Excited to share 2p-prime, a novel physical pathway for multiphoton fluorescence generation that enables optical sectioning and excitation at red wavelengths with simple systems like continuous wave lasers. I founded @tripletimaging with @jdwong_campos to fully realize the potential of this tech and introduce a new paradigm for multiphoton fluorescence. We’re exciting real intermediary states, specifically driving forbidden triplet transitions, using picosecond and continuous wave lasers. Links to two pre-prints + explanation in the thread where we demonstrate 2p-prime with ps and CW lasers in dyes and living cells expressing fluorescent proteins. David thought of this idea, inspired by optical control of forbidden state transitions in atomic systems from his past life in quantum computing in the Monroe lab and as an early employee at @IonQ_Inc. In the limit, our approach could be optimized to replace all fluorescence microscopes with simple LED systems that can do rapid volumetric imaging with capabilities akin to existing 2p systems in optical sectioning, contrast, depth, and resolution. Low power, high throughput multiphoton imaging could enable moonshots like functional imaging of every synapse on a neuron or single cell resolution across an entire mouse cortex — datasets which are inaccessible now due to high powers required by ultrafast lasers. Fundamental insights may generate broad possibilities, and we’re investigating applications across multiple industries like diagnostics and 2p lithography. This is a white space in photophysics. No indicators have been designed or evolved for this process. We’re optimistic we’ll keep lowering power levels as indicators are optimized for these transitions, e.g. enhanced spin-orbit coupling.

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We’re excited to introduce @ChaiDiscovery and release Chai-1, a foundation model for molecular structure prediction that performs at the state-of-the-art across a variety of drug discovery tasks We're releasing inference code, weights & a web interface: