Greg Bowman
@drGregBowman
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Imperfect Christ-follower desperately searching for truth, especially through science. Prof @Penn. Director @foldingathome. Legally blind. Father
Philadelphia, PA
Joined March 2013
I've moved to the wild blue yonder🦋.Same handle as this platform.
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As promised, here is our first glimpse of the #COVID19 spike protein (aka the demogorgon) in action, courtesy of @foldingathome . More to come!
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Great progress capturing how the ferocious #COVID19 #Demogorgon (aka spike) opens its mouth to grab its human prey. Each step could present new therapeutic opportunities. Thanks to @foldingathome @Microsoft @Azure #AIforHealth @Mizimmer90!
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A senior administrator told me to my face that I don't add to diversity because I'm a white male. Funny, because I only know one other blind scientist with a faculty position. Can we please expand notions of diversity beyond what is easily visible? For now, I ordered a blind cane.
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Amazing! @foldingathome now has over 470 petaFLOPS of compute power. To put that in perspective, that's more than 2x the peak performance of the Summit super computer!.
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Notice your @foldingathome installation is idle? So many people have joined in to support our work on #COVID19 that our servers are struggling to keep up. We're continuing to get more online as quickly as we can. We still need your help, so please be patient with us. Please RT.
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🚨The BIG News🚨.Delighted to share that the Bowman lab will move to @Penn this summer, where I will serve as a Penn Integrates Knowledge (PIK) Professor with a joint appointment in the Perelman School of Medicine and the School of Engineering! @BB_UPenn @pennbioeng
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There are now over 1M devices running @foldingathome ! This includes over 356K @nvidia GPUs, over 79K @AMD GPUs, and over 593K CPUs! Thanks to all our volunteers! We're planning more blog posts on our #COVID19 work/results this week, please stay tuned.
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🚨#COVID19 PAPER ALERT🚨. The BIG one from @foldingathome. World's first #exascale computer. Dramatic spike opening provides insight into why #SARSCoV2 is worse than other #coronaviruses. Cryptic drug targets across the proteome.
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I wonder how many women would NOT have endured sexual harassment if universities actually held people accountable for inappropriate behavior that wasn't technically illegal. As is, they let people flirt with that line until (shocker) someone crosses it. Ahem, @WUSTLmed.
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Finally got to see all our new @foldingathome hardware!.1.5 *PB* @PureStorage FlashBlade.48 @AMD MI-50 GPUs.24 @AMD 64-Core 7742 2.25GHz CPUs.🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥🔥
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@ProfessorAntony @WUSTLmed I've uncovered six separate instances of sexual harassment in the past 7 years, filed 2 Title IX cases on behalf of students, vocally denounced numerous other lesser forms of abuse, and can't get anything done. Thus, I went on the job market and am leaving, in complete disgust.
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I've been legally blind for the past 25 years. Last week, I think we finally found the mutation responsible for my vision loss.
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Thanks @jonykipnis for course correcting in response to data! All, please join me in extending grace to Jony. He and I are now working together to encourage @WUSTLmed, @WUSTLdbbs, and @BBSBwustl to make immediate course corrections of their own.
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More GPU work units are coming for @foldingathome. We've had to shift some of our effort from setting up projects to moving data off servers to make room for more data. Its amazing how quickly the data is coming in! Something like 6TB/hr.
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For me, the worst part of being #disabled is the drain on my ego. Its incredibly hard to maintain a sense of self-worth and confidence when you are literally constantly thwarted by simple tasks that almost everyone else does with ease, compounded by the social isolation. 1/8.
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Welcome to Anne, the newest member of our rapidly growing Bowman lab!
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Amazing! Over 400K people have downloaded @foldingathome in the past two weeks to help with #COVID19 research. That's about a 10x increase in volunteers. Thanks all!.
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🚨PAPER ALERT🚨.Introducing PocketMiner, a fast, accurate tool for predicting the locations of cryptic pockets from single protein structures. PocketMiner is a graph neural network whose speed enables proteome-wide predictions. #compchem #DeepLearning .
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@Brcremer Seriously. These people could at least have some internal consistency and apply Biblical principles for choosing leaders. 1 Timothy 3:2-3 Now the overseer is to be above reproach, faithful to his wife, temperate, self-controlled, respectable, hospitable, able to teach, not given.
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@jonykipnis Disagree. For example, I haven’t felt safe speaking up publicly until having a way out. Love lots of people at @WUSTLmed but it’s ridiculous how impossible it is to do basic things like protect students from abuse. Want to talk privately?.
