UCSF ‘03, UCI Med ‘99. The Brain, Biochemistry & Cell Biology. LongCovid/LongCovidVaccinationSyndrome/PACVS. Tweets are my own & not medical advice. She/her
“So how long am I going to do this? Until indoor air is safe for all, until vaccines prevent transmission, until there’s a cure for Long Covid. Until I’m not risking my family’s future on a grocery run. …however immortal we feel, we r all just 1 infection away from a new life.”
Singapore is surging. We will have multiple “Singapores” here in the US. Their surge is higher than any they’ve had. 83% fully vax’d @ the time of this graph.
Does this look like u can’t surge if u have a significant amount of vax in your country or state? US is 57% fully vax’d.
@EmbryEthan
Everyone needs to document what their symptoms are like each time they r infected, if everything resolves or not & what symptoms maintain/worsens. The gaslighting will continue. We need to document in videos & in words, time& date stamped, what is happening.
The AY.23 (Delta sub-lineage) rose rapidly in Singapore during July and has almost totally displaced B.1.617.2 ("ancestral" Delta). Variants didn’t stop when we decided that ancestral Delta was “probably the last significant surge”. Let’s stop making this mistake.
@BQuilty
Strongly consider having all attendees complete their rapid test 1-2 hours before a gathering and have extras on hand for those who forgot BEFORE they come indoors (if possible). Just takes 15-20 minutes! Morning can have negative result but by evening, can be positive!
This is a coronavirus pandemic that can last decades to generations. It’s not a flu pandemic that lasts 3 waves. We only slow this down as fast as we can race against this significant foe. VAX, BOOST, MASK, UPDATE VAX, & hope for ANTIVIRAL COCKTAIL with limited side effects.
@EmbryEthan
Such a similar phenomenon occurs for people w/ multiple concussions. So many have been told that what they are suffering they made up or hyperbolized. The damage can’t be seen on the surface of the body & many do not want to believe that concussions can cause permanent damage.
Dr. Ugur Sahin, Founder of BioNTech
@VirusesImmunity
Virus is “just beginning” to escape immune responses. Other molecules may be involved in uptake of the virus & entry of virus. The spike should not be our only focus. Prepare for unexpected evolution.
Dr. Ugur Sahin has a warning for what may be to come in the battle against the Covid-19 virus.
"The virus is starting to escape immune responses," he says. "So we need to be prepared for also unexpected evolution."
Decreasing the ability of the brain is a bad idea for children and young adults with a whole life ahead of them. And to those primarily economy focused, caregivers will be pulled from their jobs to attend to the moderately and severely disabled. Get ready. It has already started.
“…a coronavirus epidemic swept East Asia some 20,000 years ago & was devastating enough to leave an evolutionary imprint (this means a lot of people died or could not reproduce) on the DNA of people alive today.” That’s a coronavirus epidemic that lasted decades or generations.
@DrSalandyinGA
How long protected?
“Although CDC considered symptomatic infection < 35 Ct-value with ≥ 45 days interval between two rRT-PCR tests as reinfection cases; Tang et al. identified reinfection cases within 19 days by different PANGO Lineage SARS-CoV-2.”
“The vaccines have worked to keep most of the population out of the hospital, w/ 98.4 percent of cases presenting mild or no symptoms. But the shots cannot protect against infection [& may not block Long Covid enough], especially when up against the Delta variant, Mr. Wong said.
But has it required them to increase mitigations again? YES. Long lines started forming at the emergency departments @ several hospitals. With cases doubling every 8-10 days, the government limited social gatherings to 2 people & told people once again they should work from home.
Summary & presentation markers for what is known about the NEW, VERY CONCERNING
#VARIANT
B.1.1.529 per South African Ministry of Health live streamed briefing today.
Still tremendous pressure on healthcare systems & potential for significant Long Covid which can be as impactful as deaths on a country. We have the “famine of corms effect” going on all over the world w/ multiple sectors & countries having trouble hiring despite many open jobs.
What say you? But is it impacting their healthcare services? YES. “Singapore ministers told a media briefing on Friday that the jump in COVID-19 cases in the island of 5.7 million people had put ‘tremendous’ pressure on its healthcare system.”
@thane_black
Common dynamic: many think they r “encouraging” your symptoms if they recognize or give credence to the symptoms you “claim” r happening. If blood isn’t oozing out of your body somewhere, they’re really not sure if you’re really hurt or just trying to get away with something.
