James Olzmann
@OlzmannLab
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Professor of Molecular Therapeutics and Metabolic Biology at UC Berkeley; Departments of Molecular & Cell Biology and Nutritional Sciences & Toxicology
Berkeley, California. USA.
Joined August 2018
Excited to share our new preprint! Exceptional work by postdoc @MikeLange identifies the first #LipidDroplet lipid quality control pathway! Droplet-localized FSP1 safeguards stored neutral lipids, blocking their peroxidation & #ferroptosis induction.🤩
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Thrilled to have been promoted to full professor @UCBerkeley! Thank you to all the members of my lab (past and present), my family, and my colleagues at UC Berkeley and beyond. Shout out to @DanNomura @RobertoZoncu @RapeLab @SJD956. What a journey! Very thankful. ☺️❤️
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Not sure who built this glorious throne, but I’m impressed. 😮 Seen in Li Ka Shing Center @UCBerkeley (Barker hall in background).
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Postdoc position available! Please RT! We are a diverse group of scientists @UCBerkeley interested in the cell biology of lipid homeostasis, ferroptosis, lipid droplets, cancer metabolism, lipotoxicity, ubiquitin, proteome remodeling and more! Apply here:
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Excited to see our paper online @ZhipengLi2718! We identify LRP8 as a ferroptosis resistance factor in cancer, revealing rewiring of selenium metabolism and ribosome stalling/collisions during GPX4 translation as ferroptosis vulnerabilities. Tweetorial! 1/
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Excited to launch @CRISPRlipid– A community-driven resource enabling exploration and comparison of functional genomic screens related to lipid / membrane biology. Terrific collaboration! @Mel_Roberts @MartinUCSF @mike_nalls @FarazFaghri @actuallyHadi
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Always been jealous that you receive a sword along with your PhD in Finland. Sooo… new Olzmann lab tradition!!! Congrats to the newest alumna from the lab, Dr. Melissa Roberts @Mel__Roberts!! We miss you already!! ❤️
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I'm in love with these videos of #LipidDroplets rocketing around the cell ahead of MirA-stimulated assembly of actin comet tails. Very cool @biorxivpreprint from @MattWelchLab!
Check out this exciting new story by postdoc Norbert "Bisco" Hill just out in @biorxivpreprint, featuring rocketing Mycobacterium marinum bacteria and lipid droplets! "A mycobacterial glycine-rich protein governs actin-based motility"
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Absolutely thrilled, honored, and humbled to receive the ASCB Günter Blobel Early Career Award. Thank you! It is a privilege to be a part of the @ASCBiology community and to work together to advance cell biology and DEI in STEM. #ASCBMAC.
Congrats @OlzmannLab for receiving the Günter Blobel Early Career Award!!!! Well-deserved!! | ASCB
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Super excited to be moving into our new lab space next week! Just across the courtyard @UCBerkeley. Onward to the next chapter of the Olzmann lab! 🙂
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So happy to see our review online in @NatureCellBio - “Lipid droplets and cellular lipid flux” - lead by super star grad student @alymathiowetz! Droplet biogenesis/ turnover, contacts and lipid transfer, roles in lipotoxicity / cell death, and more! 🎉
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Yay! Our paper is out! A tour de force from superstar grad student @Mel__Roberts! CRISPR screens in multiple genome-edited reporter cell lines identify mechanisms of PLIN2 and lipid droplet regulation. Brief tweetorial below 👇! 1/12
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Wow! I just realized that today is our lab’s 10 year anniversary. How time flies! So lucky and privileged to work with an amazing group of scientists and colleagues. Proud of what we have accomplished and excited to see what the next 10 years will bring. Onward! 🎉 🥰 🥳
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Clear my schedule. I need to like every single Doudna / Charpentier Nobel Prize tweet. every. single. one. 🥳 #CRISPR.
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Other parents: 😍.Me: Ok, pay attention class. For the last time, lipid droplets are ER-derived neutral lipid storage organelles that functions as cellular hubs of lipid metabolism… .(mine is on the far right 😊)
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Happy that my joint appointment in the Department of Molecular and Cell Biology (@berkeleyMCB) has been officially approved. Yay! Excited to be joining this community of amazing scientists and colleagues.
