrii for HER2➕(IHC 3+) Biliary Tract Cancer (BTC). Trials possible for ‘rare’ cancers like cholangiocarcinoma. More options for our patients. @OncoAlert @curecc.
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🛑 Stop removing the primary for the asymptomatic tumor in patients with metastatic unresectable colorectal cancer. #ASCO22 @OncoAlert #ThatstheTweet #CRCSM
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🆕Just published 🗞 . Want to learn more about #ctDNA & some of the challenges beyond the assay🧪?. See our letter @JCOPO_ASCO with @skopetz. The dilemma of false➖🆚 false➕. Shedding from metastatic sites💦.A lot to learn. 🙌🏾@OncoAlert 🙏🏽@DrawImpacts .
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#ClinicalTrials.✅#CIRCULATE🇺🇸 now open at @WeillCornell!🙌🏾. #ctDNA🩸directed chemo for patients with stage-III cancer. Also stage-II #ctDNA➕👇🏾. #LiquidBiopsies are revolutionizing cancer care. With Galaxy🌌/Dynamic-II📚 ➡️perfect time for this study. #TumorInformed🔬🧬 #CRCSM
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🗞️Just Published. #ASCODailyNews.🔦 highlighting our work on:. #ctDNA🩸🧬 kinetics 📈📉. t1/2 few hours/days. ➡️utility in this being a powerful tool that could be utilized in adaptive #clinicaltrials & beyond. @OncoAlert more to come @ASCO #GI23. 📰Link.
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