Link between SARS 2 vaccines & Long Covid–like illness starts to gain acceptance | Science | AAAS
It is NOT true that if you’ve tolerated SARS 2 vaccine before then you will not get Long Covid symptoms from later boosters. The science is already clear.
And the above assessment does not even include the fair probability of a new coronavirus variant, especially one that pierces prior immunity. Even 1 that already exists, Mu, is holding its own against Delta in Columbia. It may be waiting in the wings post Delta. H/T
@DrEricDing
“If the health care system gets overwhelmed, that’s when we know from experience everywhere that doctors are unable to cope and you have death rates start to go up,” Mr. Wong said. “So we are trying very hard to avoid that.”
@sri_srikrishna
So sorry for your loss. People need to listen to your wisdom. Especially now, with so many people getting infected with SARS 2, they are set up to have pneumonia with a more serious outcome if just one other virus or bacteria gets involved.
@EricTopol
Look how high your risk is for cardiovascular incidents in the first 4 wks after Covid. You may have microclots and you shouldn’t be exercising immediately with those. More damage occurs in the penumbra if you increase oxygen needs to the tissues….
Important UK study look at new diagnoses of diabetes & heart problems in year following covid. They included 430K people with Covid and 430K matched controls.
Risks were higher for both - much much higher for cardiovascular problems.
Covid risk isn't just the initial illness.
@doctorasadkhan
Here’s a psychiatrist that has been advocating for Long Covid patients from the beginning. As soon as I saw the same sort of symptoms we see in concussion, otherwise known as traumatic brain injury, it was clear where this was going. MANY types of physicians do not have adequate
@LauraMiers
I love that they put COVID-19 illness 3rd in the list as if it’s less important, less severe, & not THE main cause for respiratory illness & death in the last month during the peak of a surge that was close to the same # infected as in the Delta surge. 3/
@ahandvanish
Couldn’t agree more. Delta has changed the game. You cannot make decisions today based off of old, outdated research on past variants. We have world data that shows the asymptomatic vaccinated & the symptomatic vaccinated are transmitting Delta to others at a significant rate.
Our current health policies still derive from assessments of vaccine efficacy made in April. Delta should be forcing us to revisit those assessments, but instead CDC clings to the past. The public health system needs to get ahead of the problem, not fight the last battle.
@MackayIM
@HamsonNed
CoV2 will never be the flu because it is neurotropic and has a SAG (superantigen). CoV2 will never be the flu because it is one of the most transmissible viruses in history. CoV2 will never be the flu because it evades and injures the immune system in a much more sinister way.
@NerdBurns
@EricTopol
Yes. This is what is happening until proven otherwise. Immunoprivileged sites= likely Covid hiding spots
The brain, the eye, pregnancy, and the endocrine tissues such as thyroid, parathyroid, adrenal, and islets of Langerhans.
@PhysioMeScience
You don’t exercise through this. Rule out your patients for POTS, PEM and ME/CFS subtype of Long Covid before any exercise program or risk permanently injuring your patients further.
EVIDENCE VACCINES SIGNIFICANTLY LOWER RISK OF LONG COVID
The Convalescence study at King’s College London to be published later this week, “show that vaccination substantially reduces the risk of long Covid.”
@Bob_Wachter
A is not true. Epidemiological estimates put it at 40-60% of the population will get it. There are plenty of people working from home & having groceries delivered who will not get it. If you don’t walk into the blizzard and the sun begins to shine again, you’ve let it pass over.
@DrLeanaWen
@PostOpinions
Many physicians don’t think u r clear-sighted, as you say, in regards to Long Covid in children & adults. Physicians that actively manage Long Covid cases feel that u r minimizing the significant impact of this multisystem vascular & respiratory disease on many people’s lives.
All that to say: I am *very* concerned about long COVID hindering my child's development. My concern about long COVID is grounded in scientific research, as is my confidence in the notion that masks have not (and will not) delay my child's language development.
And what does this mean for the US or many other countries in the world that are fairly vaccinated? We repeatedly hear estimates that only 5% of Americans have been infected with Delta. Many Americans are more than 4-6 months out from their last infection or their last vax dose.
@thane_black
Sometimes people r so simple. If they can’t 👀 it, they don’t believe it. Just like concussion. Teachers/ admin demanding concussed child take test this week bc all other kids r taking. Would u do this to child who broke their leg? Force them to run the mile bc other kids r?
I’m also a physician and I stand in solidarity with you and
@farid__jalali
.