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We are getting more servers and simulations going for @foldingathome as I type! More #COVID19 simulations coming ASAP.
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Delighted to announce that I've launched a company, Decrypt Bio! My co-founder, the rest of the team, and I are combining simulations and experiments to drug cryptic pockets. You can learn more at our avant-garde website😀.
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.@foldingathome has surpassed an exaFLOP, making it the first to reach the exascale! You can read more at.
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This is amazing! So many have joined @foldingathome that all our simulations are assigned. We're working as fast as we can to get more going. There is still lots of useful science to be done, so please be patient with us.
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We've nearly double the number of active servers for @foldingathome in response to jumping from 30K volunteers in Feb to >400K in mid march. This helped a lot with reducing idle time, and then 300K more volunteers joined! Great news, and we're working on even more servers.
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Great video on how to run @foldingathome on your computer to help research #COVID19. First part is assembling awesome hardware, then how to use the software. Thanks to our friends @LinusTech @jakkuh_t .
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Thanks @CoreWeave for your trail-blazing contribution of 6K GPUs to @foldingathome and our work on #COVID19 ! Its a great example, and we're excited to see others joining in too!.
CoreWeave has donated 6000 GPUs to Coronavirus (Covid-19) check out the most recent article on CoinDesk now!.
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We are thrilled to share that primary faculty member @drGregBowman has been named a Penn Integrates Knowledge (PIK) Professor! Read more here:
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I'm very pleased to share that I was just awarded tenure @WUSTLmed. Thanks to all my family, lab, mentors, colleagues, friends, and letter writers!.
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I think that makes @foldingathome the largest super computer in the world, and we're trying to bring the whole thing to bear on #Covid_19. We can't guarantee what the results will be but man is this a cool opportunity!.
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My parents just declared themselves anti-vaxxers. And this after having been so proud of everything I helped do with @foldingathome and #COVID19 research. I hate the "news" outlets that have filled their heads with lies. I'll be in the corner weeping if anyone needs me.
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We have released a new version of the @foldingathome software with the option to prioritize #COVID19 projects. More details at Available for download now at
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Our first paper on #COVID19 is a major milestone for @foldingathome. So proud of my research team and our collaborators for all the great work, and so grateful to our volunteers and supporters for enabling a mind-blowing scale of computation!.
🚨#COVID19 PAPER ALERT🚨.With your help, F@h became the first #exascale computer, collected 100,000X more data than a normal paper, learned how the #Demogorgon evades our immune system, and discovered drug targets called ‘cryptic’ pockets (#FAHPockets)!.
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Ever wonder if kinetics are really important, or if you just need thermodynamics?. Here's a great example of where kinetics are key!. We show that accounting for dynamics that occur during single molecule FRET experiments (which we call time-averaging) is often critical for
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First official day as @Penn faculty! Celebrating with the advanced party of the Bowman Lab🍾🎉🎉🎉
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Got a new magnifying device to help cope with my vision loss. 5yo wanted to help assemble it, so I asked her to write me a note to test whether I could read it with my new machine. Here it is🥰🥰🥰🥰
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Thanks to everyone who engaged with my tweets about #SexualHarassment, abusive behavior, and the lack of accountability at @WUSTLmed. Together, we spurred more serious discussion about making change than I have witnessed in the past 8 years! I'll keep you posted where things go.
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.@foldingathome has launched projects to screen for small molecules that target the #COVID19 main protease. The results will help prioritize compounds for experimental testing by our collaborators. Read more at @voelzlab @jchodera.
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#phdadvice.Start drafting papers long before you have "all" the data. Brainstorming on titles, section headings, and figures is a powerful way to find the best story and prioritize the data/analysis that are most important to solidifying the story or informing a course correction.
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We are continuing to setup @foldingathome servers as fast as possible. Welcome to our newest machine, a @CiscoDC UCS Server provided by @CiscoCanada Toronto Co-Innovation Centre #TOInnovate setup by @cantechit with a 1Gbe Fiber Connection courtesy of @beanfield Metroconnect.
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Wait @jonykipnis, did you reach out to me before denouncing me on Twitter? No. In contrast, I have given every relevant party @WUSTLmed SEVEN YEARS of chances before going public. A private email would have been a better way to setup a chat.
