Casey H. Halpern
@halpernc
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Chief of Stereotactic and Functional Neurosurgery Associate Professor of Neurosurgery University of Pennsylvania
Philadelphia, PA
Joined August 2011
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Our latest paper in
@Nature
explores a network connecting the lateral hypothalamus with the dorsolateral hippocampus that specifically responds to anticipation of sweet-fat food cues. This network exhibits dysregulation in obesity.
@PennNSG
@PennMedicine
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I wanted to share this video from one of my patients who underwent the focused ultrasound procedure for treatment of his tremor. Very excited to show everyone his incredible results and want to invite everyone to share their improvements and outcomes from treatment as well!
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Our latest paper in
@NEJM
describes how focused ultrasound ablation of the internal segment of the Globus Pallidus can help people with medication-refractory Parkinson’s disease.
@PennNSG
@PennMedicine
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Watch the magic of deep brain stimulation that inspired me to be a neurosurgeon. It’s like a light switch…and here you see the before and after side by side.
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Our latest publication in
@NeuroCellPress
describes the first-in-human application of responsive deep brain stimulation to treat obsessive symptoms in OCD. This paper embodies our lab’s mission to explore novel and effective applications for DBS.
@PennNSG
@PennMedicine
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I am proud to announce that on January 16th I performed the first-ever deep brain stimulation surgery with the latest Medtronic Percept™ rechargeable neurostimulator here at the country’s first hospital! It was a long time coming….but it was worth the wait!
(1/3)
@PennNSG
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Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating | Nature Medicine
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I wanted to share this video from one of my patients who underwent deep brain stimulation last week, and who I initially programmed in the recovery room following his procedure. It’s these kinds of incredible results for tremor that inspire me to do what I do everyday.
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Findings in our latest paper in
@ScienceTM
suggest a neural circuit that links habit development and binge eating behavior in humans. This could, in part, explain the treatment-resistant behavior common to eating disorders and other related psychiatric conditions.
@PennNSG
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In our latest paper, we identify a novel deep brain stimulation (DBS) target for the treatment of medication-resistant OCD.
@PennNSG
@PennMedicine
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I’m proud to announce that I have performed the first Medtronic Percept RC rechargeable deep brain stimulator for a US Veteran at the Philadelphia VA. The sensing capability of this unique DBS system provides us with the potential to tune stimulation delivery …
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I am proud to be the first in the country to offer our patients the recently approved Vercise™ 2-in-1 Deep Brain Stimulation Extension, which combines 2 extensions into 1 and is the smallest extension on the market, designed to improve comfort and aesthetics.
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Having returned to Philadelphia where I grew up, I often have the pleasure of taking care of my family and friends. This lovely patient happened to be the father of a friend from high school! Means a lot to me to be able to help people I know with their tremor! Amazing result!
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This recent article in Wired gives great coverage of our recent Neuron publication of a novel form of deep brain stimulation for OCD. The patient in this case study went from spending a third of her day performing compulsions to only 30 min per day…at most!
@PennNSG
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The Halpern Lab, run by Dr. Casey Halpern, Chief of Stereotactic and Functional Neurosurgery at the University of Pennsylvania, is hiring! We are looking for scientists from a wide range of backgrounds and levels to join our multi-disciplinary team (1/5)
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Recent
@nytimes
article describing the use of deep brain stimulation (DBS) to control cravings. Thanks so much to our incredible patients for sharing their stories and how much DBS has helped them.
#neuroscience
#Neurosurgery
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Had a great conversation with
@andreashorn_
on
@stimbrains
about our research on loss of control of eating and OCD, the future of neurosurgery, the importance of scientific collaboration and so much more.
Dr. Horn is a wonderful colleague and I really enjoyed our conversation.
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Thought you all would enjoy this podcast on deep brain stimulation and beyond with my close friend
@hubermanlab
@PennNSG
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Specifically, connectivity in this circuit is inversely proportional to BMI. This work expands our understanding of appetite-regulating circuits in the brain and explores a network that has the potential to become a therapeutic target in the future.
