Bioenergetic Space
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Building on Ray Peat's ideas. Energy creates life, and life creates energy. Ray Quotes:
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The cancer pandemic is here - and boomers are the super-spreaders
Mainstream health recommendations are so horrible that for the first time, children have MORE cancer than their parents!
The worst increase is in thyroid cancer. I wonder why...
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POV: You are about to receive advice that will shorten your lifespan by 15 years
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Belly fat is very unattractive in men.
An evolutionary signal of defeat, since it is driven by high cortisol.
But stearic acid specifically targets and shreds abdominal fat.
It reduced belly fat by 70%!
Chocolate, beef fat, and dairy are sources of stearic acid.
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IQ is one of the biggest predictors of life success. Most "experts" will tell you it's fixed at birth.
"Genes," they say... LOL!
Vitamin E supercharges cognitive performance by 45%!
Mechanism:
-Less NO
-More mitochondria
-More energy production
-Less lipid peroxidation
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Advice on hair loss:
The final common pathway of hair loss is microcapillary calcification leading to hair follicle hypoxia.
It can be reduced by:
-Vitamin D: 5000 IU
-Vitamin K2-mk7: 200mcg
-Magnesium: 500mg
-Taurine: 2 - 3 g
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A bottle of 50 grams of thiamine goes for almost $20, and you can buy a KILO of German-quality thiamine for about $80. That's 20x more B1 for 4x the price.
They are just laughing at us at this point. This is why I only order wholesale and make my own supplements.
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Coconut oil: Unique benefits
Coconut oil is:
- Antihistamine
- Anti Cortisol
- Pro Immunity
- Anti Cancer
It also has other properties that make it unique:
Coconut oil increases the metabolic rate
Yucatan people with a coconut oil-rich diet have a 25% higher metabolic rate
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Fear and anxiety are the mind killers. The little deaths that bring total obliteration.
Possibilities are not perceived and open doors become closed. The organism is limited. It retreats.
But niacinamide, 1500mg per day, destroys fear and anxiety by boosting GABA signaling.
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New Study: Coffee better than chemotherapy
Just 4 cups per day are enough!
Same results in preventing aggressive cancer (30% less recurrence) as when using toxic chemotherapy (5-Fluorouracil), but with no side effects
Caffeine is a vitamin-like nutrient. Ray Peat vindicated
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Caffeine (and uric acid) makes you smarter and richer
Men with higher uric acid have both higher intelligence scores and more income.
Uric acid acts as a safe brain stimulant and antioxidant, similar to caffeine.
"A deficiency of uric acid is a serious problem" - Ray Peat
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I'M SO BACK!
The last few months have been very hectic and busy, but I'm getting back to uuhh... p-peatposting.
Every time I reread his newsletters he gets even more genius. Lots to share!
Look forward to pic below in the coming months.
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Ray Peat NEVER defended overeating to "boost metabolism."
In one newsletter he talks about 2100 kcal/day as a normal metabolic rate.
When asked for weight loss tips he answered to avoid high calorie foods like full-fat milk.
Calories are real and being fat is not peaty.
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The basic anti-aging diet, according to Ray Peat:
-High Protein
-Low PUFA
-Low iron
-Low starch
Main foods: milk, cheese, eggs, shellfish, fruits and coconut oil.
Safe supplements: Vitamin E, Magnesium, and salt.
From his newsletter: "Diabetes, scleroderma, oils and hormones"
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DHT is probably the male equivalent to Progesterone, since both share a unique trait: Stimulating their own synthesis.
Protective hormones with positive feedback loops allow us to escape stressful situations constructively, becoming more than we initially were.
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Soviet pharmacology developed without Western influence and produced drugs like Cytofalvin, directly aimed at increasing ATP. The ingredients are:
- Inosine
- Riboflavin (B2)
- Niacinamide (B3)
- Succinic acid
It is even used intravenously.
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Losing fat in a healthy/peaty way (long-read)
Being fat is not good for you. Body fat will reduce your capacity to burn glucose, increase estrogen, and keep blood fatty acids always elevated. But most weight loss advice is not healthy or sustainable. Here is how I approach fat
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The real causes of hair loss and how to block them:
-Prolactin: Lower estrogen with protein and B Vitamins
-Aldosterone: High salt intake
-Cortisol: Low PUFA, high SFA
-Hypothyroidism: High-carb/high-sugar
Hair loss is a systemic body-wide issue that should be taken seriously
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High cortisol destroys brain white matter.
