Sarah Ross
@decouvriez
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Neuroscientist investigating the neural basis of pain and itch.
University of Pittsburgh
Joined January 2011
Beautiful work from @tayler_sheahan who starts her new faculty position at Medical College of Wisconsin on Tuesday. What a coup!
đĽłNew pub! Kappa opioid receptor agonists are clinically effective in treating chronic itch, but how do they work? We've found which neurons carry itch from the spinal cord to the brain and show kappa agonists inhibit these cells to suppress scratching đŚ
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This is a super paper! Congrats @InsanallyM
New paper out in @NatureComms! Combining in vivo cell-attached, extracellular, and whole-cell recordings during behavior with a spiking RNN we show how a diversity of neural response types contributes to network function and task performance.
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We are so glad @maliqa_m is coming to the Pitt Pain Center for grad school!
This is so sweet. Our lab is saying goodbye to an absolute rockstar of a pain scientist. She brought so much supportive and happy energy to our group and we are sad to see her go!!! Weâll miss you @Maliqa_M but we know youâre going on to do GREAT things. âđžâĽď¸
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RT @leonard_qi: Excited to share our paper on mouse DRG genetic toolkit that reveals morphological and physiological diversity of somatosenâŚ
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@DartmouthNeuro @dartmouth @GeiselMed @DartmouthHealth @MsbDartmouth @MCBDartmouth Thanks for inviting me! The Dartmouth Neuroscience community has a great vibe and is doing really exciting research.
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I love this videoâlook at how output neurons from the right spinal cord ascend in both the ispi and contralateral tracts, then cross over in the PBN. These ipsi projections may account for the pain that arises despite lesions of the contralateral ATL. Great work @HAICHAO48137354
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Very proud of @tayler_sheahan and @CharlesWarwick7 for their work showing that GRPR spinal output neurons convey itch from the spinal cord to the brain and that kappa opioid receptor agonists target these neurons to inhibit itch. So cool and satisfying!
â¨Excited to share some new work!â¨We studied the spinal coding of itch at the population level to ask 1) How are different itch stimuli encoded within the spinal cord? 2) Do clinically effective kappa agonists inhibit spinal neurons? (1/10)
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According to said book, James described this as âthe persuance of future ends and the choice of means for their attainmentâ, but Weiskrantz uses it to illustrate that subconscious circuits mediate seemingly willed behaviors so itâs hard to know which actions require consciousness
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RT @AdamHantman: @decouvriez 1840's discovery also see Fukson, Olga I;Â Berkinblit, Michael B;Â Feldman, Anatoly G, 1980
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@AdamHantman Yes, I should have clarified. An old discovery that I learned about recently in a book by Weiskrantz on consciousness (that did not cite original reference). Thanks for sharing!!! Very glad to have this.
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@geerling_lab My definition would likely be broader than most, including all DRG input that ascends in the ATL and all vagal+ afferent input that targets the NTSâtwo arms of a system that converges in the PBN and is represented in the insula. So lots of non-vitals like C-LTMR and taste too.
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