I also get harassed for wearing an N95 or a KF94 to protect patients, my family, my friends, or myself.
Stay the course Julia.
Was just harassed on
@IrishRail
for wearing a mask. Passenger was blatantly taking photos of me, shouting, making faces and hand gestures to tell me he thinks I’m crazy.
I shouldn’t feel unsafe for wearing a mask. But that’s the reality we live in thanks to failed public health
@hjelle_brian
I sure hope so but SA doctors and some in NJ supposedly convinced:
Epidemiologist & Chief of Infectious Disease at University of Buffalo:
“Yes, you can get Omicron twice,”
“Doctors in [South Africa] had seen several people who had Omicron reinfections.”
@Dakota_150
The people who tested negative for SARS 2 were not necessarily free of SARS 2 in their bodies, especially if they had all the symptoms that are typical for acute Covid or Long Covid. Just because you turned up negative for a nose swab doesn’t mean it’s not somewhere else.
@BNODesk
Don’t Look Up
@AP
. Don’t give excuses for not reporting hospitalization numbers when every patient, regardless if they came in for Covid or with Covid, takes up extra hospital services & adds significantly to the overload. Just keep reporting u need more brkdwn of hospital #’s.
@LauraMiers
Second wave of trauma when your story is misbelieved, mistrusted and maligned. People need to listen👂and not declare you are fine when you know better.
@SamMc413
Excellent!! One thing that’s missing here is clearly stating that we have evidence all over the body of cell death/tissue death. We know the microclots cause things like micro strokes, micro heart attacks, micro brain injury. A lot of small areas dying off =‘s significant damage.
@ahandvanish
And don’t forget this study Hannah: New CDC study finds that 36% of COVID patients *never seroconvert*, meaning they NEVER make SARS CoV-2 specific antibodies.
We need follow up studies with a larger n but this helps explain a bit of what we’ve been seeing. 1/2
Who is helping these people? Are we denying their condition even exists? Are we minimizing how debilitating it can be? Are we minimizing how many people in our communities have Long Covid or more aptly, Long SARS 2? Who is giving hope and a listening ear instead of gaslighting?
“After the first year is when it really dawned on me that I wasn't going to get better and that was a very low point for me. That was quite difficult and I was suicidal for a while. I'm sure there have been lots of suicides because of
#LongCovid
because life becomes very bleak”
@j_g_allen
@PostOpinions
You want to do away with MASKS for good?? Right…. Read this. Just because we come down the other side of a surge does NOT mean we won’t have another & in the average of 2 months time or less.
Singapore is surging. We will have multiple “Singapores” here in the US. Their surge is higher than any they’ve had. 83% fully vax’d @ the time of this graph.
Does this look like u can’t surge if u have a significant amount of vax in your country or state? US is 57% fully vax’d.
@7NewsBrisbane
@G_Chumbley
They need to adjust this reporting. @ present, ~5% get more severe & notably disabling Long Covid while ~20-30% get Long Covid w/ its gamut of overt & silent body damage, varying levels of disability (mild, mod & severe), & varying lengths of symptoms (4+ wks - over 2.5 yrs).
@SamMc413
Be sure to add this: SIGNIFICANT DESTRUCTION/LOSS OF BRAIN TISSUE/BRAIN INJURY DUE TO COVID INFECTION
1st major study to compare brain imaging of 394 people before & after COVID illness.
Almost all - 96.2% - weren't hospitalized, but the study still found brain loss…
@EricTopol
Delta has changed the game. We will have multiple Scotlands here in the US. Their surge is higher than any they’ve had so far. 49.1% fully vax’d.
Does this look like u can’t surge if u have a significant amount of vax in your country? The US stands at 46% fully vax’d.
@AmeshAA
They are NOT medically insignificant. When a significant number of asymptomatic vaccinated and symptomatic vaccinated are transmitting to others, they need to be tested to pull them out of the transmission chain through quarantine.
⚠️Message to the world 🌎⚠️
-sent from Israel,
@Meir_Rubin
Vaccinate your kids AS FAST AS POSSIBLE and KEEP TRANSMISSION DOWN as much as possible “until you have a vaccine for the last kid in your country.”
-Professor Meir Rubin, Executive Director Koholet Policy Forum, Israel
@sri_srikrishna
Though unlikely as it wasn’t rampant yet, it is possible she had SARS 2 before this as we now know it was in circulation in November and December 2019 as well as January 2020.
