A statistical approach for systematic identification of transition cells from scRNA-seq data

New paper from our group in @Nature by @YiyunLin_YL @junkewang @KaileWang and team reporting the unexpected discovery of aneuploid epithelial cells (3%) in normal breast tissues from healthy women raising the question of when is cancer really cancer?

Menin inhibition is a standard of care! FDA approval of revumenib!! So happy to see that the benefit witnessed in patients on study is leading to a medicine to all who need it. Ready to forj ahead with more to come! ;)

Excited to share our manuscript published in @ScienceTM, where we describe a novel NK immune evasion strategy in AML. We found that #BATF is a key transcription factor driving epigenetic reprogramming in NK cells in AML. This TF is induced by the canonical TGF-β/SMAD pathway and leads to persistent NK cell dysfunction. This dysfunction can be prevented by deleting BATF or TGFBR2 upstream, but once established, it cannot be reversed. Designed to overcome epigenetic scarring, we look forward to bringing this novel CAR-NK cell approach to the clinic to improve outcomes for AML patients. @mdandersonnews @lab_rezvani @bijender2050 #AML #NK #CRISPR #epigenetics #BATF

#SBS2024 in full swing! full room for day 1. Great atmosphere! Fantastic talk @ErinMcCaffrey14! @CandaceCLiu @Walk14Cameron @Bendall_Lab @MikeAngeloLab

Delighted to share our latest research published in @Cancer_Cell Cell. Our study shows that intratumoral administration of IL-21 engineered NK cells resulted in strong and sustained antitumor activity against glioblastoma compared to IL-15 NK cells, which carried significant toxicity when administered intracranially in multiple orthotopic mouse models. We also discovered the critical role of the CEBP family of transcription factors, particularly CEBPD, in maintaining the potency of IL-21 NK cells. Congratulations to @Mayrashanley and many thanks to our collaborators. @FrederickLangMD, Juan Fueyo MD, Cande Gomez-Manzano MD, @abhinavjain_phd, @kchenken. Looking forward to taking this to the clinic! #CancerResearch #Glioblastoma #NK #immunotherapy #cytokines #IL21

Deep learning advancements change how we address challenges & bottlenecks in #SingleCell biology. See how researchers are transforming what's possible using existing data to understand health + disease with cutting edge computational approaches