Schroeder Research Group
@group_schroeder
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Small Molecules etc.
BTI and Department of Chemistry and Chemical Biology, Cornell University
Joined July 2019
Congratulations to Tae, Arif, and Chris on publication of their Nature paper, reporting a new class of bile acids that regulate cholesterol metabolism:
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@elonmusk This means: indirect costs at TESLA are at 100% of direct costs. If 60% is a ripoff, what is it that TESLA is doing?
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Our start-up Ascribe Bio announces investment by ICIG Ventures:
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@Nature It's really a rheostat - if the microbiota produce too much bile acids, which could perturb cholesterol metabolism, the body pushes back by converting the microbiota-derived bile acids into derivatives with the opposite activity.
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C. elegans as a model for how host-microbe interactions rewire conserved amino acid metabolism: Yong-Uk's paper from Marian Walhout's lab:
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Bingsen's perspective on how metabolic state feeds back on protein function and physiology: "Mechanisms of metabolism-coupled protein modifications" at Nature Chemical Biology:
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Next up: our PODCAST on how host-microbe interactions regulate fat metabolism in C. elegans: discussing our recent paper in Nature Communications:
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Must listen of the week: The Ascaroside Signaling PODCAST! Everything you always wanted to know about ascaroside signaling, dauer, MOGLs, and modular assembly: More entertaining than "This American Life", but generated with NotebookLM!
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Holoclara announced their Series A! Founded by Andrea Choe, Paul Sternberg, and Frank Schroeder, is a great success story, nicely summarized here:
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Cross-phylum detection of small-molecule signatures: Ping Hsueh's lab reports the identification of a fungal GPCR sensing nematode pheromones (ascarosides), see Nature Mircrobiology:
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Microbiota regulate conserved lipid metabolism via nuclear receptor signaling: see Bennett's paper "Evolutionarily related host and microbial pathways regulate fat desaturation in C. elegans" just published at Nature Commun.:
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Protein function is coupled to distinct branches of fatty acid metabolism - see Bingsen's PNAS paper "Amino acid- and protein-specificity of protein fatty acylation in C. elegans" just published at
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RT @BingsenZhang: A nice summary and comments on our acylspermidine story ‘The buck stops with spermidine | Nature Chemical Biology’ https:…
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"The buck stops with spermidine" - excellent News&Views piece on our acylspermidine paper by Anthony Michael:
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Microbiota-derived vitamin B12 reduces cholinergic signalling in the nervous system - see Wookyu's paper out at Nature Cell Biology today.
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