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Mike White

@genologos

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Associate Prof. of Genetics at Washington University in St. Louis. Blogging at https://t.co/YNgwcgywt0.

St. Louis, MO USA
Joined October 2011
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@genologos
Mike White
1 month
Deep learning with data beyond the genome: Our paper on active machine learning to model regulatory DNA is out today in Cell Systems. With functional assays and DNA synthesis you can generate any training examples, not just genomic sequences. 🧵
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@genologos
Mike White
13 hours
@BrandonWarmke Yeah the scientific community should make it clear that loudmouth radicals like this guy don't speak for the rest of us. Fuentes seems to embrace the opposite of every value that makes science effective.
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@genologos
Mike White
16 hours
What are the returns on R&D? Matt Clancy has a fantastic piece that he continues to update with the latest research:
@genologos
Mike White
16 hours
Sustained technological progress is the ultimate driver of sustained economic growth. Since the late 19th C, most technological progress is deeply rooted in advances in science. Most important technologies today are based on a deep knowledge of how the world works. The US…
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@genologos
Mike White
16 hours
@srikosuri I’m am so sorry to hear that your daughter is facing this. I hope you find the help you need.
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@genologos
Mike White
16 hours
And two more good links with citations to the broader literature:
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@genologos
Mike White
17 hours
RT @benryanwriter: 100% of the time, when someone says that a university has a big endowment and should spend more of it, they don’t know t…
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@genologos
Mike White
2 days
Elon is apparently bad at math:
@minilek
Jelani Nelson
2 days
Incorrect calculation. 60% indirect cost rate means for every dollar charged to the grant for the project, the university charges an *additional* 60 cents as overhead. So it’s 60/160 ~37.5% overhead, not 60%. The research has to happen somewhere — this pays for e.g. facilities.
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@genologos
Mike White
2 days
RT @ashishkjha: This is a very odd tweet and super disappointing to see from the esteemed @NIH The top 7 university recipients of nih fund…
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@genologos
Mike White
2 days
I completely agree with this take:
@mbeisen
Michael Eisen
2 days
The indiscriminate and ill-conceived slashing of indirects by the @NIH yesterday must be amended if want to restore America’s leadership role biomedical research. 15% simply isn’t enough for institutions to provide the basic infrastructure needed to run a successful lab. I say this as someone who has been and remains deeply critical of the NIH, its funding system and of the ways universities are structured and spend money. We would all benefit from a genuine reexamination of how and to what @NIH funds are allocated, and I remain optimistic that once the dust settles and new NIH leadership is in place that this is what will happen and this hack job by people who don’t understand or care about research will be forgotten. And I’m sorry but I can’t help but laugh at the people who are demanding a full-throated defense of the current indirect levels. Nearly every PI I’ve known for my entire career has complained about excessive indirect rates. This is mostly because, despite their importance, even most PIs haven’t bothered to actually understand them, and because they don’t FEEL that universities are actually spending the money to support their research. Whether they are or not nobody really knows because in the typically Byzantine maze of university budgets it’s often very hard to figure out. There are also lots of actual shenanigans that go on especially at places with the highest indirect rates to use funds to build out the institution and increase its power rather than to directly support funded research projects. And anyone who says administrative bloat at universities isn’t real and partially fueled by indirects is either blind or part of the bloat. So let’s get organized to have an actual constructive response to this firebomb. Scientists need to advocate for what is best for research - and we have to do it ourselves because the institutions that claim to represent us - universities and scientific societies in particular - have their own goals that often do not align with ours. We also have to remember that grants are not an entitlement. We are not owed anything. If we want to continue benefiting from the public support we have always enjoyed, we have to show the public and their representatives - even ones we might not always agree with - that we’re spending their money wisely.
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@genologos
Mike White
3 days
RT @genologos: @CorboLab Also, we’ve see this movie before. The sequel might be different but these guys will still have a tough time makin…
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@genologos
Mike White
3 days
@CorboLab Also, we’ve see this movie before. The sequel might be different but these guys will still have a tough time making it stick:
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@genologos
Mike White
3 days
On the NIH indirect rate cut, some law firms have been anticipating this:
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@genologos
Mike White
3 days
@CorboLab Maybe, but this change was laid out in Project 2025 so someone has been planning it for awhile.
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@genologos
Mike White
3 days
@SashaGusevPosts Yeah right now my priors are that most of this doesn’t last very long. Not that it will be optimal after that but these guys are going pedal to the metal towards the wall of court injunctions and the Congressional budget negotiations. But I am often wrong.
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