Andrew Piggott
@andrewpiggott
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Bioorganic / Natural Products Chemist at Macquarie University
Sydney, New South Wales
Joined March 2011
Excited to share that my paper has been published in ACSChemBio! A great collaboration with @ZhuoAlexShang1 and @YitHengChooi. Thanks to my spvs @petersolomon99 @McdonaldMeganc and other collaborators @BracegirdleJoe @andrewpiggott @DrMogg
pubs.acs.org
Rhynchosporium commune, the causal agent of barley scald disease, poses a major threat to global barley production. Despite its significant impact, the molecular mechanisms underlying R. commune’s...
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Self-Resistance Gene-Guided Discovery of the Molecular Basis for Biosynthesis of the Fatty Acid Synthase Inhibitor Cerulenin (Yit-Heng Chooi and co-workers) @YitHengChooi @ZhuoAlexShang1 @amrarishi @SMS_UWA @andrewpiggott @mqnatsci
onlinelibrary.wiley.com
Cerulenin is the first reported fatty acid synthase inhibitor, yet its biosynthesis has remained elusive for six decades. The biosynthetic gene cluster of cerulenin has now been uncovered from the...
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Our work on the biosynthesis of Aquastatin anti-MRSA #antibiotics now online @ChemicalScience ! Congrats to Nicolau Sbaraini for his #MyFirstChemSci 🥳 Another great collab w/ https://t.co/GUXhRwxG48
@andrewpiggott @mqnatsci @SMS_UWA Checkout here: https://t.co/TI0UMCPdob
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By fantastic collaboration with @YitHengChooi @andrewpiggott @amrarishi @DrMogg @clmgilchrist Dr Ernest Lacey at @SMS_UWA @mqnatsci and MST, we uncovered the decades-old biosynthetic mystery of fatty acid synthase inhibitor cerulenin using a self-resistance gene-guided approach.
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Excited to share our recent work, "Self-Resistance Gene-Guided Discovery of the Molecular Basis for Biosynthesis of the Fatty Acid Synthase Inhibitor Cerulenin", is now published in @angew_chem!
onlinelibrary.wiley.com
Cerulenin is the first reported fatty acid synthase inhibitor, yet its biosynthesis has remained elusive for six decades. The biosynthetic gene cluster of cerulenin has now been uncovered from the...
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Thrilled to announce our manuscript about the biosynthesis of the sterol O-acyltransferase inhibitor helvamide has been published online @JOC_OL . Enjoyful collaboration with @YitHengChooi @SMS_UWA @andrewpiggott and Microbial Screening Technologies.
pubs.acs.org
We have identified the biosynthetic gene cluster (hvm) for the sterol O-acyltransferase inhibitor helvamide (1) from the genome of Aspergillus rugulosus MST-FP2007. Heterologous expression of hvm in...
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So excited to share the wonderful news that our luteodienoside A paper was accepted to @ChemicalScience
https://t.co/A0d8wuG8LX. I would like to thank my supervisor @YitHengChooi @SMS_UWA and our fantastic collaborators @AndrewPiggott @HangLi13 @ZhuoAlexShang1 and Ernest Lacey
pubs.rsc.org
Luteodienoside A is a novel glycosylated polyketide produced by the Australian fungus Aspergillus luteorubrus MST-FP2246, consisting of an unusual 1-O-β-d-glucopyranosyl-myo-inositol (glucinol) ester...
