Michael Marks
@dr_michaelmarks
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Professor of Medicine @LSHTM | Consultant in Infection @HTropDis | #NTDs #STIs #StrepA #Trials | Roles @STIRIG_LSHTM @PHOSP_COVID @snap_trial @ControlScabies
Joined June 2016
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Persistent shedding
#COVID19
once asymptomatic
@JAMA_current
Implications how long home-managed patients should self-isolate
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Honoured to be awarded the Frederick Murgatroyd prize by
@RCPLondon
for my work on tropical medicine. This is result of collaborations with colleagues in Solomon Islands, Papua New Guinea, Ghana, Cote d'Ivoire, Liberia, Cameroon & Ethiopia to whom I am eternally grateful
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Ending year on a high. Delighted to be appointed Professor of Medicine
@LSHTM
Would not have been possible without a long list of collaborators, supporters, friends & colleagues in UK & overseas. Enormously grateful to you all but especially to
@SarahVMarks
for unwavering support
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Chloroquine
#COVID19
trial stopped early: increased mortality high-dose arm
@JAMA_current
High rates QTc prolongation
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Phenomenal
@DNDi
Acoziborole is effective single dose Rx for West African Trypanosomiasis. Definition of game changing
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Clever study
@JAMAInternalMed
2 weeks post birthday = increase
#COVID19
cases. Shows impact social gatherings have on risk
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Signing off after 3 Night Shifts for team Acute Medicine
@uclh
Grateful to all my colleagues who helped us continue to deliver safe high quality care. Experience a reminder of how much we rely on junior doctors & importance of ensuring their critical role is adequately recognised
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I like ivermectin. I've given 25,000+ people it in trials. But completely unsurprised doesn't work for
#COVID19
@JAMA_current
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Our data
#COVID19
@TheLancetInfDis
Viral load major driver transmission & risk & timing onset symptoms
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Amazing
@SMHopkins
Fantastic see data showing vaccination reduces risk ANY
#COVID19
infection not just symptomatic disease
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David Mabey officially retires
@LSHTM
today after a 40+ year career dedicated to improving health & wellbeing globally. It has been a huge privilege for myself & colleagues to have worked with him. Sadness but also pride at the immense impact David has had worldwide. Thank you.
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Delighted one of my heroes
@rashida_abbferr
has been awarded the Donald Mackay medal by
@RSTMH
&
@ASTMH
Role model, mentor, superstar, friend
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Delighted appointed
@HTropDis
today alongside
@LSHTM
thank you all colleagues 10+yes training but esp
@SarahVMarks
supporting me all the way
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Super excited welcome
@GumbieAnne
@LSHTM
First nurse appointed to our
@wellcometrust
@CreatePhd
scheme. She's going to rock it in Zimbabwe!
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Delighted appointed Honorary Associate Professor
@UCLInfectImm
alongside role
@HTropDis
Thanks esp
@RHeyderman
&
@ecmorris
supporting!
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12 months after hospitalisation w
#COVID19
many patients still not back to baseline: results
@PHOSP_COVID
@LancetRespirMed
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Preprint
#COVID19
human challenge model out! Loads unpick on viral kinetics & host response. Incredible work
@ChrisChiuLab
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Vitamin D doesn't prevent TB
@NEJM
Vitamin D now failed trials ICU Cancer heart disease diabetes TB. It's time to move on
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Incredibly useful genomic epidemiology
#COVID19
UK >1300 separate importation events. Interesting France & Spain both > Italy
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Delighted
@mwelentuli
named in most influential African women To be honest one most influential women globally Her leadership transformative
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Fantastic to have
@SoceFallBirima
new
@WHO
Director for
#NTDs
visit us
@LSHTM
. An opportunity to meet with David Mabey current chair of STAG & discuss how we can accelerate progress together towards 2030
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#ECCMID2024
Sort of impressed I have made it to Day 3 of the conference before I have felt the need to re-post this conference staple
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Lengthy (13 page)
@JAMA_current
review Rx
#COVID19
..... My version would be very short "Much hype, no data, trials needed"
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Amazing team
#RECOVERY
trial
@PeterHorby
@MartinLandray
demonstrating Dexamethasone first drug reduce mortality
#COVID19
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Delighted to say I'll be giving a keynote
@IUSTI_World
2024. There has been a global resurgence of syphilis & the burden of congenital syphilis remains unacceptable. I'll be discussing major challenges facing syphilis control worldwide & new tools & approaches to tackling this.
