Hojong Yoon
@hojong_yoon
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Assistant Professor & CPRIT Scholar @MDAndersonNews Interested in Protein degradation, Induced proximity, Small Molecule Drug discovery
Joined December 2014
Mind-blowing masterpiece by @brian_b_liau @LabZheng
Today in @Nature we share our back-to-back stories with @nzhenguw revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6
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We have an exciting, unpublished ongoing project, and Iād be happy to discuss the details! Feel free to reach out! (6/6)
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@JoseAVelilla2 @HHMINEWS @AashishManglik @RachelleGaudet Congrats Jose! Fantastic news and well deserved!
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Join us for the final TPD webinar of 2024 on 12/19. @FleurMFerguson & @eswang01 - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC" Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
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Orgchem or biochem folks! How do you manage an enzyme-catalyzed synthesis when your starting material crashes out upon mixing with your protein? It works well on a small scale, but scaling up becomes tricky. Any tips or tricks?
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@QuinlanSievers I don't remember the exact error message but I've had similar issues before, and yes submitting multiple times usually did the trickš
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Can't wait!!!
We are thrilled to have @georg_e_winter @CeMM_News return to the DFCI TPD webinar this Thursday! Georg will talk about how inhibitors can supercharge endogenous degradation mechanisms. Very much looking forward! šJoin us at 12 PM EST/ 6 pm CET (hybrid format)
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The journey from drug screening to mechanistic elucidation and its applications is simply remarkable. While itās reasonable to claim that ACE is a monovalent degrader, Iām not fully convinced whether this compound acts as a molecular glue or induces potential allosteric effects.
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RT @norbertkraut1: A must-read! The #DepMap portal is used extensively by the research community to assess gene functions in #cancer, nominā¦
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Excited to kick off our post-summer series! This Thursday we are hosting @gpsapkota sharing insights on redirecting phosphatase through induced proximity. **Important: The time has changed to 12 PM EST!
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RT @joshim5: Weāre excited to introduce @ChaiDiscovery and release Chai-1, a foundation model for molecular structure prediction that perfoā¦
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RT @kdonovan1008: Extremely excited about our next in-person TPD event. If you are in Boston on September 12th - sign up and join us for aā¦
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