But this is easily reversed with Pregnenolone, Progesterone, DHEA, or Testosterone. Any substance that increases the synthesis of these protective hormones will help.
Study the peat hormone chart well! Retardation is optional for
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Spice melange is so effective at prolonging life and enhancing mental faculties because it saturates the brain and tissues with a non-toxic form of copper.
Copper depletion is one of the main causes of aging.
Ray Peat was searching for a nontoxic way to get lots of copper.
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Oxytocin is usually associated with orgasm and pair bonding, but hormones have complicated and nuanced meanings:
Abused women have dramatically elevated levels of Oxytocin.
Also, Oxytocin increases violent responses in high-aggressiveness men.
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High doses of Vitamin A reduce levels of body fat, and if you are not obese they outright reduce the amount of adipocytes, which is very protective against future obesity.
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Optimizing insulin sensitivity builds as much muscle as anabolic steroids!
Using chromium gave 42% more muscle gain and 22% body fat loss.
These numbers are only seen with anabolic steroids
Being insulin-sensitive is literally a superpower
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PUFAs make you submissive
A strong metabolism leads to an organism biologically driven to impose boundaries
Omega-3 supplements make people up to 30% less "aggressive," which is newspeak for submissive
Depleting PUFA with coconut oil will make you more confident and assertive
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Estrogen, the powerful stress hormone, meets its match: B Vitamins and Protein!
Abundant protein and B Vitamins allow the liver to detoxify estrogen as fast as it is produced.
Simple but effective: Milk, liver, eggs, cheese, gelatin.
Take them away - estrogen skyrockets.
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As we get older we no longer adapt or improve. We remain stuck in our ways even if they hurt us. Challenges overwhelm us.
Our fluid genes become fixed.
But Vitamin D extends youth and keeps us adaptable and flexible by stopping the DNA methylation that comes with aging.
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Whenever I think that I may be pushing things too far I remember that Ray experimented with Ephedra for sleep and took thyroid while burning 7000+ kcals per day and I conclude that I'm not pushing things enough.
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I am happy to announce that my caffeine consumption has reached one gram per day.
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The only Soviet physiology textbook translated into English of the era when Peat visited the USSR.
Text-Book of Physiology, (Bikov, et al)
If you want a Peaty approach to begin your studies of the human body, this is it.
Available for free on Archive.
Happy learning!
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Was sipping coffee when I saw a young girl, 5 or 6, happily dancing, prancing, and jumping around from corner to corner.
That's when it hit me: This is what we are after. Vitality, joy, smile energy.
All the hormones and substances we take are not in pursuit of an artificial
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Retrocausality: The future affects the past
Studying after a test improves the performance of students.
The future ripples or bleeds into the present. How so? Ray said that time flow may be a continuous source of energy and negentropy.
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Ray Peat was well known for talking about studies that were impossible to find. Well, almost impossible...
Remember the whole "small doses of caffeine have a sedative effect"?
I finally found the study. From the Soviet book, How reliable is the brain
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According to Ray, maleness is a specialization on top of femaleness, which is the basic developmental path for a human.
Testosterone has both progesterone's stability and estrogen's stress hormone character.
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Your creativity is a function of your metabolic rate.
Sugar, B1, B3, T3, pregnenolone, and methylene blue is what I take when I need to see things in a new way (aka every day).
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Meldonium is one of my favorite substances. It reduces fatty acid oxidation so potently that you immediately feel lighter on your feet and more energetic.
It works by blocking Carnitine synthesis and reducing FFA transport to the mitochondria.
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Hopeless people become obese, but dopamine stops and reverses this.
A supportive environment and hope for the future are the basic ways to avoid this, but if they are not available we have alternatives!
-Caffeine
-Thyroid
-Sugar
-Magnesium
-Vitamin B6
-Tyrosine/Phenylalanine
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In the absence of enough protective Progesterone, every ovulatory estrogen spike becomes a neurotoxic event that eventually results in the death of neurons that restrain estrogen release. This is menopause.
It's not the eggs, it's the brain.
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Just increasing protein intake leads to increased muscle mass without exercise.
Anabolic hormones like pregnenolone further increase muscle by blocking cortisol, again without exercise.
Healthy men are naturally muscular and toned even without weightlifting.
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Brains keep growing.
Definitive proof that intelligence is not just "genetic" and CAN be improved!
A generational 6% increase in brain volume in 30 years with 14% expansion of the neocortex surface, the part that makes us intelligent
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Trauma has lifetime repercussions, but blocking serotonin extinguishes it, reframing the harmful memories.
