Miguel V. Almeida
@migueldvalmeida
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🇪🇺🇵🇹 postdoc @ericmiskalab @CamBiochem @GurdonInstitute | interested in #transposons #smallrnas #evolution #epigenetics #telomeres | PhD @KettingLab
Cambridge, UK
Joined September 2016
🚨New preprint alert!!🚨 I am delighted to share my first postdoc research paper on the interaction between transposable elements (TEs) and piRNAs in African cichlid fishes 🐠🐠 Link here: Find the highlights in 🧵
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Our first deep dive into TEs and piRNAs in African cichlids is finally published!
🚨New preprint alert!!🚨 I am delighted to share my first postdoc research paper on the interaction between transposable elements (TEs) and piRNAs in African cichlid fishes 🐠🐠 Link here: Find the highlights in 🧵
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RT @Paula_milro: Our publication of the project from @alvarosomoza, Daniela Palacios and Jean-Jacques Toulmé labs is already available! Don…
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RT @SimoneImmler: We had a great end to 2024 publishing: The Zebrafish Sperm Proteome We described >5400 sperm…
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RT @AlexBoRNA: Interested in joining our growing interdisciplinary team studying viruses, RNA, and condensates? Looking for a postdoctoral…
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@AleksSzczurek @GurdonInstitute @CamBiochem @ericmiskalab @dralexdallaire @Jon_LP @XIAODANLIU3 @GuiomarPedro Thank Aleks! 😄
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RT @dralexdallaire: A nematode gene family evolved by fusing 💥 with a transposon! This is such a cool story, congratulations @migueldvalmei…
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In the last ~24h there have been some issues with our preprint's page. These issues do not yet seem to be fully resolved. The page may still show the wrong Cannabidiol abstract, but you can find the correct abstract in the pdf of the manuscript.
Just in case anyone is still here, check our latest preprint, right on time before the holiday season. We explored how transposable elements (TEs) diversify eukaryotic proteomes and found a cool case in nematode F-box genes. Short 🧵 with highlights.
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@wayomayo @kazuigarashi Thank you Wayo. I contacted BioRxiv and they are working to solve this.
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RT @wayomayo: @kazuigarashi @migueldvalmeida bioRxiv is currently having issues, and somehow a random abstract is seemingly loaded at the m…
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Deletion of the helitrons recapitulates the phenotype of fbxa-215 null mutants. Overall, this demonstrates multi-layered TE-driven innovation, combining functional diversification through the acquisition of a TE-derived domain and regulatory integration via unrelated TEs.
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How did we get to roles in thermotolerance? Directly upstream of the locus of fbxa-215, the most highly expressed A2 gene, we found Helitron TEs, which are known to spread across the genus binding sites for HSF-1, a conserved transcription factor that responds to heat-stress.
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These proteins have a Tc1/Mariner-derived Helix-turn-helix (HTH) domain and an F-box domain. After some phylogenomics detective work, we figured out that the HTH domain was captured by an F-box gene and subsequently expanded, creating a novel class of F-box genes, the A2 family.
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We had a look at the largest sets of proteins with the same co-occurring domains and their phylogenetic distribution. One set of around 500 proteins caught our eye because these are restricted to one of our favourite nematode genus: Caenorhabditis.
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We used publicly available protein data to screen 10 million eukaryotic proteins and found 12,803 proteins with domains that define multi-copy gene families together with TE domains. How to find interesting biology among all those hits?
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TEs often encode the protein machinery they need to mobilise from one locus to another. It is well established that these coding sequences can fuse to host genes, increasing protein diversity and potentially bringing about novel functions.
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How do novel proteins emerge? François Jacob compared Evolution to a tinkerer, with novelty arising as a result of rearrangement of available pieces. This can be applied to protein evolution, with novel proteins arising through the shuffling of different pre-existing domains.
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