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One of the first FDA approved use of focused ultrasound to treat second side tremor.
Thank you to our team for their incredible work and to our patients for their trust in us.
@PennNSG
@PennMedicine
#tremor
#neurosurgery
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Thank you to
@cbsnews
for featuring our clinical trial investigating the use of deep brain stimulation to treat binge-eating disorder.
@PennNSG
@PennMDForum
#neuroscience
#neurosurgery
#DBS
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Our latest paper discusses the promise of deep brain stimulation (DBS) as a treatment for treatment-resistant depression.
@DanBarbosa39
@molpsychiatry
@PennNSG
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Shout out to
@bostonsci
for hosting a terrific holographic course on brain anatomy to guide deep brain stimulation surgery. Truly mesmerizing!
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Getting notes like these make the holidays that much sweeter. Happy Holidays!
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In our latest publication, we built on our prior work mapping tremors to map cravings in part of the brain named the nucleus accumbens.
@PennNSG
@PennMedicine
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Stepwise improvement of tremor during a Focused Ultrasound Procedure! This non-invasive treatment takes only a couple of hours and the results never fail to amaze me.
@PennMedicine
@PennNSG
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Deep Brain Stimulation, or DBS, is an excellent treatment for a variety of movement disorders. Next-generation implantable pulse generators (AKA, DBS batteries) have revolutionized the field, leading many patients to consider upgrading their existing DBS systems.
@PennNSG
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1️⃣In light of our new
@NeuroCellPress
paper, this thread will discuss the approach employed and the impact DBS had on our patient.
@PennNSG
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Such an honor to be recognized by the NRCDP. This federal funding mechanism was integral to support the research that led to our ongoing human trial of deep brain stimulation for loss of control eating.
Our final K12 scholar highlight of '22 is Casey Hallpern, MD. Halpern is Chief of Stereotactic & Functional Neurosurgery at
@PennMedicine
. His clinical focus is in the treatment of movement disorders such as Parkinson's, tremor, dystonia, Tourette, epilepsy & psychiatric disease.
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Extending the use of focused ultrasound to Parkinson’s tremor. Improvement in hand writing not just due to tremor improvement but also improvement in mobility following treatment.
#parkinsons
#Neurosurgery
#neuroscience
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A recent article in
@cbssacramento
described the story of one of our wonderful patients in our loss of control eating clinical trial, where we used deep brain stimulation (DBS) to help her control her cravings.
#neurosurgery
#neuroscience
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A recent interview in CBS Sacramento with one of our incredible patients in our deep brain stimulation for loss of control eating clinical trial.
#brainsurgery
#neuroscience
#neurosurgeon
#cravings
#parkinsonsdisease
#tremor
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It’s been 10 YEARS since this patient has been able to use her right hand w/o medication. Now, thanks to DBS her tremor is gone and she is able to start playing the saxophone again. I’m inspired by her resilience and continue to be amazed by how much DBS can impact our patients.
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More than 50% of solid organ transplant recipients report tremor, which can often be very debilitating. In this paper we describe how we were able to use focused ultrasound to treat a lung transplant recipient’s severe tremor.
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We look forward to continuing to study the role DBS can play in helping millions of people around the world who are affected by treatment-resistant OCD.
Check it out here:
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New article in
@PennMedicine
News discussing our latest publication in
@ScienceTM
highlighting how human habit neural circuitry may be perturbed in eating disorders
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If you’re interested in learning more about our work with OCD, check out this podcast I did with Christopher Cook
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This new article in Penn Today discusses our work using deep brain stimulation to treat binge eating disorder. Really excited to be recognized in this way by my institution where all of this work started years ago!
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Last month, we performed one of the first cases of focused ultrasound to treat the second side of an essential tremor patient. Here are some quick before and after videos. Thank you to our patients and incredible team for making this possible.
