Dr. Catherine Tooke
@kcat_Tooke
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Prize Fellow in Antimicrobial Resistance at the University of Bath. Investigating the mechanisms underlying beta lactam antibiotic action and resistance.
Bristol, England
Joined April 2016
Delighted to see our latest work out in @J_A_C_S We use kinetics, crystallography and simulation to investigate carbapenem hydrolysis in the versatile KPC-2 beta-lactamase. @Spencer_D60 @Michaelbeer777 @phil_hinchliffe @SchofieldOxford @AdrianMulholla1
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RT @Gingermicrobe: Come and join us here in beautiful Bath @lifesciencebath where we have lots of exciting microbiology going on! If you’re…
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RT @Michaelbeer777: Out now in @ACSCatalysis, we show that active site electric fields are a determinant of carbapenemase activity in class…
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An absolutely stellar morning session on the first day of the Great Wall symposium 2023! ... the location isn't bad either... #GWS2023
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Another #PhD opportunity for Sept 2024 led by @Spencer_D60 to investigate B-lactam antibiotic action and resistance with a combination of structural biology and molecular simulations co-supervised by me, @marcvanderkamp and @AdrianMulholla1 !
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RT @marcvanderkamp: #PhD opportunity for Sept 2024: @GW4BioMedDTP project on overcoming Class C β-lactamase mediated #AntimicrobialResista…
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Very excited to start as Prize Fellow in Antimicrobial Resistance at the University of Bath today! @LifeScienceBath.
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I had a great day at #ASMicrobe, some really interesting sessions and nice to present a poster on my KPC investigations ft. @Michaelbeer777 and @phil_hinchliffe from @Spencer_D60.
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Spectacular talk at the 14th annual beta-lactamase meeting by Prof. Robert Bonomo. Beautifully putting current clinical challenges in perspective and demonstrating the urgency and need for a continuous BL inhibitor pipeline
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RT @pintofscience: #pint23 is getting very close! Science talks in relaxed atmosphere for 3 nights, come meet and chat with scientists! N…
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RT @ProfRuthMassey: Latest paper from the lab, work of @Dora_Bonini with help from @alnaharialaa1 @SeanaDuggan Tarci and @HenrikStrahl Whe…
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RT @CMMBristol: IT'S TODAY!! Jim is proving to be so popular, we have opened up a few more spaces for his inaugural this evening, click on…
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RT @jordanesealey: Fancy a pint? Join us in the pub for a pint (23rd May) where my colleagues and I will be giving talks at #pintofscience…
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RT @CMMBristol: We are excited to announce Prof Jim Spencer @Spencer_D60 will be presenting his inaugural lecture on Thur 4 May at 5.30pm,…
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RT @Michaelbeer777: Happy to have contributed to this, out now in @J_A_C_S, examining what defines KPC-2 beta-lactamase’s activity! Togethe…
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RT @Michaelbeer777: Out now in preprint! Led by @kcat_Tooke we use high resolution crystallography and QM/MM umbrella sampling simulations…
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Our latest work detailing how omega-loop stability and carbapenem acyl-enzyme tautomerisation define activity of the KPC-2 beta-lactamase is out in pre-print. @phil_hinchliffe @Michaelbeer777 @AdrianMulholla1 @Spencer_D60 @SchofieldOxford
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Thanks Jim, it was a fab lab day out!
First summer lab day out since the BeforeTimes- tour of @PenderynWhisky, a walk and a wild swim in the wonderful Brecon Beacons. Thanks to the group for a great day!
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