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Please be patient if you experience idle time on @foldingathome as we face the #COVID19 pandemic together! We are working like mad to start simulations of COVID-19 proteins. The enthusiastic response to our effort has been tremendous and has sometimes emptied our queues.
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What are the chances? @bowman_rl and I.- are visually impaired scientists.- share same last name.- just started faculty positions @Penn.- have labs across the street from each other.- live two blocks away from each other.- have daughters who will start in same kindergarten.
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Teared up in my office this morning for JOY! My parents finally snapped, in a good way, and apologized for all the lies and terribleness! I thought they were gone forever, and now there's hope that I get them back! And maybe, just maybe, America can heal too. .
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Behold, the #COVID19 #demogorgon (aka #SARSCoV2 #spike) in 3D👾 This dramatically open structure was discovered using computer simulations conducted on @foldingathome and predicts 'cryptic' epitopes where therapeutic antibodies can bind that were later confirmed experimentally
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I mostly tweet to share the wonders of science, and avoid politics to maximize my audience. But when an administration with a history of attacking science broadens its attack to target democracy, hell yea I'm getting political! #RemoveTrumpNow.
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We at @foldingathome are excited to partner with @Microsoft #AIforHealth to tackle #COVID19! I've always wanted @foldingathome to be running on every continent and am excited that @Azure now has us running in undersea data centers too! Space station next?.
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One of my childhood dreams was to have the most powerful computer, as captured by this attempt at art that my parents found in their basement archive. Now I have the privilege of leading @foldingathome!
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What a spectacular week!.#COVID19 @foldingathome paper in @NatureChemistry.#DeepLearning paper in @NatureComms.New grant from @NIH.@justin_j_miller got a postdoc fellowship.@CatieKnoverek got good reviews on a manuscript.and so much good data from the rest of the lab!.
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@ProfessorAntony @WUSTLmed Thanks. For starters, maybe the graduate program leaders should reallocate time from virtue signaling to actually taking accusations of misconduct seriously. And junior faculty should never be told to drop issues because it could impact their tenure process. Will stop there.
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Good bye Saint Louis. You've been a great place to live! I will miss the convenience of having everything within a 15 min drive, the beautiful brick homes, the zoo, forest park, and so much more.
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I got my first R01 #grant as a mid career investigator without ESI status! #AcademicTwitter #AcademicChatter
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For all the students/postdocs who are weighing academia versus industry, consider that the reason you see way more complaining about academia online is that you are allowed to complain online. Lawyers may call you when you complain about companies.
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If you had $500M to create an opensource dataset to drive drug discovery, what data would you want?.
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Awesome video on @foldingathome and our work on #COVID19 at @FinancialTimes! Touched by the personal bit about @foldingathome satisfying my childhood dream to have the largest computer in the world. Thanks @tomhannen for the great work.
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Wow, one of our reviewers on a paper didn't ask for any changes! That hasn't happened to me since 2008. Party!🥳🎉🎉🎉.
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@Brcremer Thank you for speaking up on the important distinctions between God’s Word and what so many “Christian’s” are claiming.
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🚨PAPER ALERT🚨.Our paper on predicting the locations of cryptic pockets from single protein structures using deep learning is now live on @NatureComms website!.
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Just had a postdoc try to recruit me to their Profs lab at a graduate student recruiting event. A proud moment! Glad someone still thinks I loook younger than the mirror does.
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🚨PAPER ALERT🚨.Our first official #SARSCoV2/#COVID19 paper is out! Great collaboration with @alexholehouse's lab on the nucleocapsid protein's dynamics and phase separation with RNA.
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Woohoo! One house purchased in Philly, one house under contract in Saint Louis! Phew! Shouldn't have to live in a box or manage two mortgages.
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We’ve released a new version of the @foldingathome software (v7.6.13) that fixes issues reported with GPU utilization. You will likely get a warning when you try to install on @Windows, and we are working with@Microsoft to resolve this. Please upgrade at.
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Just had a zoom chat with a half dozen other scientists who have vision impairments like my own. Its amazing how refreshing it is to find people who can deeply relate with one's own life experiences!
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A little review I wrote is now live. AlphaFold and Protein Folding: Not Dead Yet! The Frontier Is Conformational Ensembles.
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Deeply honored to be part of the @Microsoft #MSBuild event. As Director of @foldingathome, I'm grateful to @Microsoft #AIforHealth, @Azure, and @satyanadella for all their support for our #COVID19 work and beyond! The commitment to empowering our community is amazing!.