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My DBS and ultrasound patients with tremor often worry that I’ll have a moving target during surgery. This headframe keeps everything still so I can focus on the brain. About to start our third focused ultrasound here today. Great times here at Penn with no tremor left behind!
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Stepwise improvement of patient’s tremor thanks to focused ultrasound treatment. This non-invasive treatment allows us to make an incredible impact on our patient’s quality of life and the results speak for themselves!
#NoTremorLeftBehind
@PennMedicine
@PennNSG
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Finding ways to switch off compulsive food cravings.
For more information about our clinical trial please check out or reach out to Dr. Nida Firdous at nida.firdous
@pennmedicine
.upenn.edu or 215-829-6720
@PennMedicine
@PennNSG
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When targeting deep in the brain, patients often ask how we can ensure we are avoiding critical structures. A simple measurement as you can see here shows that my chosen target for tremor is sufficiently far away to avoid side effects by irritating the internal capsule.
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Join me on March 14th to discuss the latest in essential tremor and Parkinson’s treatment.
Register Now at:
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More education on tremor and Parkinson’s coming. See you March 14! Easy to attend this national webinar…hoping for a great turnout to provide an update on focused ultrasound.
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Last night was our inaugural lecture series on Parkinson’s and tremor at Princeton Public Library. Thanks to Dr. Ahmed Jaffer of Princeton & Rutgers Neurology for joining me in educating patients on treatment options and to team Boston Scientific for hosting a terrific event.
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The patient whose MRI I posted about earlier has had an amazing result today which is getting more and more typical in our experience. No side effects and you can see her baseline handwriting (on the left) has substantially improved (on the right).
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Check out this amazing video featuring our collaborator Dr. Cara Bohon, where she explains our work studying altered neural circuits in binge eating disorders to shed mechanisms as to why eating disorders are so common and challenging to treat.
In the latest 90 Seconds, Cara Bohon, PhD, clinical associate professor of psychiatry and behavioral sciences, discusses new research using brain imaging which may explain why these behaviors are so persistent and hard to treat:
#Neuroscience
#MedTwitter
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The sensing capability of this unique DBS system provides us with the potential to tune stimulation delivery to brain activity, which may be a way to personalize this therapy for Parkinson’s disease and beyond!
(2/3)
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Now with rechargeability, we can really leverage these novel capabilities for patients and examine their potential more fully. Thank you to Paul Sherlock, Sean Toomer, Greg Beideman and all the executives at Medtronic for helping us advance this incredible field.
(3/3)
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Thank you to everyone that has contributed to this exciting work. Perhaps this may be a new path to deep brain stimulation and even non-invasive techniques to help those suffering from these problems.
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Had a great time today! Thanks to the “Unshaken” PD Exercise Support group for their time. The “Unshaken” group is part of the Energy Lab led by Well-Being Coach Eric Bauberger BS, CSCS, located at Total Turf Experience in Pitman NJ.
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This large, multi-center, double-blind trial highlights both the efficacy and safety of this treatment, which has and will continue to help many patients!
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Join me and Debbie at the Princeton Library to learn about the team approach to Parkinson’s care. Physical therapy has a proven track record of helping patients with movement disorders.
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I’d recommend this type of incredible strength-focused therapy for all of my Parkinson’s patients.
#parkinsonsdisease
#physicaltherapy
#neuroscience
#neurosurgery
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Join me at the Parkinson’s Disease Symposium to discuss neurosurgical treatments for PD and learn more about living with Parkinson’s.
Register here:
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To brain activity, which may be a way to personalize this therapy for Parkinson’s disease in the future. What a wonderful way to thank our brave veterans for their service to this country.
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The capsule can be clearly seen in black on this unique MRI sequence. Stay tuned for this patient’s outcome.
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Register here for my talk about neurosurgical treatment for Parkinson’s disease:
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It’s crucial to precisely localize the site of cravings in the brain to be able to effectively apply deep brain stimulation to patients with binge eating disorder, obesity, and beyond.
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@CBSSacramento
People struggling with binge cravings opting for brain surgery via
@cbssacramento
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These guidelines leverage the strengths of each device as well as the patient’s goals, convenience, and compatibility with other DBS systems.