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Thrilled to see our new review "The Cell Biology of Ferroptosis" w/ Scott Dixon (@SJD956) is online! We discuss the execution and regulation of ferroptosis, provide an organelle-centric view of the process, and highlight the many open questions. 🎉
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So excited to see our paper out describing new FSP1 inhibitors that sensitize cancer cells to #ferroptosis!! This study was spearheaded by an amazing grad student @JosephH51211253 and a terrific ongoing collaboration w/ @SJD956 & Julia Schaletzky. 🥰 🎉
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So excited about our new preprint! In a tour de force, super star grad student @Mel__Roberts used genome-edited reporter cells and a series of CRISPR screens to identify mechanisms of PLIN2 and #LipidDroplet regulation under different metabolic states. 🤩
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Awesome to see our recent paper highlighted on the cover of Nature Chemical Biology @nchembio! Amazing artwork from Maayan Harel @maayanvisuals! Thank you, Maayan! "Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability"
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Moving trucks taking our -80 freezers to @ucsf because our @UCBerkeley building doesn’t have backup power and PG&E is shutting off the power (up to 5 days?!). Incredibly disruptive to our research.😔 Big shoutout to @RobertoZoncu for letting us put our cells in his incubators!
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Excited to share our preprint describing the identification of several new FSP1 inhibitors that sensitize cancer cells to ferroptosis!! 🎉 This study was spearheaded by grad student @JosephH51211253 and was a terrific collaboration with Julia Schaletzky.
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New preprint w/ @apsarruda! Tour de force from grad student extraordinaire @alymathiowetz! >20 CRISPR screens enabled the discovery of a key role for CLCC1 in hepatic neutral lipid flux and nuclear pore complex assembly. Many surprises! #LipidDroplets 1/3
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My award essay is now online in @MBoCjournal for the 2020 @ASCBiology Günter Blobel Early Career Award. An honor to receive this award and to write this essay on “Diversity through equity and inclusion: The responsibility belongs to all of us”. #ASCBMAC
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Be your organelle!! Dreams do come true. I have the best lab! 🥰😂 do I look fat in this pic? #LipidDroplets
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Exciting new work in @ScienceMagazine identifies a role for #LipidDroplets in innate immunity. Lipid droplets act as platforms for the organization of immune proteins and modulate host cell metabolism to combat pathogens.
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Excited to share this preprint from an amazing postdoc in our lab @ZhipengLi2718! Low selenium levels in LRP8 KO sensitizes cancer cells to #ferroptosis due to an increase in ribosome stalling, ribosome collisions, and early GPX4 translation termination.
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It's official, my promotion to Associate Professor WITH TENURE has been approved. WOO!! I am so grateful for the support from my mentors, family, colleagues @UCBerkeley, and amazing lab members. What a journey! Excited to pass this hurdle and looking forward to the next chapter.
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Our @STARProtocols is now live! We describe a step-by-step "Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics in cultured human cells"
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We just deposited data from 12x CRISPR screens related to lipid droplets in #CRISPRlipid These include genome-wide and focused screens under different metabolic conditions. @alymathiowetz @CRISPRlipid.Details in recent preprint:
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Please RT. Amazing opportunity coming up for postdocs on the job market. New @UCBerkeley @Stanford @UCSF joint symposium to highlight the work of exceptional scientists with a track record of enhancing DEI in STEM. Apps due Sept 10!
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Thrilled to receive this Bakar Fellows Spark award to support our translational efforts targeting #ferroptosis for human health. Thank you for supporting our research @BakarFellows!!
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Heartwarming story: My aunt has been struggling on dialysis after kidney failure. A college friend she hasn't seen in years volunteered to donate a kidney. Transplant happened last week and everyone is doing great! Some amazing people out there. Faith in humanity restored. 🥰.
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What a nice surprise to see our review on the “Cell Biology of #Ferroptosis” (w/@SJD956) featured on the cover of the current issue of @NatRevMCB. ☺️ .
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Excited to see our paper online in @Nature – “The CoQ oxidoreductase FSP1 acts in parallel to GPX4 to inhibit ferroptosis”. @UCBerkeley @NatureAtCal
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An honor to receive this year’s Emory distinguished alumni award. What a fun visit! Wonderful to see so many friends & colleagues and reminisce about my time as a grad student at @EmoryUniversity (@neurophd_emory 2002-2007). Thank you! 🥹 🙏
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Interested in performing a pooled #CRISPR screen? .Check out our new @STARProtocols w/ detailed step-by-step methods, from design to screening to analysis. Terrific work from @ZhipengLi2718 @Mel__Roberts @alymathiowetz @DavidMorgens
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Please RT to help reach a diverse audience. Assistant Professor position @UCBerkeley in metabolic biology (broadly defined). Looking for excellence in research AND diversity, equity, and inclusion efforts. Please apply and come join us!