A bad childhood leads to early puberty and aging.
But the organism is flexible.
Change is always possible under the appropriate environment and biological influences.
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Hungry men find heavier women more attractive. This effect disappears when men are satiated.
"Nothing in biology makes sense except in the light of evolution"
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The demented "Ray Peat" forum owner prohibits posting any pro-Vitamin A research.
Claims that if one wishes to post such research there are other forums.
This begs the question... Why is that site still called the "Ray Peat" forum if you can't post peaty research?
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Testosterone alone is enough to return obese men to a normal weight.
Continuous weight loss for eight years.
No diet, no exercise.
The dose used comes out to 8.5mg per day, the normal production of a healthy young man.
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Intense metabolism generates a bio-electric field that extends outwards from the body.
Ray talks about his field being so strong that it distorted cell potential measurements.
At least two species can sense this field: sharks (for hunting) and cute girls (purpose unknown)
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T3 cures MS, ALS, Cancer, low IQ: Yes, of course
T3 cures obesity: NOOOO. Cheater! Hack! Roider!
Lol lmao even
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Most people get fatter after a diet.
Now we know why: cortisol. A big calorie deficit raises cortisol so much that any extra calorie gets immediately stored as fat
Solution => lower cortisol while dieting:
-High carb
-Pregnenolone
-Moderate deficit (no more than 500 kcal)
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Novelty can cure depression.
When you enrich the environment of depressed rats, they get better.
Novelty activates the brain and induces it to reorganize and reorient towards reality. This reorientation affects the whole perception of the world.
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Tryptophan rots your brain!
Administering Tryptophan to rats induces oxidative stress in the most vulnerable part of the brain: the cortex.
But Taurine, Vitamin C and Vitamin E protect.
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A project I'm working on (still in development): It's a repository of Ray Peat Quotes and highlights that I have collected over the years, ordered by topics.
Each quote can be upvoted, and I hope that over time, the most helpful will come to the front
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Aging and degeneration begin in your early 20s.
It is never too soon to take basic protective steps! Start now. They will compound in your favor:
-Eliminate PUFA
-Adequate calcium and Vitamin D
-Eliminate endotoxin-producing foods
-Find a supportive and stimulating environment
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If you drink a lot of milk (like I do - 3 Liters) and also take >5000 IU of Vitamin D, Vitamin K starts to become essential in high-ish doses.
You will absorb a lot of calcium, and without ample Vitamin K to handle it, it could end up deposited in soft tissues.
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If you have anxiety take some Vitamin B6 to increase your GABA.
As a bonus your Dopamine will also increase and your Prolactin decrease.
Vitamin B6 = High GABA (calmness) + High Dopamine (motivation) = Winners Combo
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Nitric Oxide makes Oxygen useless, cells suffocate
Stressed cells can't breathe even if there is plenty of oxygen! Nitric Oxide blocks the enzyme that uses oxygen to create energy
If NO finds this enzyme it's stuck
But two things can kick out NO: methylene blue and red light
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Fasting can make you skinny-fat. Combine with cardio far maximally catastrophic results:
1. Tanks your metabolism,
2. Increases cortisol,
3. Destroys protein tissue.
Many people have permanently worsened glucose tolerance after a fast. Avoid!
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Ray thought the loss of copper and its replacement by iron was one key to aging.
But he also warned that there isn't enough knowledge about how to safely supplement large amounts of copper, and recommended opting for high-copper low-iron foods instead.
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Creativity is the only form of adaptation that does not damage the organism over the long term.
The brain is the organ of adaptation.
RP: "Adaptation at any other level than creative imagination is a bodily stress."
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If you have motivation and concentration problems, Vitamin B6 can help.
Some scientists think that ADHD is centrally connected to Vitamin B6 deficiency.
There are anecdotal reports of children with ADHD drastically improving after taking B6.
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DHT both increases Progesterone and Lowers cortisol - at the same time.
Change literally one key thing and the positive feedback cycles will align many more in your favor.
Let your body work for you.
Thyroid, Calcium, etc, are also part of this special group.
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Energy allows us to adapt in constructive ways by changing our structure.
Insight reduces the amount of energy needed to mount a successful adaptation to a challenging environment.
Without energy and insight, we depend on destructive stress systems that lower our time horizon
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CO2 literally makes mitochondria spring into existence. It is also produced mainly in the mitochondria
More mitochondria => More CO2 => Even more mitochondria
Less mitochondria => Less CO2 => Even less mitochondria
Positive feedback determines if biology goes in your favor.
