Elmir Omerovic
@elmir1omerovic
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Cardiologist and researcher. Enjoys debates ("battle of ideas") on most topics with mutual respect. Believes Sweden is one of the best societies in the world.
Göteborg
Joined December 2016
Recently, we gathered our research group, with my previous mentors Åke Hjalmarson (in front of me) and Finn Waagstein (to my left). Both of whom were my PhD mentors 25 years ago. Pioneers who reshaped cardiovascular medicine from Gothenburg to the world, their courage to
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In healthcare and research, efficiency, precision, and measurable outcomes are rightly prized. But there are always colleagues who think more broadly, ask the uncomfortable “why” before the “how,” and reflect on meaning as much as on metrics. In Sweden, such colleagues are often
linkedin.com
In hospitals and research groups worldwide, colleagues who think broadly, ask big questions, and reflect on meaning rather than only on metrics are sometimes labeled with the Swedish word "flummig"....
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That hierarchy putting RCTs at the top and expert opinion at the bottom? It might be broken. Chris Blunt's research reveals there are DOZENS of conflicting pyramids, and they're turning complex medical decisions into checkbox exercises. We've traded authority-based bias for
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A Sacred Symbol Under Scrutiny For more than two decades, a familiar icon has sat atop the altar of medical rationality: the evidence hierarchy pyramid. Clinicians are taught to climb it.
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A broken heart can physically break your heart—and it happens almost exclusively to women. Takotsubo syndrome isn't a rare disease; it's proof that our medical knowledge is incomplete. Read on to see how this mysterious condition exposes thousands of years of gender bias in
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It often begins suddenly: a patient arrives with severe chest pain following an intense emotional or physical shock — the death of a spouse, a devastating diagnosis, a violent argument. The ECG is...
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@"Challenging the Gold Standard: Major Critiques of Evidence Hierarchies" https://t.co/gcTAldwtoy on @LinkedIn
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The dominance of randomized controlled trials (RCTs) as the "gold standard" in medicine faces substantial criticism from Nobel laureates, prominent medical researchers, philosophers of science, and...
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The greatest scientific breakthroughs didn't come from following the rulebook—they came from rewriting it. From telescopes that challenged Church doctrine to preprint servers that bypassed peer review during the COVID-19 pandemic, science advances when rebels dare to ask: 'What
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The Dual Nature of Scientific Method Scientific methodology serves essential functions in the production of knowledge. Standardized approaches, such as randomized controlled trials (RCTs) in medici...
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A veteran critical care physician @PatientStormDoc presents a plausible and thought-provoking thesis: medical research has become monopolized by small groups creating "pathological consensus," which may explain why promising treatments fail in trials and breakthroughs take
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Can results from RCTs and observational trials addressing the same hypothesis be true simultaneously? This question, inspired by Nancy Cartwright’s work on "different causal environments" and potentially missing or differently functioning causal links, is intriguing.
Can administrative real-world data substitute for RCTs and offer propensity matching to reduce bias? Results often fail to correspond & @LGHemkens et al study showed direction of effect differed in 31% & CI failed to include RCT estimate in 56% https://t.co/aaQUuW2p6z
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Takotsubo Syndrome: From Bench to Bedside – Advancing Research and Patient Care https://t.co/puD0R2zyap I'm honored to serve as the special issue editor for Reviews in Cardiovascular Medicine on the topic of Takotsubo Syndrome. This special issue aims to advance our
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Beyond the Gold Standard: Can Observational Studies Establish Causality?
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John Mandrola's (a cardiac electrophysiologist and prominent healthcare writer) recent article, reflecting on the 10th anniversary of the Learning Early About Peanut Allergy (LEAP) trial, has made me...
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Check out my latest article: Dags att ta fas-4 studier på allvar – evidens efter marknadsföring behövs för en effektivare vård! https://t.co/WKlQZi1gui via @LinkedIn
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Vi befinner oss i en tid då medicinska innovationer accelererar. Nya läkemedel, devices, avancerad bilddiagnostik och digitala beslutsstöd lanseras snabbare än någonsin.
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Check out my latest article: The Social Construction of Medicine: Navigating Profit and Public Health https://t.co/hgi8feF1OU via @LinkedIn
linkedin.com
In the gleaming corridors of modern medical facilities, surrounded by state-of-the-art imaging equipment and pharmaceutical innovations, we rarely pause to consider a fundamental question: How much...
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Check out my latest article: When Statistical Elegance Meets Clinical Reality: A Cautionary Tale https://t.co/TtxpCSpGga via @LinkedIn
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We live in an era where clinical research increasingly chases statistical shortcuts over meaningful evidence. Novel methodologies promise to extract more signal from smaller datasets, include more...
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Win Ratio: A Seductive But Potentially Misleading Method for Evaluating Evidence from Clinical Trials | Circulation https://t.co/yeBfq3Iv6b This thought-provoking paper critiques the win ratio in a convincingly articulated manner. I'm curious whether the Bayesian approach with
ahajournals.org
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@"When "Similar Results" Don't Mean Similar Theories: The Frequentist vs. Bayesian Debate" https://t.co/OJYUiP2ZK5 on @LinkedIn
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I recently debated a colleague who argued that frequentist and Bayesian statistics are "essentially equivalent" because they often reach the same conclusions in well-executed studies. This reasoning...
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@elmir1omerovic Bayes is fundamentally different here because one study can simultaneously serve multiple purposes with Bayes: efficacy, non-trivial efficacy, inefficacy, non-inferiority, similarity:
hbiostat.org
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Why the Way We Analyze Clinical Trials May Be Flawed—and What Bayesian Thinking Offers Instead
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By Elmir Omerovic, MD, PhD, FESC, FHFA, Chair Professor of Cardiology, Sahlgrenska University Hospital Inspired by Donald A. Berry’s “Interim Analysis in Clinical Trials: The Role of the Likelihood...
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