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It's official! Excited to be co-organizing the @FASEBorg conference on “Ferroptosis, Oxidative Stress, and Lipid Metabolism: From Mechanisms to Therapy” w/ Scott Dixon @SJD956 !! Next summer July 27-31 2025! Save the date. More details coming soon. 😀 #Ferroptosis #LipidTime
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Postdoc position! Please RT. We are a diverse group of scientists @UCBerkeley leveraging interdisciplinary strategies to uncover fundamental principles that govern organelle and lipid homeostasis. #lipiddroplets #ferroptosis #ubiquitin #ERliterature
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Enjoying walking across the @UCBerkeley campus on a beautiful spring day. Nice to have some sunshine. So much rain lately! 🌞
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So excited for my postdoc @ZhipengLi2718, who has accepted an Assistant Professor position in the BMB Dept at the University of Florida! They are lucky to have you!! We are all going to miss you @berkeleyMCB and we can't wait to see all that you accomplish in your lab! 🤩🎉
I'm thrilled to share that I'll be starting as an assistant professor at the University of Florida, BMB Dept! @UFMedicine. I owe a huge debt of gratitude to my mentor James @OlzmannLab for his invaluable guidance and unwavering support throughout my training and job search!.
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Excited to announce that Mike Henne (@HenneLab) will co-organize the next @FASEBorg Lipid Droplet conference with me in 2024! Looking forward to working with you, Mike! #LDSRC24 is going to be AWESOME! 🎉🤩 #LipidDroplets #LipidTime
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It was a privilege to be the Guest Editor for this @J_Cell_Sci Special Issue on the Cell Biology of Lipids. Terrific reviews, articles, interviews, and more. Thank you to the authors for their contributions and to the @J_Cell_Sci staff! 👏🎉🤩 #lipidtime .
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Happy to see this review, written with an amazing graduate student Melissa Roberts (@Mel__Roberts), out in @AnnualReviews. We explore emerging intersections of #lipiddroplet metabolism, proteome regulation, and protein quality control.
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I love the @UCBerkeley campus. Friend took these photos with a drone last weekend (so cool, need to get one of those). @Cal
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Happy belated 10 year birthday to #Ferroptosis!! @SJD956 @bstockwell published their seminal ferroptosis paper in @CellCellPress on May 25 2012. 🎂🎉🥳 Interesting to reflect on how the field has progressed and what the major questions are moving forward.
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Excited our review is online! w/ @ZhipengLi2718 @MikeLangePhD @SJD956! “Lipid Quality Control and Ferroptosis: From Concept to Mechanism” We introduce the concept of lipid quality control using #ferroptosis as an illustrative example. Tweetorial! 1/8.
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New reading material arrived for the members of my lab today. Can't wait to start reading this @doudna_lab. 🙂 @berkeleyMCB @UCBerkeley @Cal
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Wow! Looking forward to digging into this one. “Identification of an alternative triglyceride biosynthesis pathway” 🤯🤩.
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Thrilled to join the MBoC editorial board as an Associate Editor. Send your manuscripts for a fair / rapid review and support @ASCBiology! #lipiddroplets #lipid #ERliterature #metabolism #ferroptosis #lipotoxicity #ERAD #proteinqualitycontrol #ubiquitin #organelle #membrane.
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An honor to receive a Presidential Early Career Award for Scientists and Engineers. It is such a privilege to be a scientist, and to have the opportunity to work toward understanding fundamental principles of biology and improving human health. #PECASE
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Excited to be elected as the co-organizer (w/ @BobFarese) of the 2022 @FASEBorg Lipid Droplet Conference. Thank you! Keep us posted on your coolest #lipiddroplet research and discoveries. Looking forward to a terrific meeting in 2022! #LDSRC22.
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One of my favorite benches on the @UCBerkeley campus. Beautiful day to sit and work outside. 🙂 @Cal
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Quick selfie with science hero @CarolynBertozzi !! 🤩 Such an inspiring commencement speaker! Congrats to all the @berkeleyMCB graduates! 🎉
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Excellent review on #LipidDroplet lipolysis out from @MartinaS_lab and Zechner and colleagues. 👏 "Lipolysis: cellular mechanisms for lipid mobilization from fat stores"
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Such a privilege to work with this amazing group of scientists! Fun times at our lab holiday party. Wishing everyone a wonderful holiday season!😊❤️🤩
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Daughter (3.5 yr/old) when I tucked her in for bed - “I love you like 10 pounds of ice cream!” 🥰 🍦 . Dad win of the week. :).
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I know I’ve said it before, but I’m pretty sure I have the best lab! Thank you for the surprise celebration and collage of memories! 🥰🥹
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Tenure track Assistant Professor faculty position open at @UCBerkeley in nutrient signaling and metabolic biology (broadly defined). Metabolite sensing, regulation, signaling, flux, disease, etc. Please repost and help me get the word out. 😀.
