Nekisa Zakeri
@nekisa_zakeri
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Clinician Scientist & Consultant Hepatologist. Wellcome Early Career Investigator. Interests in liver cancer, gamma delta T-cells. Y-ILCA & HCC UK Committee.
Birmingham/London UK
Joined October 2015
Now official! Really delighted to receive a Wellcome Early Career Award for 5yrs of gamma delta T cell research in HCC! 🎉Hugely grateful to @wellcometrust, amazing collaborators, support from @unibirm_MDS & look forward to continuing @Bham_HPB_LTx @BirminghamLiver @HCC_HUNTER 🙌
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Really pleased to share our paper published today - comparing radiology vs. explant histology following bridging SABR for HCC. A small cohort but highlights the need for radiological criteria to more accurately reflect SABR treatment response in HCC 👉 https://t.co/i7Z28ogRhY
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This is a Studio not to miss!!!! I’ll be joined by the incredible @DavidPatch1 and very wise Wim Laleman to discuss all things to do with the endoscopic and non-endoscopic management of acute variceal bleeding. @BavenoCoop @BSGTrainees @BASLedu @EASLedu @BoppPtrial @AvbReact
📺 Next on #EASLStudio: Endoscopic Management of Variceal Bleeding: Outdated or Evolving Beyond Tradition? Discover cutting-edge approaches to managing bleeding varices, the role of interventional radiology, and insights on EUS-guided portal pressure assessment. Don't miss it:
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Development of fully human T cell receptor–mimetic antibodies enabled the generation of CAR T therapies against intracellular tumor-specific antigens https://t.co/KVeCtxSOee
@ScienceTM
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Connecting art and science! An inspired collaboration from Royal Academy of Dance and @TheCrick @HaydayLab portraying vaccination through dance, a preview from @royalsociety. 🌟A good reminder to be creative in our approach to science communication🧬@RADheadquarters
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Thrilled to share new work led by @JieYang437 in the lab published today in @Nature. We find that Aspirin prevents metastasis by releasing T cells from immune suppression by platelet TXA2. @Cambridge_Uni @CRUKCamCentre
https://t.co/dO2v0GWKAn
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Happy International Women’s Day! We’re celebrating women who have changed the world. Here are all of the amazing women who have received the #NobelPrize and their remarkable achievements at the time of the award. Tell us about the women who inspire you the most - and why
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The authors of today’s #readoftheweek📚 developed an automated system using CD8-stained whole-slide images to assess immune infiltration (ATLS-8) in patients with #HCC. Learn why this system could be a promising tool for advancing clinical immune microenvironment assessment and
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#GUTImage from the paper by Link et al "ECM1 attenuates hepatic fibrosis by interfering with mediators of latent TGF-β1 activation" via https://t.co/bWOqGx922y
@LiebeRoman #LiverFibrosis
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To celebrate International Day of Women and Girls in Science we asked @ginasue, @channelswimsue and @HelenMargetts what advice they’d give to someone considering a career in STEM 👇 #WomenInScience
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We're celebrating the International Day of Women and Girls in Science! Let's look back on the life of Marie Skłodowska Curie: a Nobel Prize laureate who dedicated her life to science and became one of the world's greatest scientists. #WomenInScience #NobelPrize
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A very innovative approach to cancer: engineering fat cells to convert to beige fat to starve tumors, outcompeting 5 types of cancer in experimental models https://t.co/KZJPD6fvac
@NatureBiotech @NadavAhituv @UCSFMedicine
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🚨 Out now in @NatureComms our new piece! "A proof-of-concept study in small and large animal models for coupling #liver
#normothermic #machine perfusion with mesenchymal stromal cell bioreactors" 💡Can we reduce the effects of ischemia/reperfusion ?! https://t.co/tvyJ2yMKlk
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Very excited to present our phase 2 RCT on “ autologous macrophage therapy for liver cirrhosis” published today in @NatureMedicine
https://t.co/uetgfK8i8p ⚡️I've summarised some of the key aspects of the trial 🧵
nature.com
Nature Medicine - Results from the phase 2 MATCH01 clinical trial of autologous monocyte-derived macrophage therapy for liver cirrhosis revealed no liver-related severe adverse events or deaths in...
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NEW PAPER ALERT 🚨 out now in @JHepatology, our groups review on cellular interactions in self-directed immune liver diseases. We discuss the mechanisms of immune cell recruitment, crosstalk and activity associated with immune-directed liver damage. https://t.co/BAJrbXM59e
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OS benefit with liver Tx for HCC based on tumor burden at listing @HepCommJournal
https://t.co/WfM7KaxbtT 🔎36,634 LT pts 👉High-TBS pts: high waitlist dropout, but only marginally lower post-Tx OS > greater benefit 🧐we need to rethink organ allocation for HCC @myESMO @EASLedu
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Liver Transplantation for HCC: An Expanding Cornerstone of Care in the Era of Immunotherapy @JCO_ASCO
https://t.co/5DCGJkct4H 👉We have entered a new area in the management of HCC 👉Cure & downstaging to LTx becomes feasible 😅Our thoughts... @myESMO @EASLedu @ILCAnews
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🌟 What’s it about? Biliary abnormalities in autoimmune hepatitis (AIH) and interface hepatitis in primary biliary cholangitis (PBC) can often be misinterpreted, leading to therapeutic mistakes that negatively impact patients.
📝 Hot off the press! Leveraging AI to improve diagnostic accuracy in #AIH. A huge leap in reducing diagnostic error & improving patient care #compath Collaborative work with @jnkath, led by @AlessioGerussi @unimib @EASLedu @ESOTtransplant
https://t.co/eh8uI0l9aE
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As part of the @UK_AHA we were delighted to support this story raising awareness of alcohol harm and calling for the Government to take action. Thank you so much to Emma, one of our supporters, for bravely sharing your story.
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