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DHT and Testosterone both protect from excess cortisol damage while also reducing the reactivity of the hippocampus to toxic levels of cortisol.
Androgens are excellent cortisol blockers, and DHT is probably the most potent one, in the same order as Progesterone.
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Ray Peat seems to be the first one to have told the obvious truth that the main "ketone" body of the "ketogenic diet," BHB (beta-hydroxybutyrate), is not a ketone but an alcohol.
And this makes all the difference.
Ketone = oxidized = good
Alcohol = reduced = dangerous
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Intermittent fasting explodes your heart.
91% higher chance of a heart attack!
Comfy snacks every few hours for me, thanks.
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Reminder that Ray saw obesity as a dangerous illness.
"You have to eat more to increase your metabolism" may have some merit, but many people become obese in the process.
RP diet is designed to increase metabolism. If you are gaining unwanted weight something has gone wrong!
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Marathon runners are so diseased that after a race, their brain tissue literally shrinks. Myelin disappears.
But don't worry, after a few weeks, it "partially recovers."
Take a look at the picture. Post-exercise, it looks like severe brain damage.
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Insulin resistance is just another name for damaged glucose burning, no wonder it is found in most diseases.
You have three ways to get rid of it:
-Improve thyroid function until TSH < 1
-Inhibit lipolysis and FFA oxidation
-Lose excess body fat
Also, low carb does NOT work!
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I don't do dopamine fasts - I do dopamine binges.
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Exhaustive exercise => Obesity & room temp IQ
Just one bout of exhausting (aka lactic acid producing) exercise is enough to:
-Skyrocket cortisol
-Lower metabolic rate, leading to weight gain
-Lower body temperature, which is directly correlated with lower IQ
Avoid!
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Simple immune boosting "protocol" that works (in my experience)
-Zinc: 20mg
-Copper: 3mg
-Selenium: 200mcg
-Vitamin D: 5000IU
-Niacinamide: 1000 - 1500mg
Before finding Peat I had bacterial infections and this combination worked well. If I stopped the infections returned
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Low social status is inflammatory and activates the same protein (TLR4) as endotoxin does.
Also, low social status decreases antiviral responses.
Low status is a serious thing and should be addressed with appropriate biological interventions if it cannot be changed.
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Peating ENDSIEG:
-95% pregnancy success for 40+ yo women
-Male height increases to 6'+ after 25 yo
Once there, we will have solved most other biological problems along the way.
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Forever chasing the feeling I got when I took T3 for the first time.
Instantaneous cognitive and perceptual reconfiguration, but without LSD demons.
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Ray was probably the first to draw a hard line between Vitamin D and calcitriol (a Vitamin D metabolite).
Vitamin D and 25-OH-calciferol are good, but calcitriol is a dangerous stress metabolite.
So many pro-vitamin D people get this wrong and mess up their arguments.
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Low social status is a powerful stressor that mimics learned helplessness.
But one good experience is all that is needed to escape learned helplessness.
One time, one choice, one word, can be the difference between drowning in a few minutes or resisting for hours.
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One anonymous feels report > 10 peer-reviewed double-blind studies
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During pregnancy, a woman's body is taxed to its physiological limit.
A diet that gets the best outcomes for mother and child would generally benefit both men and women during stressful times.
According to Ray, this is:
-High Sugar
-High Milk
-High Protein
-High Salt
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I bring you the most powerful molecule you have never heard of:
2,6-dimethoxybenzoquinone
Hypothesized by Szent-Gyorgyi to have unique pro-metabolic and immune-enhancing properties, and to be the main factor in his long years of good health.
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If you struggle with lowering serotonin and don't tolerate Cyproheptadine, taking Zinc can be an easy alternative.
Zinc increases Serotonin uptake in a similar way to Tianeptine, without its negative side effects.
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The structure of LSD and related ergot alkaloids encodes basically every major neurotransmitter.
"How many functions would you like your compound to have?"
"YES"
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The first thing I noticed after taking progesterone was how much my sense of humor increased
I was visiting my parents and 10 minutes after the first Progest-E dose my sister was BEGGING me to stop. She was hurting from laughing too much.
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An unrecognized cause of cognitive impairment is subacute unnoticed migraine/headache.
But Vitamin D has been shown to tank migraine attacks. Combine with Caffeine and Aspirin (classical headache combo) for a migraine-proof brain.
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Years ago I compiled a list of non-official remedies for serious diseases that people were reporting success with, or that had published research behind it.