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Next week kick off NTD module
@LSHTM
If anyone can beat our combo of
@PeterHotez
@mwelentuli
as opening & closing speakers I'll be impressed
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Oral switch non-inferior for treating Gram Negative Bacteraemia
#ECCMID2023
with lower length of stay. Once again oral for the win. Not surprised by result but I guess we hope this can convince anyone still stuck using IV.....
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"If you ask why we have not yet eliminated NTDs it is because we have not yet eliminated poverty"
@anthonywsolomon
@EDCTP
#edctpforum
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🚩📕Do you see the ulcers caused by
#syphilis
?
💡For the first time we open the door to treat syphilis with five oral tablets of the antibiotic
#linezolid
.
Take note of a great discovery that can change the live of many people.
#MSM
#STI
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Are you a UK registered nurse, biomedical scientist or pharmacist interested in a PhD? We have opportunities to apply for a Global Health PhD focused on Group A Strep in the Gambia & would love to speak to you & support your application! DM/Email me if interested
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Many congrats
@ankurgw
on Woodruff Medal PhD
@LSHTM
LAMP reduce TB deaths: Results
@TheLancet
Steve Lawn would be very proud
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How do self collected swabs for
#Monkeypox
perform? Our preprint says well! Opens door to remote monitoring inc. in trials
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Delighted UK officially joining
@snap_trial
under leadership Anna Goodman
@MRCCTU
&
@GSTTnhs
with funding from
@NIHRresearch
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Reasons for these huge variations vaccine rates undoubtedly complex. Not in doubt is need address them or we perpetuate health inequalities
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Excited announce
@gatesfoundation
grant on Genital Ulcers &
#Syphilis
genomics with crack team in Ghana Uganda Botswana Zimbabwe & Argentina
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Great Mendelian Randomisation study VitD not actually associated
#COVID19
& if anything high VitD bad Quelle surprise
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Unsurprisingly Omicron was in 10+ countries before
@Tuliodna
& teams &Botswana 1st identified. Vaccine equity not travel bans please
Looking at GISAID, global surveillance data, Omicron was first detected in a specimen from Italy and was widely circulating prior to South Africa's first report November 23rd. That's why travel bans do not work, never will
@LawrenceGostin
@MonicaGandhi9
@CarlosdelRio7
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Heartbroken beyond words at the passing of Mwele Malecela. Had privilege to work with her to help tackle NTDs. Her warmth, passion, intelligence and integrity will remain an inspiration to me for the rest of my career.
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Valuable analysis
@MRC_Outbreak
#COVID19
Isolation&quarantine big impact. Social distancing 70+ impact due severity this age
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Our new paper
@medrxivpreprint
extends our previous work & quantifies risk
#COVID19
in relation to estimated peak viral load
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Remdesivir is a good drug for
#COVID19
if given very early. This Kaplan Meier is dedicated to
@FranciscoMarty_
#RIP
Among nonhospitalized patients with Covid-19–related symptoms, a 3-day course of remdesivir resulted in an 87% lower risk of hospitalization or death than placebo.
#COVID19
#IDTwitter
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25%+ ICU
#COVID19
patients imaging confirmed VTE despite prophylaxis Trials on this at least as urgent as antivirals
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#Influenza
is associated with a significant impact outside of the respiratory system including a marked increased cardiovascular risk
#ECCMID2023
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Excited that we are now open for recruitment into the
@CureTrep
trial
@MMC_cnwl
- evaluating Linezolid as a fully-oral treatment option for patients with early syphilis. Thanks to
@oriolmitja
for inviting UK sites to join &
@UCL_CRISH
for helping us get off the ground!
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Important data Ertapenem viable option
#Gonorrhea
but fact we need carbapenems for GC it shows how close we are to an untreatable organism
New from
@TheLancetInfDis
Efficacy of ertapenem, gentamicin, fosfomycin, and ceftriaxone for the treatment of anogenital gonorrhoea (NABOGO): a randomised, non-inferiority trial by
@henryjdevries
and colleagues
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Latest estimate
#COVID19
R0 UK below 1
@MRC_Outbreak
Need keep down until outbreak over & have tools respond to any 2nd wave
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Can we accurately cohort patients before PCR for
#COVID19
& protect side rooms. Our data
@HTropDis
says yes
@medrxivpreprint
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This was the slide for me from
@KatharinaKranz4
inaugural lecture
@LSHTM
- collaboration as the mechanism to expand both breadth & depth of research. Wonderful & inspiring.
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