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Talcarpones are unusual bisnaphthazarin derivatives produced by a novel Australian fungus, Talaromyces johnpittii. A wonderful collaboration with John Kalaitzis, @msb_chem, @yptan80, Roger Shivas and "team MST". @mqnatsci @ILSE_UniSQ @NaturePortfolio
https://t.co/zWEqTqWcpt
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Congratulations to @MichaelCowled1 for his elegant paper in JNP showing how dueling fungi can produce some interesting new chemistry! Thanks to John Kalaitzis, Nico Sbaraini and the wonderful team at MST. @mqnatsci @SMS_UWA @ACSPublications @pharmacognosy
https://t.co/mYFR1oamdP
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Turonicin A is an antifungal polyketide produced by a Streptomyces sp. from the banks of the Turon River, NSW. Thanks to @msb_chem, John Kalaitzis, @YitHengChooi, Maira Rosin + the team at MST. @mqnatsci @SMS_UWA @LeibnizHKI @ACSPublications @pharmacognosy
https://t.co/7YzfYOz0AM
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Don't miss out on the exciting AusNZ #NaturalProducts Chemistry & Biology Symposium in 🇦🇺#Perth! Exciting speakers await. ECRs and students seize this opportunity to showcase your work! And #SBA2023 in the same week too. Please #RT
https://t.co/kVMSrcyt4H
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Our paper describing the discovery of the resorculins is now available! It is the latest work from the collaboration between Microbial Screening Technologies and the Rutledge, @YitHengChooi and @andrewpiggott labs! Thread follows... 1/5 https://t.co/qYRrFuM17a
pubs.rsc.org
Fourteen-membered macrolides are a class of compounds with significant clinical value as antibacterial agents. As part of our ongoing investigation into the metabolites of Streptomyces sp. MST-91080,...
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It was a pleasure collaborating with John Kalaitzis @msb_chem and the amazing team at Microbial Screening Technologies on these interesting natural sunscreens isolated from the charmingly named "Dog Vomit Fungus" @mqnatsci @ACSPublications @pharmacognosy
pubs.acs.org
The myxomycete Fuligo septica, colloquially referred to as “dog vomit fungus”, forms vibrant yellow fruiting bodies (aethalia) on wood chips during warm and humid conditions in spring. In 2018, ideal...
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Excited to share my new paper on a suite of berkeleylactones in Journal of Natural Products @ACSPublishing and @pharmacognosy. Great collaboration between @andrewpiggott, @YitHengChooi, @HangLi13, @clmgilchrist and Ernest Lacey @mqnatsci @SMS_UWA
https://t.co/QhGeeskEJO
pubs.acs.org
Penicillium turbatum has previously been reported to produce A26771B, a 16-membered macrocyclic polyketide with activity against Gram-positive bacteria, mycoplasma, and fungi, as well as the struct...
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Excited to share a preprint of our work with Microbial Screening Technologies, @andrewpiggott @PaulsenLab and team We profiled the skin microbiota of over 1000 cattle in Australia as the first step to developing sustainable therapies for pest infestation https://t.co/5QHKvnve3Z
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In our cross-journal collection on Antibiotic and Antiviral compounds, @andrewpiggott & co at @MQMolSci report the semisynthesis and in vitro biological evaluation of a focused library of unguinol derivatives as next-generation antibiotics ⬇ https://t.co/AmGwxrpkFf
pubs.rsc.org
In this study, we report the semisynthesis and in vitro biological evaluation of thirty-four derivatives of the fungal depsidone antibiotic, unguinol. Initially, the semisynthetic modifications were...
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Excited to share our comprehensive review about #fungalpiperazines just #onlined @NatProdReports. Another enjoyful collaboration with @YitHengChooi @SMS_UWA @uwanews and @andrewpiggott @MQMolSci #naturalproducts
pubs.rsc.org
Covering: up to the end of July, 2022 Fungi are prolific producers of piperazine alkaloids, which have been shown to exhibit an array of remarkable biological activities. Since the first fungal...
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Huge congratulations to @YitHengChooi @SMS_UWA on your promotion to Associate Professor! Incredibly well deserved! It has been an absolute blast collaborating with you and your amazing team over the past few years and I can't wait to see what you will achieve in the future! 🎉🍾
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Suertides are antibacterial cyclic hexapeptides produced by an Amycolatopsis sp. found in riverbank soil collected near El Pont de Suert, Spain. With Heather Lacey, Peter Rutledge, Mark Fisher and "Team MST"! @MQNatSci @SydneyChemistry @NaturePortfolio
https://t.co/piEDvo50Hb
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