Manuel Irimia
@mirimiam
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ICREA Evolutionary Biologist working on transcriptomics of development and evolution at @UPFbiomed and @CRGenomica. Coordinator of the @EvoMG_Bcn Joint Program.
Barcelona, Spain
Joined April 2011
New release of annotations in @VastDB (v11). With this release we cover all the previous studies experimentally investigating the functions of AS events we were aware of, with a total of 5542 entries (EventID-PubmedID pairs). @CRGenomica
We have released a new batch of functional annotations (v11): 600 entries from previous publications investigating the function of AS events. This makes a total of 3637 entries directly from publications, 397 from CRISPR screens and 1511 from experimentally validated ELMs.
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RT @inespatop: This sounds like a dream!! Barcelona and Berlin with amazing scientists and great people. Having worked with both groups I w…
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The job call is officially open. If you're interested, please apply through this link ASAP! 😃 Please RT! 🙏
🚨🚨🚨 If you're a bioinformatician who loves: 🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing 🚀 Collaborating and travelling Apply to work with us at the spectacular @BIMSB_MDC in Berlin + @UPFbiomed-@CRGenomica in Barcelona. Qs: Please RT!🙏
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RT @saez_cristina: Pot Darwin ajudar-nos a entendre el càncer, la infertilitat o les al·lèrgies? El primer programa de genòmica mèdica evol…
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RT @CrumpLab: The outer ear is a mammalian innovation but where did it come from? In our study in @Nature, @MathiThiru95 and colleagues fin…
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RT @ArnauSebe: Monod Conference "Origin of metazoans": fossils, genomes, cell biology, gene regulation, development, and more. Join us in…
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RT @ArnauSebe: One week left to apply! Join our team to explore the diversity chromatin regulation mechanisms across eukaryotes or to study…
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RT @UPFbiomed: 📢 We're hiring! We are looking for two early career candidates to join #MELISupf as Junior Group Leaders in Computationa…
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RT @mirimiam: 🚨🚨🚨 If you're a bioinformatician who loves: 🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing 🚀 Collaborating and tra…
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RT @XRBustelo: ✅Last paper of 2️⃣0️⃣2️⃣4️⃣, a great colaboration with @mirimiam of @CRGenomica where the role of micoexons in VAV2 and…
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@Ella_Maru @eLife @CRGenomica @UPFbiomed Thanks! They could be, yes. See this paper by @RNA_Ken for instance:
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@sepeap94 @FedeMantica @doctor_calvo @tahnee_mac @jordifernalbert @XRBustelo @dePolaviejaLab @ERC_Research And here’s Laura’s handle @lau_lbl 🤦♂️🤦♂️🤦♂️ congrats!! 🤗
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We also implemented a new method for primary neuronal culture and neurite length quantification from FACSorted HuC+ neurons. With this method we also identified microexons whose deletion leads to decreased (vav2) or increased (evi5b, itsn1) neurite lengths. 7/9
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In contrast to the strong phenotypes observed for their master regulator srrm3, most microexon mutants showed no phenotypes for most tests, with a few notable exceptions. E.g., vti1 and kif1b KOs showed social defects, yet far from those of the srrm3 mutant (blind) fish. 6/9
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We phenotypically characterized these microexon KO lines, along with those for srrm3 and srrm4, across multiple organization levels, including axon guidance, neurite growth, larval and juvenile locomotion, larval sensory responses, and social behavior in juveniles. 5/9
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To tackle this major open question, common to other tissue-specific splicing regulators, we generated CRISPR-Cas9 deletion mutants in zebrafish for 18 conserved neural-specific microexons regulated by srrm3/4, as well for srrm3 and srrm4. 4/9
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