EMBO Workshop SUMOylation: From discovery to translation 22 – 25 September 2025 | La Grande Motte, France I am sure this will be a good one😊.

This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.

@MCB_Sheffield @ScienceShef @sheffielduni This study, to our knowledge, is the first to investigate the role of protein SUMOylation in maintaining mitochondrial quality during hypoxia, a critical physiological stressor impacting cellular health.

For the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.

@MCB_Sheffield @ScienceShef @sheffielduni In this paper, for the first time, global deSUMOylation, particularly deSUMO2/3-ylation, was shown to enhance basal and hypoxia-induced mitophagy, and FIS1-TBC1D17 interaction was observed at endogenous levels.

'we propose a novel SUMOylation-dependent pathway where the SENP3-FIS1 axis promotes HIM, with TBC1D17 acting as a fine-tuning regulator.'

@ShengnanYuan

@BCiani Thank you! 👍

SENP3 knockout mice exhibit embryonic lethality at day 8.5, characterised by a neural tube defect and abnormal cardiac asymmetry (left-sided).

MiDs - MFF - DRP1 actions in mitochondrial fission

"Overall, base editor screening of PTM sites provides a powerful platform to dissect PTM function within signaling pathways."

Collaboration between the mitochondria and the nuclei in protein making

"#1 out of 140 UK Universities"

Chronic but not acute nicotine treatment ameliorates acute inflammation‐induced working memory impairment by increasing CRTC1 and HCN2 in adult male mice - Wang - 2024 - CNS Neuroscience & Therapeutics - Wiley Online Library

SENP3 again⁉️ 🧐 "In Alzheimer’s disease (AD), the BLA base model 654 identified seven AD-associated genes (DTX1, C3orf37, MEX3C, INPP1, USP32, YPEL2, SENP3)"