Super excited to share our new preprint from the @YinShenLab. We developed PRIME, a high throughput prime editing screen method. PRIME allows us to characterize the human genome at the base pair resolution and at scale. 1/8

@bsadamson Congratulations!

@JianXuLab Congratulations 🎉🎉

@dbgoodman Congratulations

RT @Xieeee4: Chromatin interactions profiles are useful, but how can we deconvolute cell-type info from the complex tissues? 🎯 Led by @LeiC…

@hsiung_chris @YinShenLab Thank you, Chris!

@YaruiDiao Thank you for developing the CREST-seq.

In summary, our findings unravel a regulatory compensation mechanism that ensures stable and precise transcriptional output for SIN3A and potentially other dosage-sensitive genes. 20/20