Anne Lopes
@anne__lopes
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Joined January 2018
Our work on the role of the noncoding genome in de novo gene birth and protein evolution is online now! @genomeresearch @namyolivier @I2BCParisSaclay
@IMPMC_Lab @DSIMB_Lab
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RT @lizzyzhao: Nicolas Svetec, David Begun, and I wrote a review article about de novo genes. If you are interested in this topic please ta…
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RT @VSLioy: @anne__lopes & coll explored the ribosome profiling landscape of yeast and showed that noncoding regions are associated with a…
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RT @VSLioy: Bioinformaticians of the #GenomeBiologyI2BC , Lille University & Montpellier University find new ways to analyze cancer RNA in…
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Finally, we show that the translation outcome of a noncoding ORF is primarily determined by the initiating codon and the codon distribution in its two alternative frames, rather than features indicative of functionality.
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@I2BC @BioCgpapado @namyolivier @GenomeBiology Our findings suggest that noncanonical translation signals may harbor valuable information and underscore the significance of considering them in proteogenomic studies.
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we show that noncoding regions encompass a wide diversity of RiboSeq signals and populate the entire landscape. Our results show that pervasive translation can, nevertheless, be associated with high specificity, with 1055 noncoding ORFs exhibiting canonical RiboSeq signals.
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we show that coding regions occupy specific areas of the Ribo-Seq landscape, that young CDSs can be associated with noncanonical RiboSeq signals, and that altORFs could be detected with proteomics despite being associated with noncanonical RiboSeq signals.
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RT @carvunis: Is complexification of protein complexes always a good thing? Our Spotlight on an excellent paper from Christian Landry's lab…
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RT @BioCgpapado: Very excited about our recent work with @anne__lopes exploring the ribosome profiling landscape of yeast and detecting p…
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DENSE is out! Mine your genome and highlight its de novo genes :D
De Novo Emerged Gene Search in Eukaryotes with DENSE | @scoopit @anne__lopes @GenomeBiolEvol
#denovogenes
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RT @jessica_compbio: Choose France - CNRS AI Rising Talents This program offers exceptionally talented early-career AI researchers with the…
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RT @jruizorera: Happy to share our new manuscript published in @NatureCVR! 1) Curious about how genes, small open reading frames (sORFs) an…
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DENSE is out and ready to mine your favorite genome for its de novo genes! Try it out!
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RT @vakirlis: My latest collaboration with the one and only Anne-Ruxandra @carvunis is out in @GenomeBiolEvol ! Can we determine if/when a…
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RT @carvunis: Ancestral Sequence Reconstruction is a powerful approach for inferring evolutionary trajectories. How powerful is it for youn…
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RT @jo_schacherer: Population-wide transcriptomes and proteomes reveal distinct genetic control of gene expression. Great work by Elie Teys…
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RT @jessica_compbio: 📢🚨 job alert! A permanent bioinformatics engineer position is open on the Integrative Bioinformatics Platform (BIOI2)…
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