Zhixing Chen
@ZhixingChen2
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Chemistry, Molecular Engineering, BioImaging, Biotechnology. Columbia/Stanford alumni. Asso. Prof. at College of Future Technology, Peking University
Beijing
Joined August 2020
Video abstract of PK Mito Orange prepared by our collaborator Dr. Till Stephan
PKMO: a new dye by @ZhixingChen2 that allows multi-color live-cell STED of #mitochondria. We´re so excited about this wonderful collaboration that we prepared a video to highlight some of the data recorded by @TianyanL and @stephan_till . 👇
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RT @kenneylj: My heart is broken as I announce the passing of my beloved husband, science partner and friend, Michael Sheetz. A remarkable…
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RT @stephan_till: Happy New Year, everyone🍀 Excited to see one of my live-cell STED super-resolution microscopy images featured in this ye…
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@sturm_gav Thank you! can you follow me or email me so I can message you for further technical discussions? Thanks and looking forward!
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How proximal is proximity labeling❓ Using DNA nanorulers we found that TurboID/BioID are largely contact labeling, while APEX2 also bears a major contact labeling pathway in parallel with diffusive labeling. Special thanks to Alice Ting for discussions!
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Great collaborations between junior PIs😀PK mito dyes excel in applications beyond imaging and beyond traditional model animals!
I am thrilled to share our paper Mitochondrial dynamics govern whole-body regeneration through stem cell pluripotency and mitonuclear balance| Nature Communications great collaboration @Orangeroad2017 @ZhixingChen2
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RT @chemhualu: the department of polymer at Peking University is looking for 2 PIs at both junior and mid-career levels, all backgrounds ar…
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I'm flattered everytime I see a multi-color movie with our gentle dyes together with mStayGold!
Time-lapse recording of floorplate cytonemes (green) interacting with axons (magenta). 1 image taken every second for 10 min (played at 30 fps). Cytonemes love interacting with axons! 💚#FluorescenceFriday
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Our Gentle Rhodamines is finally published @ACSCentSci. See the healthy cytoskeleton free from photodamage even after 800 frames! 🦾💪 Great collaboration with Julian Kompa, the Johnsson group, and Spirochrome! @JulianKompa @spirochrome @TianyanL
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RT @Orangeroad2017: A nice talk from Stefan in PKU, with a lot of mitochondria, superresolution, and some twists to cryoEM in the end . The…
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RT @spirochrome: 🎉🍾10 YEARS - NEW WEBSITE! 🎂 Join us in celebrating Spirochrome's 10th anniversary and visit our new website! https://t.co/…
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Nice work!
Since long time we tried to achieve “permanent” labelling of plasma membranes. Now it become possible with MemGraft probes, which exploit a new principle of lipid-directed covalent fluorescent labeling of membrane proteins. The MemGraft probes are compatible with fixation, permeabilization, trypsinization, presence of serum in the medium and enable long-term cell imaging, co-culture of cells and their imaging in multiple colors, cell barcoding and cell manipulation. Congrats and thanks to co-authors: Nathan Aknine @n_aknine & Remi Pelletier. @unistra @CNRS @CNRS_Alsace @LBP_Illkirch Just out in biorXiv:
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RT @rita_strack: Very sad news. He was a pivotal contributor to the probes community and beyond.
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@Mayeul_Collot @LydiaDanglot Yes the MemBright dyes are already very gentle for time-lapse imaging. PK Mem gives some extra boost along this line.
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Glad to launch another collaboration with SpiroChrome! @spirochrome
🚨MORE NEW PRODUCTS🚨 The new and amazing "Gentle" Plasma Membrane (PM) PKmem™ probes from @ZhixingChen2 lab will be available at Spirochrome by the end of May. PKmem probes advantages: ✅Fast staining ✅Reduced phototoxicity ✅Robust and specific PM staining ✅SIM & #STED compatible ✅Allow extended long term live cell imaging ✅Work on live & fixed cells ✅ 3 colors/channels available for flexible multicolor imaging Make sure to give our account a follow so that you don't miss out more🤯new products to be soon launched at Spirochrome! 🤫😉
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