I did not distinguish between peaty and non-peaty things.
Once lost - now reappeared...
*Informational purposes ONLY
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I have trialed in friends a custom topical product for hair loss that seems to work really well. Ingredients are:
-Zinc Sulphate
-Pyridoxal 5 Phosphate
-Caffeine
-Adenosine
The results seem to be a complete halt to hair loss. New noticeable growth in 50% of cases.
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4- chloro-phenylalanine (PCPA): Tanks serotonin to ZERO
PCPA irreversibly inhibits Tryptophan Hydroxylase I and II (TPH), the enzymes that synthesize serotonin (5-HT).
Doses of one gram in humans make 5-HT undetectable by luminescence. But lower doses help lower excess 5-HT.
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MODIFIED AMINO ACID CHEAT SHEET:
Tryptophan: Cancer
Methionine: Cancer
Arginine: Cancer, but with more blood flow
Cysteine: "I don't need my thyroid gland"
AMINO ACID CHEAT SHEET:
Arginine: nitric oxide
Cysteine: glutathione
Citrulline: blood flow
Glycine: collagen/sleep
Glutamine: gut health
Leucine: muscle growth
Methionine: methylation
Taurine: eye health
Tryptophan: sleep
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Pizotifen is a serotonin antagonist like Cyproheptadine but does not block histamine or dopamine, so you will not get tired or feel low-energy when taking it.
The structures are almost the same. Left Cypro, right Pizo.
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Fructose > Sugar > Glucose
For avoiding sugar crashes and limiting insulin release.
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Because Ray defended carbs as main fuel, some people think that he also defended insulin, and that insulin must be good. Not true.
Excess of insulin is very dangerous! Read the screencaps!
Unless you are bodybuilder or athlete your needs for it are vanishingly low!
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Body fat:
1. Increases free fatty acids => Reduces glucose metabolism, less CO2
2. Highest concentration of aromatase => Increases estrogen, less androgens
Least peaty tissue by far. Unless you are underweight you will benefit from cutting excess body fat
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Ray Peat: "These newer molecular approaches to the study of biology are vindicating some of the practical observations of plant and animal breeders, and terms such as telegony, heterosis, and xenia might come into common use again, along with genomic imprinting"
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The evolutionary potential of humans is frustrated by our need to respond and adapt to stress.
If we learn to overcome or eliminate it, we can increase our most human features like intense metabolism, playfulness, and flexibility.
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Brain energy production directly predicts fluid intelligence.
Anything that increases the energetic efficiency of neurons will help you solve problems and adapt to novel circumstances.
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If you are losing fat, caffeine and activated charcoal are absolutely essential
Fat loss liberated stored chemicals. The liver needs to process (glucuronidate, sulfate, etc) these toxins and excrete them
Caffeine induces liver detox enzymes.
AC binds the toxins in the GI tract
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Low-carb scam: Wanna lose weight? Become a "fat burner."
But... Mice genetically forced to burn fat like crazy lose no extra weight. LOL
The only thing high levels of fat burning are associated with is disease. Avoid! Burn sugar, eat tasty things => be lean and energetic.
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As strange as it sounds, the human body treats opiates like endotoxin.
Corollary I: Naltrexone blocks many of endotoxin's bad effects
Corollary II: The endogenous opiates are just as bad as exogenous ones, and contribute to many diseases
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The "love hormone" seems to be behaving like a stress hormone. This makes sense since Oxytocin is related to Vasopressin, a classical stress hormone.
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Biohackers think that they invented L-theanine + Caffeine in the 21st century.
But Pavlov was combining Bromide (a sedative) with Caffeine 100 years earlier and getting the same results.
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Ray experimented with taking Ephedra (a stimulant) at night to keep blood sugar up!
This is the kind of spirit we need when experimenting. A crazy idea may just be what works best.
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A doctor uses low T3 as a marker for "compliance" to a low-carb diet.
Carb-eaters trip his "BS detector" because their serum thyroid is too high.
@KetoCarnivore
Yep. I use FT3 in bloodwork as my BS detector to see whether people are consistent with a low carb diet.
Generally 3.0 is the cut off point. Above is a higher carb diet and lower than 3.0 is a lower carb diet.
Doesn’t work well if someone has hypo or hyperthyroid.
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Mice can have a metabolic rate that is as much as 30% different.
This explains why some people lose weight without effort. If your metabolic rate is 30% higher, a mild caloric deficit is all that is needed.
This is why fixing metabolism comes before a caloric deficit
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