Natalia Szulc
@n_szulc
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Scientist specializing in rare diseases, owner of LumiRare. We provide advanced scientific insights and personalized support using the latest research and tech.
Joined November 2021
Check out our new paper on a rare disease 🦓 related to MAPK1 mutation and our insights in its pathogenicity based on molecular dynamics 👩💻, fibroblasts 🧫 & C. elegans 🪱 studies.
We have identified a novel MAPK1 variant linked to a psychiatric disorder with early-onset dementia and demonstrated its role in age-dependent neurodegeneration. Thanks to all collaborators involved! #Proteostasis #C_elegans #genetics #neurodegeneration
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Thrilled to share that DEGRADATOR—our computer game exploring protein degradation and PROTCAs—is now published as a paper! 🎉🥳 🎮 Play at:
Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @ACSPublications! Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
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🎉 Thrilled to share that @wojtek_pokrzywa’s lab secured a 4-year OPUS grant from @NCN_PL! 🥳 Ranked 1st in the NZ3 panel, we’ll explore diseases tied to protein degradation defects and develop new therapeutic strategies. Stay tuned for updates and recruitment info! 🧬🔬💊
📢Over PLN 6 million from the @NCN_PL for basic research at IIMCB! Dr. @wojtek_pokrzywa , prof. @MatthiasBochtl1 and doctoral researcher Aleksandra Uryga are among the recipients of OPUS and PRELUDIUM grants. Congratulations👏 📰read the news:
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🎊Thrilled to receive, with @wojtek_pokrzywa & Prof. R. Płoski, a Polish Academy of Sciences @PAN_akademia distinction for discovering new proteostasis mechanisms vital to organism function & therapies. 🧬🔬🪱 Also celebrating team members: @Michal_R_Turek, A. Das & A. Dubey 👏
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Thrilled and honored that our DEGRADATOR - A Protein Degradation Game was recognized! 🎊 📣Huge kudos to the amazing team that brought it to life! 🙏🎆
DEGRADATOR game by Natalia Szulc @n_szulc won 3rd place at the International Educational Games Competition! 🏆 A great achievement proving that science can be fun and accessible!🎮🧬 👉Read the story: #Degradator #ScienceEducation #DegradatorGame
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New paper on CHIP ubiquitin ligase from our lab 🎉🪱🔬
Why does HSP70 inhibit CHIP E3 ubiquitin ligase activity? Using C. elegans, we developed a tool showing that HSP70 limits CHIP under stress to prevent excessive turnover of its substrates, preserving germline function. @jbiolchem
#Proteostasis #C_elegans
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Thrilled by the amazing reception of the DEGRADATOR game! 🕹️👾 Be sure to check it out at
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Honored to present my PhD research at #EMBOubiquitin24 in beautiful Cavtat! 🌊☀️🇭🇷 & grateful for the opportunity to hear about all the fascinating science from the amazing ubiquitin community! 🔬✨
Very interesting talk by @n_szulc at #EMBOubiquitin24 who described us lysine deserts and cullin-RING ligase receptors
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Can't believe it's been two years already! So excited to be back in Cavtat 🇭🇷 #EMBOubiquitin24
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In 2 years, Gosia & Piotr Kośla united scientists to explore potential therapies for PACS2, culminating in a conference on par with the best ones + overflowing with hope & inspiration. You are shaping the future of communication and science-driven approaches for all patients! 2/2
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RT @IIMCB_Poland: Our project #Degradator by @n_szulc from @wojtek_pokrzywa Lab of Protein Metabolism has been highlighted among the featur…
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Excerpt from LumiRare's report on an undescribed potassium channel mutation. Our personalized #RareDisease analyses explore cellular pathways, model organism data and potential therapies. We also connect patients with top labs to drive new experiments. See
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🔬 + 🪱 + 💡 = new C. elegans optogenetic tool co-developed by our lab 🧨
🔬 Pleased my lab contributed to this research in @NatureComms. We developed the optogenetic OptIMMuS methodology in C. elegans to study muscle proteostasis under mechanical stress, identifying the regulatory TRIM E3 ligase NHL-1. #Proteostasis #C_elegans
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Of worms 🪱, cold ❄️, FUdR 💊 and proteostasis ⚙️ Check out our new paper to learn how FUdR can bolster proteostasis independently of reproduction pathways and common stress response mechanisms, by activating a distinct detox pathway instead… 🫨🫨
Our new study shows how floxuridine boosts the UPS under proteasome dysfunction. • Independent of major regulators & germline signaling. • Activates a unique detox pathway. • Aids cold survival and lifespan. #MolecularBiology #Proteostasis #Celegans
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With @wojtek_pokrzywa we started LumiRare, specializing in scientific analyses for #raredisease patients. We provide, i.e., comprehensive reviews of the latest gene mutation knowledge, supporting patients & carers. Discover how we can help your family. ➡️
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If you missed this event but wonder what VHL, SOCS1, and lysine deserts have in common, and can the lysine-less variants of these proteins still be ubiquitinated, 👉 check our published story:
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