@lisa_iannattone
We have known this since the SARS 1 data. SARS 2, just like SARS 1, leaves people more susceptible to pneumonias, upper respiratory infections, colds and coughs.
@DoencaProf
@emilygraymd_mph
You can emphasize that only “the vulnerable” will get injured by the virus now & us strong people can ignore it & anyone injured by it. Don’t mention that healthy young people get Long Covid all the time & that vax only protects from LC an extra 25% *if* you are recently vax’d.
Outdoor structures: “Outdoor risk increases if you’re in a wedding tent or structure where 3 sides are enclosed. “I don’t classify that as outdoors,” says Dr. Volckens. “The air exchange is limited. The air is more confined so the accumulation of this exhaled air is rebreathed.”
@EricTopol
@hjelle_brian
It may have improved ability to better chronically infect someone. We have cases of chronic infection due to previous variants in the non-immunocompromised confirmed by genomic sequencing. Omicron should be monitored for its ability to chronically infect or create Long Covid.
@WesElyMD
Cognitive challenges just like these can also be seen after concussion, o/w known as traumatic brain injury. Very specific errors in spelling &/or math, very specific speech pattern errors.
(I know you know this
@WesElyMD
but this is for all your readers)
@VPrasadMDMPH
Why? Because you don’t want kids and adults to have proof that they had Covid so when they’re disabled by Long Covid, they don’t have any chance of support (need a positive test)?? You can get Long Covid symptoms immediately or it can take a few months before it becomes clear….
@BNODesk
Do not be fooled that it’s a milder disease when it has mostly infected young people at the beginning of this outbreak. Do not be fooled that it’s a more mild disease if it takes longer for people to show symptoms. The data is not in yet so do not assume.
59:30- how severe is this variant? Should know in next few weeks & do not be fooled that it’s milder disease bc that’s how it can initially spread even though it is ultimately more severe. Need to also see what happens as it moves out of the younger individuals into the older.
@PhysioMeScience
You forgot to check your Long Covid patients for PEM. If you exercise them, you can make them permanently worse for life. First Do No Harm.
“Many people have long considered outdoor activities safe but scientists say it makes sense to rethink that assumption in certain situations. Delta increases the risk of outdoor transmission—especially for unvaccinated people, scientists say.”
@erinbiba
It would be more than reasonable to mask up outdoors if you know you may briefly enter someone’s airstream, especially if you are within 6 ft or less of them. Strongly consider outdoor masking if your case rate in your community is “high” or above.
@medriva
In the US we’re 17,000 deaths over 1 million at this time point according to Worldmeter. We hit 1 million deaths during the beginning of the recent push to get rid of mitigations and masking. The pandemic is not over & the surges in the US r not “mild”, even the most recent one.
@joncoopertweets
ABSOLUTELY. I know it’s airborne & I know all the risks for my body even if I merely get asymptomatic, mild or moderate Covid illness. I also know my vaccine effect wanes substantially each month. I’m no dummy. I’m wearing a high efficiency mask bc MASKS DON’T WANE.
Covid is not the flu and it will never be the flu. Past Covid infection, even that NOT requiring hospitalization, might become one of the highest risk factors for cardiovascular outcomes and surpass the risk created by smoking or obesity.
@michaelzlin
@PaulSaxMD
“Over prescription?” So all we care about is whether they’re hospitalized or die? Using Paxlovid to decrease Long Covid is equally as important. 20 to 50% of patients w Long Covid also meet criteria for ME/CFS. That form of LC is lifelong & truncates lifespan by ave. of 25 yrs.
@MdRisette
I’ve seen > usual reports of stillbirths after mothers recently infected. I’ve gotten reports from fellow physicians who r seeing > blood clotting issues in Covid patients. Kids r showing ⬇️ platlets & ⬆️ d dimers due to
#Omicron
. These kinds outcomes need be followed closely.
@michael_hoerger
through house now & cognitive dysfunction/brain fog that forced this straight A student to have to leave in person school & return to virtual. Headache continuously & @ times 8/10 pain. Sleeping much of day like patients do after a new concussion (o/w known as brain injury).
@toomuchSP
@Bob_Wachter
YES YOU MUST MASK AFTER OMICRON INFECTION. Repeat omicron infections seen in a short time period.
Chief of Infectious Disease at University of Buffalo, Stanley Weiss, M.D. :
“Yes, you can get Omicron twice.”