Global organization @FoldingatHome is researching #COVID19 proteins that could help with designing therapeutics. This AI for Health grantee harnesses the collected power of millions of volunteers through Azure and GitHub. #MSBuild
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Awesome t-shirt campaign to help fund @foldingathome's work on #COVID19 from @LinusTech and @intel. Thanks for the support!.
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Delighted to share PopShift, a framework for doing drug design against maps of a protein's conformational space instead of a single structure. v1 uses docking against MSMs, and I joke I'm proud to have extracted some value from docking😜.
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Is it OK to celebrate #InaugurationDay with a glass of 25-year Highland Park #whisky in the middle of the day? Rhetorical question, cheers to #democracy and to everyone! #unity #BuildBackBetter
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.@foldingathome is continuing its growth spurt! There are now 3.5M devices participating, including 2.8M CPUs (19M cores!) and 700K GPUs.
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.@foldingathome stats update: We are prioritizing getting work servers and simulations up so we can make effective use of all this amazing compute! The stats website is down, but points are being recorded. We will shift our attention to fixing/updating stats shortly.
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In the coming month I get to celebrate 15 amazing years of marriage with @Angela_punnedit, 1 year living in Philly, and 1 year with all my great colleagues @Penn @BB_UPenn and @pennbioeng! I am one lucky guy!
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We got the first house we made an offer on in the #Philly area! Whew! It is such a relief to know we have a place to live. And that it is very nice and has good public schools.🎉🎉🎉.
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@foldingathome is taking up the fight against COVID-19 / 2019-nCoV. Kudos to @jchodera and his team for tackling this important problem!.
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Academic colleagues, what do you like about academia?. There's many problems in academia that are getting well-deserved attention on social media. But I'm guessing I'm not the only one who is still having fun😀 Here are some thoughts on what I like. #AcademicTwitter.
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Its been great getting to know my new colleagues @Penn! #BenFranklin even gave me helpful feedback on a manuscript! Though admittedly it was a bit of a hurdle to get it printed on parchment for him. 😀
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Presenting to 10,000 cancer researchers at #aacr23 is quite the experience! Here’s the view from the stage before they let the audience in
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We face many common enemies, including #SARSCoV2 / #COVID19 and #Alzheimers. Let’s join forces to tackle them! Whether on lockdown or not, you can always lend a hand from the comfort of your computer through @foldingathome.
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We solved our first x-ray crystal structure (PDB 6B2N), verifying one of our computational predictions about how mutations stabilize proteins. Pretty good for a "computational" group. Actually, half the lab is experimental.
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Beautiful figures have a lot more impact than you might think, even for an audience that prides itself on primarily caring about the data.
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🚨PAPER ALERT🚨.DiffNets is a powerful #deeplearning approach to identify the key features that distinguish two or more ensembles of protein structures. Great for comparing simulations of protein variants, apo vs holo states, parts of one simulation, etc.
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Here's an example of the sort of motion we're using @foldingathome to hunt for in #COVID19 proteins. It creates an unexpected binding site we're now trying to target with drugs. (example is from an Ebola protein, hope to have #COVID19 results to share soon)
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Sad to share that I have resigned from Decrypt Bio, the company that I co-founded. I learned a lot, made some great friends, and had a good deal of fun along the way. So why leave? Buy me a drink and we can chat. The better the drink, the more animated the epic story will be😀.
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On a lighter note, here is a brief statement from @foldingathome mission control on how we plan to tackle #COVID19 (please pardon the s**t word, folks here are a little amped up over the 60-fold growth in our user base this past month and the scientific insights it’s enabling!)
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@squatchknows @Brcremer I don’t have much material as I don’t recall them claiming to represent God or the church as a major theme of their campaigns, nor do I recall the church vocally claiming Clinton or Biden as its champion.
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Oh my God, I'm #vaccinated and at work! . Found a receipt on my desk from my last flight two weeks before lock down. #DejaVu . When you return to work, I recommend bringing a duster!
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French President Macron: “I no longer have any intention of sacrificing my life, my time, my freedom and the adolescence of my daughters, as well as their right to study properly, for those who refuse to be vaccinated. This time you stay at home, not us.”. Amen!.
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We discovered and experimentally verified a new cryptic pocket in beta-lactamase with greater potential to inhibit antibiotic resistance.
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Protein folding and related problems remain unsolved despite AlphaFold’s advance.
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We are officially Philly residents! Spent our first night in our new home after a busy day of signing many, many forms. The new adventure begins!.
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