Hajime Ito
@haj19932469
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Chemistry Professor, Father of two daughters, Boronchemist, Mechanochemist, Deputy Director of ICReDD, Hokkaido University, Japan
日本 北海道
Joined August 2013
Our latest paper has been published! Direct Arylation of gem-Difluorostyrenes Using in Situ Mechanochemically Generated Calcium-Based Heavy Grignard Reagents, @ICReDDconnect, #mechanochemistry.
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We've discovered that ball milling commodity plastics serves as a safe radical source, initiating intriguing reactions! Surprisingly, a simple plastic bag from a supermarket can be employed in this process! @k0j1chem,@ICReDDconnect,@J_A_C_S.
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A nanobonsai was synthesised using the Si-iterative synthesis method as a demonstration. In fact, the synthesis was relatively simple. This may be useless, but it should be popular with high school students visiting the university!.
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Our new mechanochem paper has been published in Science. Congratulations Koji and Pang! #mechanochemsitry.Redox reactions of small organic molecules using ball milling and piezoelectric materials
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Sweet Birch! Addition of glucose as a solid proton source enables mechanochemical Na Brich reduction. Congraturations Kondo-kun! @k0j1chem, @ICReDDconnect, #mechanochemistry
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Our new paper has been published in JACS, Iwamoto-san, Ozawa-ku, and Imamoto-sensei, congratulations!!.
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Our latest paper has been accepted to .@J_A_C_S In situ crystallization controls the selectivity of Suzuki-Miyaura cross-coupling in ball mill. Congrats Tamae and Koji! #mechanochemistry .@ICReDDconnect
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Ultra-fast Birch reduction (< 1min typically) is now possible with ball mills, Congratulations, Yunpeng and Koji! "Mechanochemical Approach for Air-Tolerant and Extremely Fast Lithium-Based Birch Reductions in Minutes" @angew_chem @ICReDDconnect @k0j1chem .
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Our second "mechanoredox" paper has been accepted in Angew! Congratulations, Dr. Pang, Joo Won, and Koji!.
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Suzuki-sensei, a hero of our Hokkaido University!.
Happy 91st birthday to Akira Suzuki, born #OnThisDay in 1930. Suzuki developed the Suzuki reaction - a way for chemists to join carbon atoms together. They have been used to create polymers that emit light, to develop light-capturing molecules and more.
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Our latest paper on a new method for the synthesis of silylboranes has been accepted by JACS. Congratulations, Dr. Shishido Ryosuke, Minami, Rikuro, and Koji!.
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Solid-state cross-coupling reactions using mechanochemistry,#RSCPoster, #RSCOrg, #mechanochemistry,#ICReDD
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A new paper by Takumi and Avijit has been published in JACS. With this method, complex oligosilanes can be synthesized iteratively like DNA or peptides. We hope this opens up a new Si chemical space.
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We are happy to share our new results in @J_A_C_S. Congrats, Akiyama-kun, Oyama-san, Endo-san!.A Copper(I)-Catalyzed Radical-Relay Reaction Enabling the Intermolecular 1,2-Alkylborylation of Unactivated Olefins
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Our first paper for polymer mechanochem is now on Angew. Chem. Int. Ed. Introduction of a Luminophore into Generic Polymers via Mechanoradical Coupling with a Prefluorescent Reagent
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Our new paper for a shape memory crystal has been published to Chem. Sci. as 2022 Chemical Science HOT Article Collection. Congratulations Feng Chi and Dr. Seki!!.