Check out this letter here:
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Tune in tonight to listen to my partner, Dr. Iahn Cajigas, speak on what focused ultrasound can do for you! Meeting Registration attached below…
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Thank you to Steve Korn, Emad Eskandar and the other K12 scholars and mentors for investing in the vision of young neurosurgeons!
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Our lab is currently recruiting participants for our loss of control eating trial. This trial is a landmark study employing the use of deep brain stimulation to disrupt binge cravings that often lead to the loss of control of eating.
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DBS technology has evolved over the years and we are pleased to offer all the options to our patients. We also find exciting that patients implanted with the old Medtronic system may benefit from an easy swap to these other batteries. (1/2)
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Join me next month at the Princeton Library to learn what you can do for Parkinson’s and Tremor beyond medications. I’ll be sharing the stage with my close colleague, Dr. Ahmed Jaffer. See you there!
#Parkinsons
#essentialtremor
#Neurosurgery
#neuroscience
#dbs
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These results were sustained over two years.
I’m incredibly proud of the work everyone in our team and our collaborators at OHSU have put in to make this work possible. Very much looking forward to helping more and more patients with OCD using DBS.
@raslanneuro
@DanBarbosa39
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We are currently recruiting participants for this clinical trial. For more information please refer to our pinned tweet for inclusion criteria. Also please check out or reach out to Dr. Nida Firdous at nida.firdous
@pennmedicine
.upenn.edu or 215-829-6720
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@andreashorn_
@stimbrains
@CaseyHalpern5
Such fun discussing the expanding horizons of DBS with Dr. Horn!
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Check out the article here:
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Next step, how do we scale what we are doing in the lab to get this therapy to the many patients who need it?!
More to come.
(3/3)
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Thanks to all the patients with essential tremor who have paved the way for the use of this treatment in patients with Parkinson’s.
#essentialtremor
#parkinsons
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This work is the latest in a series of studies by our team to discover new and innovative ways to use DBS and focused ultrasound to help people struggling with both psychiatric and movement disorders.
Check out the paper here:
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the lab is considering a staff or faculty position as an alternative if qualifications apply. For more information, share your CV and reach out directly to Dr. Halpern at casey.halpern
@pennmedicine
.upenn.edu. (5/5)
@DBSThinkTank
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This patient���s tremor improved so significantly that she came back to treat her second side! Our team is constantly looking for ways to expand the use of focused ultrasound and deep brain stimulation technology to new indications so that we can help as many patients as possible.
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I had the great privilege of sharing our exciting work on OCD, eating disorders and beyond with some of the most preeminent international deep brain stimulation experts.
(2/3)
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This study was conducted in collaboration with Dr. Robert Malenka and Dr. James Lock from
@StanfordMed
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@Dukeneurosurg
@GeraldGrantMD1
@DukeSpine
@DukeMedSchool
@Duke_Childrens
@AngelsAmongUsBT
No one more deserving of this honor
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Join us on Mission PD for a presentation with Dr. Casey Halpern.
Today: April 7, 2023 at 2PM EST
Zoom link below or join Mission PD at and see our virtual presentation thread for this and other presentations.
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There is a tremendous unmet need for evidence-based therapeutic options for these patients, and DBS can be a wonderful option, particularly in light of some recent studies that have evolved our understanding of this neural circuit disorder.
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Just posted a photo
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These other batteries have different features which may be more helpful to each patient. Share your preference with us in clinic and ask us about the swap option. (2/2)
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who can assume leadership positions on BRAIN Initiative and foundation-funded projects implementing invasive and non-invasive brain stimulation and recording techniques in treatment-resistant neurologic and psychiatric conditions. (2/5)
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We are looking for candidates who fit the inclusion and exclusion criteria indicated on the post above.
For more information please check out or reach out to Dr. Nida Firdous at nida.firdous
@pennmedicine
.upenn.edu or 215-829-6720
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