@ksamocha @ksamocha how does this fit in with the 8% estimated to be explained by common variants from the 2018 paper? Is the 8% on top of the 25% or a part of it?

What can 45,000 exomes tell you about GWAS and core genes? Come ask the always classy @PeterDornbos from 2-3PM at #ASHG19 poster 2804

Actually , I can't promise that. But we can discuss anything related to the @T2DKP , @KPortalNetwork , or our recent nature paper on large-scale exome analysis

RT @npburtt: Interested in scientific software & methods for moving for complex disease associations to targets? Come talk with Jason Flann…

Is a p=0.02 association real or not? It depends on the gene. See Lokendra Thakur talk about our method for gene prior calculations at #ASHG19 Room 371A/4:45pm

If you are only half interested, just come for the snacks!

RT @T2DKP: The @T2DKP is hosting an ancillary event at #ASHG19 Foundational Resources for Translating Genetic Associations to Function & Ta…

Looking forward to #ASHG19. If you are attending and interested in postdoc opportunities in exome analysis or integrative computational genomics, message me and we can chat about opportunities in

And (2) solid evidence that toxicity can be predicted as well (well-done analysis in this one as well)

In particular (1) coding GWAS variants seem to increase likelihood of success even more than the two-fold reported earlier for arbitrary GWAS

Was reviewing some work on genetics + drug targets and found these to be of interest: and

@SA_Diabetes @npburtt @markmccarthyoxf @anubha_M_Oxf @obahcall Interesting thing is: w/ what we know about SLC5A2 other than the genetic signal, could we detect it much sooner?

@SA_Diabetes @npburtt @markmccarthyoxf @anubha_M_Oxf @obahcall Of course, this is a pretty rough estimate w/ all of the potential factors that can influence an observed p-value

@SA_Diabetes @npburtt @markmccarthyoxf @anubha_M_Oxf @obahcall @SA_Diabetes Assuming that the true combined OR/MAF of variants in SLC5A2 is the same as what we observe, yes

Our new study of coding variants and T2D shows that rare variants contribute less to T2D than we thought a decade ago, but may be more useful than we thought three years ago: @T2DKP @npburtt

RT @obahcall: New analyses on the genomic architecture of T2D & contribution of rare variation, with lessons for rare variant studies. Exo…