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Congratulations Mingoo and Rempei! A collaboration paper with Marcus and Prof. Garcia-Garibay has been published!Encapsulating N-Heterocyclic Carbene Binuclear Transition-Metal Complexes as a New Platform for Molecular Rotation in Crystalline Solid-State
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Discussion with Ben List for our future collaboration at ICReDD in Hokkaido U! .@ListLaboratory @ben_list @ICReDDconnect
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Our latest @J_A_C_S is now online. Big congratulations, Tamae, Naoki, and Koji! #mechanochemistry.Tackling Solubility Issues in Organic Synthesis: Solid-State Cross-Coupling of Insoluble Aryl Halides
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Great news! We are thrilled to share that our paper has been chosen as the cover feature for the latest issue of @J_A_C_S
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Our new paper for a new chiral ligand has been published in JACS. Congratulations, Dr. Iwamoto, Ozawa-kun, Prof. Imamoto-sensei! Backbone-Modified C2-Symmetrical Chiral Bisphosphine TMS-QuinoxP*: Asymmetric Borylation of Racemic Allyl Electrophiles
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Our new paper has been published in ACS Catalysis! Ball milling improves the Suzuki-Miyaura coupling efficiency of C6F5B(OR)2 Congratulations, Rikuro, Tamae, and Koji! .
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Finally, our chiral Si-B paper has been published. Congraturations Xihong and the team! @k0j1chem @ICReDDconnect.
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Our new paper for designing ligand for Mechanochem has been out! Cograts Tamae and Koji!.Mechanochemistry-Directed Ligand Design: Development of a High-Performance Phosphine Ligand for Palladium-Catalyzed Mechanochemical Organoboron Cross-Coupling
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Our new paper has been published to Angew! Cograturations Koji @k0j1chem and Seo-san! Dual Nickel(II)/Mechanoredox Catalysis: Mechanical-force-driven Aryl-amination Reactions Using Ball Milling and Piezoelectric Materials.
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Our solid Grignard paper has been selected as one of "2021 Top 25 Chemistry and Materials Sciences Articles" in Nature Commun.
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Our new paper has been published in Angew! Cognates Pan and Koji! "Mechanochemically Generated Calcium-Based Heavy Grignard Reagents and Their Application to Carbon−Carbon Bond-Forming Reactions".
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Our recent paper for rapid mechano-synthesis of Ir(III) complexes has been published in ChemSci. Cograturations Tsubura and Koji-san!, @k0j1chem, @ICReDDconnect, #mechanochemsitry.
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Our paper for the first Si-chiral silylboranes is on ChemRxiv. Xihong Wang, Feng Chi and Kubota-senei.Stereospecific Synthesis of Silicon-Stereogenic Optically Active Silylboranes and their Application to Synthesis of Chiral Organosilanes.
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More convenient solid C-N cross-coupling in ball mill!.Congratulations, Rikuro, Minami, and Koji!.
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Cograturations for publication in JACS, Shiratori-kun! "Ring Expansion of Cyclic Boronates via Oxyboration of Arynes" ,@k0j1chem,@ICReDDconnect,@J_A_C_S.
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Our mechanochemical Sonogashira coupling paper has been published. Yunpeng, congratulations! This is particularly useful when using substrates with low solubility. @ChemicalScience, @k0j1chem .
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Zurich! I delivered a mechanochem talk in ETH, hosted by Profs. Jeff Bode and Yoko Yamakoshi!
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A new paper has been published in JACS! Congratulations, Ozawa and Endo-kun!.Regio- and Stereoselective Synthesis of Multi-Alkylated Allylic Boronates through Three-Component Coupling Reactions between Allenes, Alkyl Halides, and a Diboron Reagent
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Congratulations, Rempei and Mingoo, on your groundbreaking paper in Angewandte about Giant Crystalline Molecular Rotors! .@MingooJin.@angew_chem.
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Our new paper for borylation has been published. Congratulations, Oyama-san!.Cu(I)-Catalyzed Enantioselective γ-Boryl Substitution of Trifluoromethyl- and Silyl-substituted Alkenes.
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#MyOAarticle "Mechanochemical synthesis of magnesium-based carbon nucleophiles in air and their use in organic synthesis" received 24125 downloads since its publication! Access the article here:
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Our new paper has been accepeted in RSC Mechanochemistry! Direct arylation of alkyl fluorides using in situ mechanochemically generated calcium-based heavy Grignard reagents.@k0j1chem @ICReDDconnect
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Our paper Chem Sci has been highlighted in Chemistry World!.Mechanochemistry set to expand availability of organomanganese reagents:
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Prof. Kubota got The Chemical Society of Japan Award for Young Chemists for 2022! Congratulations!.