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Save the date! @FASEBorg Lipid Droplet Meeting June 26-30 2022! It's going to be a terrific meeting exploring a range of topics – from #LipidDroplet biogenesis to physiology and disease. Short talks selected from submitted abstracts. #LDSRC22 @BobFarese
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Honored to receive a Miller Institute Professorship award @UCB_MillerInst. Looking forward to being part of this interdisciplinary community and to exploring new research directions. Congrats to @adernburg and other awardees!
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Happy to contribute, along with several fantastic scientists, to this Voices article in the @MolecularCell focus issue on metabolism. We discuss exciting advances, emerging topics, unanswered questions, and disruptive technologies in metabolism research.
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Everything you've ever wanted to know about #Ferroptosis in Health and Disease! Massive review from many in the field. Happy to have contributed and huge thank you for the leadership from Carsten Berndt / Marcus Conrad @Conrad_Lab. 🙂 .
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So fun to celebrate the team’s recent FSP1 inhibitor paper out last week in @CellChemBiol. Led by exceptional grad student, Joe Hendricks @JosephH51211253. Such a joy and privilege to work with all the amazing members of my lab. 🥰
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Excited to join the @MBoCjournal editorial board as an Associate Editor. Publish your work & support @ASCBiology! If assigned to me, I'll work hard to provide a rapid & fair review. #MBoC #lipiddroplets #lipotoxicity #organelle #metabolism #qualitycontrol
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Mark your calendars! The 1st FASEB #Ferroptosis conference, July 27-31 2025! We just posted our preliminary agenda! Spectacular line up and lots of space for short talks / late breaking speakers. Help us get the word out & come join us in 2025! @FASEBorg .
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Wow!! Beautiful double rainbow over San Francisco Bay Area this morning! 🥰🤩
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Please RT and help us get the word out. Scott Dixon @sjd956 and I are co-organizing the first @FASEBorg #Ferroptosis conference this summer! Awesome line up of speakers and room for additional short talks! Save the date & come join us July 27 - 31, 2025! 🤩
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Found while cleaning up the lab. Drawing on an envelope from a former student. Saving this one. 🥰
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Excited to be en route to the #EMBOLipidDroplet conference in Spain!! See you soon droplet friends!! 😊
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What a great lab retreat on the Northern California coast. Some beach, surfing, good food, and the best group of scientists I could imagine! So fortunate and privileged to work with this group! 🥰 #NorCal
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After being closed for 98 long days, our lab at @UCBerkeley is finally open again! (with reduced personnel density / capacity and extensive safety measures in place) Yay! Let's make some discoveries! #lipiddroplets #ferroptosis #ERliterature #lipotoxicity.
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4 James lunch! Jameseseses. 😂 awesome to be able to get together for lunch with these amazing @berkeleyMCB colleagues. @jhdcate @TheHurleyLab @jamesknunez ! 😊🤩
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Huge congratulations to Dr. Alyssa Mathiowetz @alymathiowetz and Dr. Joseph Hendricks @JosephH51211253, two absolutely amazing graduate students!! So privileged to have been a part of their journey and excited for what the future holds. 🎉 🤩 @UCBerkeley
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Olzmann lab summer pool party! Privileged to work with such an amazing group of scientists! ☀️☺️
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Fun lab lunch outing. So appreciative of this amazing group of scientists that I have the privilege to work with! ❤️☺️
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Mark your calendars! The @FASEBorg Lipid Droplet Conference will be next summer July 21-25 2024 in St Paul MN at the Intercontinental Hotel! Beautiful venue and an amazing lineup of speakers! Co-organizing with @HenneLab. Website with more info coming soon. #LDSRC24 #LipidDroplet
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New review from Lauren Pope (@pope_lauren_) & Scott Dixon (@SJD956) on the regulation of ferroptosis by lipid metabolism! 🤩🎉
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New Nobel Laureate parking spot being installed on @UCBerkeley campus. @doudna_lab parking spot? 🙂😊
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Please RT. Application deadline for the Stanford.Berkeley.UCSF Next Generation Faculty Symposium is coming up soon (Aug 9 2021)! Symposium highlights the work of exceptional scientists with excellence in both research and DEI. Fantastic opportunity!!
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This is so cool!! METALIC (Mass tagging-Enabled TrAcking of Lipids In Cells), a method to track interorganelle lipid flux inside cells, is used to study ERMES and Vps13 lipid transport function. Amazing @ATJohnPeter @BenoitKornmann! 🤩🔥👏
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Thrilled to be the guest editor for the @J_Cell_Sci.special issue on the Cell Biology of Lipids! Send your science! I will work to provide a rapid, fair, and constructive review process. Read more about the topic / issue in the editorial from @DrMichaelWay.
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Great to see that our FSP1 inhibitor (FSEN1) is already available from @CaymanChemical. Hope that this new inhibitor will be a useful tool for the #ferroptosis field! See our bioRxiv preprint for more info - (pub coming soon!).
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