A. James Link
@ajlinklab
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Research group at Princeton in Chemical and Biological Engineering
Princeton, NJ
Joined September 2016
RT @yitang_ucla: In a year with so little to cheer about so far, I am happy to share our manuscript on a copper-dependent halogenase. Unbe…
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There are 56 predicted cysimiditides scattered around actinobacterial genomes. We originally found some cysimiditides as part of our study on imiditides, linear peptides harboring an aspartimide:
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RT @biorxiv_biochem: Cysimiditides: RiPPs with a Zn-tetracysteine motif and aspartimidylation #biorxiv_biochem
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RT @piel_lab: Congrats to @HubrichFlorian & @sanathrajkk0 for this exciting story finally being published. Thanks for the fruitful collabor…
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RT @NinaHartrampf: Thank you for highlighting our work on the chemoenzymatic synthesis of modified lasso peptides on the covers of @J_A_C_S…
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RT @ZhongyueY: AlphaFold can't tell you the structure of lasso peptide, a major branch of RiPPs and promising antibiotics. Xingyu wasn't ha…
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RT @DrewCarson712: Excited to be at @BostonBacteria at Boston Univ! Looking forward to some great science #BBM2024 🧫 I’m presenting poster…
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RT @NinaHartrampf: Our chemoenzymatic synthesis of the lasso peptide Microcin J25 is out now in @J_A_C_S! We used flow-SPPS to synthesize s…
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RT @yitang_ucla: Early Announcement! Together with Brad @BradMoore_SIO, Jaclyn @JMWinterlab, and Alessandra @Eustaq…
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RT @isciverse: Cyclic Peptides from Graspetide Biosynthesis and Native Chemical Ligation @J_A_C_S #Chemistry #Chemed #Science #TechnologyN…
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Then, we use those thioesters to do native chemical ligation and make some interesting cyclic and branched peptide structures. Congrats to Brian and former Link lab senior thesis student Arthur Acuña ‘23!
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@DrewCarson712 already posted an excellent thread about the work, so please take a look: @EPrinceton supported by @NIGMS
Our new paper is just out now in ACS Chemical Biology! Here we uncover the transport pathway that the antimicrobial lasso peptide cloacaenodin uses to be able to kill susceptible bacteria. This helps explain the narrow-spectrum activity we observe.
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RT @ASBMB: #DiscoverBMB: Join us for the #biochemistry and #biotechnology of natural product #genome mining session at 9 a.m. in 214BC! L…
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