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Thrilled to announce my role as a member of the RSC Mechanochemistry editorial board!
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I completely agree with this. Originality is the most important value of a paper, and substrate coverage is one factor. The choice of substrates to illustrate is important, not the number. On the Topic of Substrate Scope.
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I very much enjoyed my first time in Cambridge and the dense discussions. Mechanochemistry: Fundamentals, applications and future Faraday Discussion, @Faraday_D, @Mechanochem
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Our new Angew paper has been accepted! Congratulations Iwamoto, Endo, Ozawa, and Prof. Imamoto! .
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Congraturations, Fukuzawa and Koji!.Highly Efficient and Air-tolerant Calcium-based Birch Reduction Using Mechanochemistry.
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Our paper has been highlighted!.‘Mechanochemistry strikes again’ – this time for deoxygenating phosphine oxides:
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Our new mechano-chem paper for C-H activation has been published in Chem. Lett. Congrats, Kondo-kun!.
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New paper of Rempei and Mingoo has been published! This is a precursor to our next study. Charge-Transfer Crystal with Segregated Packing Structure Constructed with Hexaarylbenzene and Tetracyanoquinodimethane - now published in CrystEngComm
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Snapshot of the Maruoka Conference in Nagoya with Eric Jacobsen, Mark Levin and Hiroki Hayashi (ICReDD) @LevinChem @ICReDDconnect @OoiLab_NU
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Following the pioneering work by Harrowfield, Birke, Hanusa, Yang, and Dai, we report a general method for the preparation of Grignard reagents using a ball mill; NEXAFS measurements confirm the structure of the reagents. Congratulations Rina!
Our paper on mechanochemically prepared Grignard reagents is finally out now in @NatureComms!! Congrats @rina_chemistry, @haj19932469 and the team! Great collaboration with Prof. Maeda @SatoshiMaeda15, Prof. Jiang and Prof. Takaya!.
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Tamae and Koji's paper has been selected as the JACS cover art!.Tackling Solubility Issues in Organic Synthesis: Solid-State Cross-Coupling of Insoluble Aryl Halides
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Our group's first paper of the year has been published. Congratulations, Ozawa, Koriyama, and Shiratori-kun!.Copper(I)-Catalyzed Regio- and Stereoselective Silaboration of Terminal Allenes
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I am excited about the great cover art for the Faraday Discussion on mechanochemistry!.Front cover - now published in Faraday Discussions
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Japan is an earthquake-prone country, but yesterday's early New Year's quake seemed to be a pretty strong one, and I have never heard of a big one on January 1. Fortunately we were OK, but I would like to express my sympathy to the people in the affected areas.
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After US, I also flew to Spain to give an invited talk at the @GordonConf in Casteldefells as an invited speaker. This is a mechanochemistry talk! #mechanochem, @ICReDDconnect
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Emeritus professor of our Hokkaido University, Congratulations!.
Happy 90th birthday to Akira Suzuki, born #OnThisDay in 1930. Suzuki developed the Suzuki reaction - a way for chemists to join carbon atoms together. They have been used to create polymers that emit light, to develop light-capturing molecules and more.
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Interesting paper: Mechanochemical Fabrication of Full-Color Luminescent Materials from Aggregation-Induced Emission Prefluorophores for Information Storage and Encryption | Journal of the American Chemical Society
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It was very honored to be invited to give a talk about mechano oragano synthesis at the 133rd General Meeting of the Korean Chemical Society with Mu-Hyun Baik, @baikkaist, Eric Carreira, @J_A_C_S, and Michael Krische, @KrischeLab!!
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Our Mn mechanochem paper has been selected as one of the Most Popular 2023 Chemical Science Articles!.
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Our ultra-fast Birch reduction through mechanochemistry was featured in Derek Lowe's commentary in the Science journal. @ScienceMagazine @k0j1chem @Dereklowe.
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I found a beautiful flower arrangement in town after dinner. I gave it to my wife.
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Assistant Professor Dr. Tomohiro Seki in our laboratory received the 2019 Progress Award of Chemical Society of Japan. This is given to researchers who got outstanding achievements under the age of 36. Congrats! Special thanks to all the persons involved.
