Charles Danko
@charlesdanko
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I study how genome sequence controls gene expression at Cornell.
Ithaca, NY
Joined January 2014
Pol II pausing is an important regulatory step in gene expression. Its present in most animals, but absent in yeast. How and when did pausing evolve? Check out our latest by @alexachivu.
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RT @missing_a_rib: Does training sequence-to-function models on matched functional & genome sequences improve variant effect prediction? Fo…
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Latest work from our lab on improving variant interpretation for sequence to function models. Congrats to @missing_a_rib and @NathanPalamutt3
Does training sequence-to-function models on matched functional & genome sequences improve variant effect prediction? For local functions like transcription initiation/enhancer activity, our view is yes. Please check out our new preprint:
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@jx_hoffman @bmart87 Thanks Jackson! I'll start by reading your work carefully. Once I have my head around it, it would be great to talk.
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Our work led by the great @missing_a_rib! See his follow up poster/ short talk on how using personalized genotypes improves SNP effect prediction. #MLCB2024
Concurrently-developed deep learning models to capture transcription initiation syntax: @anshulkundaje lab's ProCapNet @charlesdanko lab's CLIPNET #MLCB2024
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RT @compbiologist: Concurrently-developed deep learning models to capture transcription initiation syntax: @anshulkundaje lab's ProCapNet…
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So in sum, these are interesting and valuable experiments. I look forward to talking over our separate interpretations with Chunaram and members of his lab. Hope to see them at a conference soon!
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