@MonicaGandhi9
Not likely from pathophysiology? You must not stay in the theoretical when we already know in real world data that the majority of young adults w/Long Covid get it from asymptomatic to mild illness. Go pour over all the ONS data which is some of the best data in the world on LC.
You said “seeing was believing”
@michaelzlin
, but so few listened. We knew asymptomatic vaccinated & symptomatic vaccinated were transmitting at significant rates nearly 1 1/2 months ago.
@DrEricDing
also picked up on yours &
@Ayjchan
’s outstanding work.
@LauraMiers
We can also see that in patients with multiple concusssions (otherwise known as traumatic brain injury) and it can be a longterm symptom: the attenuation or loss of hunger/thirst.
@DoencaProf
@emilygraymd_mph
You deserve to get on w the appointment so you should rapidly reassure your patient that they’ll be just fine w/out masks. You should then wave your hand over your HEPA filter to prove it is on & proclaim to clinic it is on but so quiet. Of course, it’s actually OFF.
Dr. Ugur Sahin, Founder of BioNTech
@VirusesImmunity
Virus is “just beginning” to escape immune responses. Other molecules may be involved in uptake of the virus & entry of virus. The spike should not be our only focus. Prepare for unexpected evolution.
@trvrb
Keep in mind the IFR of influenza is not well compared to SARS CoV2. They r not the same virus. CoV2 is like a cross between influenza & HIV. Once you’re infected & “recovered” it’s not necessarily over. On top of that, influenza never caused damage throughout the body like this.
@EricTopol
Generally, atrophy is not partially reversible. Damage like this does not disappear & brain volume does not return. Atrophy represents millions of dead cells. The brain can try to heal by rewiring around the damage/through other pathways but that is not always possible.
Cortical atrophy occurs even in those who have merely had asymptomatic & mild Covid. Bio bank studies keep showing us the truth about Covid infections & their ability to cause brain injury. This is not a rare phenomenon. Too, light & sound sensitivity typical brain injury symptms
@ArtKorenevsky
@macroliter
@amillerphd
@fitterhappierAJ
@adamhamdy
@mikejohansenmd
No. No one said 100% of people that get Covid to will have brain injury. We are saying the study from the UK shows we have a significant number of people who merely had asymptomatic, mild, & moderate Initial illness that have gone on to have relatively sudden cortical thinning.
@RisingWarrior3
@jasmith_yorku
Is that what you would say to your physician for wearing the exact same mask? That physician is putting their life on the line to save you and others. Warriors will wear whatever it takes to do the right thing. This is the look of a warrior.
"Living with it": Duke University, 98% of students and 92% of employees are fully vaccinated. In first week of school 364 cases, indoor dining suspended, back to remote teaching, student activities limited..
#auspol
@ScottGottliebMD
Now please talk about how much Long Covid we have in children in the US & do not base that assessment off of only US data. Compare to other countries such as Israel & UK that have quality research in these areas.
This is data from the UK’s ONS through the end of Nov 2021.
@MLS_Dave
The elephant in the room is there is still a SARS CoV2 pandemic going on in the world AND in the US that is wreaking havoc on different host immune systems such as those found in humans and rodents.
@BlumbergSeth
And where in your theory is the change in the hosts? Human hosts and rodent hosts have been impacted by SARS CoV2. Dysregulated immune systems and lymphopenias allow for outbreaks of organisms that were previously held at bay.
@vipintukur
If they don’t consider a severe event to include severe Long Covid, whether MECFS subtype or no, this is not a valid study. Those with severe Long Covid can have a quality of life equal to that of a cancer patient on chemo or end-stage AIDS. MECFS subtype= lifelong condition.
@michaelmina_lab
Infection + 1 dose of vax is NOT good for longevity though. It is also NOT good for quality of life/not becoming disabled. Damage to the body from each infection compounds.
@mugecevik
Severity should also be ranked by how disabling the infection is long-term, the virus’ ability to chronically infect even the non-immunocompromised, and how often it leads to foreshortened lifespans (i.e. only living another 2, 5 or 10 yrs due to complications).
Singapore is surging. We will have multiple “Singapores” here in the US. Their surge is higher than any they’ve had. 83% fully vax’d @ the time of this graph.
Does this look like u can’t surge if u have a significant amount of vax in your country or state? US is 57% fully vax’d.
@AmeshAA
They also need to get testing because a % of asymptomatic vaccinated will get Long Covid and many will have trouble getting care if they do not have their Covid + test to prove they had it. So many are gaslit, especially if they never went in to see if they were truly + or not.