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Our paper has been highlighted as a front cover art of Angewandte!.
#OnTheCover Introduction of a Luminophore into Generic Polymers via Mechanoradical Coupling with a Prefluorescent Reagent (Ito) @k0j1chem @MingooJin @haj19932469 @HokkaidoUni
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A proud colleague of ourinstitute has been awarded the Nobel Prize. Congratulations Ben!.
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Congratulations, Pan Gao! "Direct arylation of alkyl fluorides using in situ mechanochemically generated calcium-based heavy Grignard reagents" has been published in RSC Mechanochemistry!.@haj19932469,@ICReDDconnect,@Mechanochem
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I hosted the Hokkaido International Workshop on Mechanochemistry, held on September 28-29, 2024, which concluded successfully. I had the opportunity to engage in intense discussions with many experts in mechanochemical synthesis!.
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異分野の先生に教えてもらった。Google が機械学習で、分子の物性を予測下論文を去年発表。精度もDFTと遜色ないとのこと。１３万個の分子に対するDFT計算ライブラリがあって、それを活用しているとのこと。知らないことばかり。.
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Our latest paper for Photoluminescent Ferroelastic Crystal has been accepted by Angewandte Chem. Congrats! Feng Chi and Dr. Seki. This is the first collaboration paper with the Takamizawa group!.
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Takumi's paper on the synthesis of hydrosilylborane has been published in ChemSci! Congratulations!.
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Mechanochem can be an useful tool for tackling insoluble material synthsis. Congraturations, Koji and Kondo-kun!.
In our recent @RSCAdvances paper, we demonstrate the potential of mechanochemical synthesis for efficient organic transformations of insoluble substrates into insoluble products. Congratulations to the team! @haj19932469
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Cograturations, Shizukuishi and Koji!.Solid-state nickel(0)-mediated Yamamoto coupling enabled by mechanochemistry.
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Big earthquake last night Japan. I am OK, but Tohoku was affected.
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Our new Chem. Sci. paper for mechanochemistry on the web!Congratulations Rina and Dr. Koji Kubota!
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Tokyo 2020 Olympics Marathon course will pass through our campus tomorrow!
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We organized a lecture by Prof. Dr. C. Malla Reddy from IIT Hyderabad, India, on the latest research in molecular crystals. The lecture was super hot for us, but he said that his visit to Sapporo at -4 degree C was the coldest experience of his life! @cmallareddy, @ICReDDconnect
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Happy New Year! We enjoyed a traditional Japanese dish for New Year
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Our new paper for mechanochemical Suzuki-coupling for solid substrates is published to Chem Sci. Tamae-san and Dr. Kubota, Congratulations! .
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Thank you for introducing the structure of our compound. The mechano-cross coupling method is a wormhole into a new chemical space!.
Four Japanese scientists have developed a rapid, solvent-free protocol for Suzuki-Miyaura cross-coupling reaction of insoluble aryl halides which opens exciting new areas in chemical space. #FeaturedStructureFriday CSD Entry: EQOPIM, shows red emission.
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TV news for the previous mechanoredox paper. (sorry, .Japanese only). @ICReDDconnect #mechanochemistry.
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Are you interested in the fundamentals, applications and future of #Mechanochemistry? Join me at this upcoming @RoySocChem @Faraday_D. Find out more: Early bird deadline: 25 July. #FDMechano #FaradayDiscussions.
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Our "Sweet Burch" paper has been highlighted in Chemisty World!.Sodium lumps, glucose and mechanochemistry behind ammonia-free Birch reduction:
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I had talks in Leeds U (BCA), NewCastle U and Birmingham! I appreciate kind arrangements of Erli, Thomas, Debbie, and Tomislav!
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Our mechanochemistry paper was featured on TV (in Japanese). I am talking in the laboratory.
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Congratulations! Koji, Daiyo, Takumi, Shun! Our latest paper just came out in ACS Catalysis! @ICReDDconnect,@k0j1chem.Synthesis of Chiral α-Amino Tertiary Boronates via the Catalytic Enantioselective Nucleophilic Borylation of Dialkyl Ketimines
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