Matthew J. Webber
@WebberLab
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The Supramolecular Engineering Lab Notre Dame Dept. of Chemical and Biomolecular Engineering
Notre Dame, IN
Joined November 2015
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Happy and honored to announce that on July 1 I will be promoted to Associate Prof. w/ Tenure at Notre Dame
@NDCBE
!
Now, ~4.5 years after starting the Webber Lab at Notre Dame, a lot has changed.
A brief thread of gratitude and insight follows here. [1/8]
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Very excited to share that our lab has been awarded an
@NSF
CAREER Award! Our proposal is entitled "Dissipative Non-Equilibrium Supramolecular Hydrogels Using Fuels"
(A short thread about this proposal follows for those interested) [1/6]
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Very excited to learn our NIH R35 MIRA was selected for funding! Looking forward to advancing various biomaterials & drug delivery platforms.
With this arises an opening for a postdoc in the area of biomaterials & drug delivery. Send inquiries via email.
(RTs Appreciated)
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Postdoc hiring efforts of 2022 have netted the addition of (-3) postdocs to the team… we’re therefore still looking for candidates with expertise in small molecule, polymer, supramolecular, or systems chemistry. Email me application materials. Referrals very welcome.
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One major struggle for academics with kids that no one talks about: the need to vacuum your car for 20 minutes before you can drive a visitor somewhere.
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6 desk-rejections in one month. 5 of 6 places offered immediate review at their brand new OA "Sister Journal" (APCs ~$3-6k). Is this the future of academic publishing?
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New Year, New Title. Beginning today I’m the Keating-Crawford Collegiate Professor of Engineering. Thanks to Dean Culligan (
@NDengineering
) and my
@NDCBE
colleagues for this honor.
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Sad to see that chemistry is so scary, but how about those prices!
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Happy to share a review written with
@mtibbitt
on "Dynamic and reconfigurable materials from reversible network interactions" published today in
@NatRevMater
! Check out our perspective on the unifying features and possibilities of dynamic soft materials.
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Happy to share the newest paper from our lab by grad student Bo Su and team out this week in
@angew_chem
on "Transient and Dissipative Host–Guest Hydrogels Regulated by Consumption of a Reactive Chemical Fuel" A brief 🧵 follows here [1/4].
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Thanks to
@acspmse
for the very nice plaque! Would have loved to join the other honorees for a fantastic symposium at next month’s
@AmerChemSociety
meeting, but virtual will have to do.
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Excited to have my first grad student
@M_A_VandenBerg
's paper published in ACS Nano! "Divergent Self-Assembly Pathways to Hierarchically Organized Networks of Isopeptide-Modified Discotics under Kinetic Control" (a paper-themed thread follows)
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It’s an honor to have been elected by my peers to the
@aimbe
College of Fellows. As the first Fellow from
@NotreDame
I look forward to connecting our University with this great organization in advocating for sustained biomedical research in the US.
@NDengineering
@NDCBE
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Happy to share our newest paper, led by graduate student Rachel Ollier, on the topic of "Biomimetic Strain-Stiffening in Fully Synthetic Dynamic-Covalent Hydrogel Networks" out today in
@ChemicalScience
! (). Also
@Webberlab
paper💯. A thread follows.[1/4]
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Example of peer review at it’s very best. Reviewer suggested a cool idea to do patterning with our hydrogels and it worked beautifully. Thank you anonymous friend! Be like Reviewer
#1
!
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The
@WebberLab
are looking for talented chemists with skills in the areas of materials, supramolecular, pharmaceutical, or systems chemistry. Need to fill multiple postdoc positions in ongoing projects. Please contact Prof. Webber with your interest. RTs appreciated.
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Matthew Webber selected as director of Notre Dame’s Berthiaume Institute for Precision Health
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First in-person lecture in the books and ~40 more to go... underestimated how hot it gets under this mask with a full hour of talking.
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The
@WebberLab
at Notre Dame is actively looking to hire multiple postdoctoral researchers or senior scientists. Please check our group website for Prof. Webber's contact details: . RTs appreciated. Referrals from friends also very welcome.
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Excited to share Hannah's (
@katnip_yu
) publication in
@J_A_C_S
! "Glucose-Fueled Peptide Assembly: Glucagon Delivery via Enzymatic
Actuation" Paper here, and thread that follows [1/6]
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Excited to announce that we have received a nice award
American Diabetes Association® Names Three Awardees for $4.875 Million in 2019 Pathway to Stop Diabetes Research Grants: American Diabetes Association®
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The
@WebberLab
is looking to hire multiple postdocs in the area of combinatorial systems chemistry, with an emphasis on dynamic covalent systems and enzymatically driven systems. Friends from
@syschem21
@ChemSystemsChem
communities welcome. RTs appreciated.
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Still looking. If you’re a chemist looking for a new postdoc experience at the intersection of supramolecular chemistry and biomedicine, please let me know.
Postdoc hiring efforts of 2022 have netted the addition of (-3) postdocs to the team… we’re therefore still looking for candidates with expertise in small molecule, polymer, supramolecular, or systems chemistry. Email me application materials. Referrals very welcome.
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Happy to share our latest thoughts on the topic of "Supramolecular 'Click Chemistry' for Targeting in the Body" authored by Christopher Addonizio and Brant Gates and out today in
@BioconjChem
! Especially proud of the figures on this one!
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Big news for
@WebberLab
today with Four(!) GRFPs awarded. Current grad students Emily DeWolf & Connor Schmidt and current/former undergrads Jackson Vyletel & Mark Legendre were awarded GRFP with Nicole Rose Lukesh being honorable mention. Congrats all!
@NDCBE
#ProudAdvisor
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Arrived at ND 4 years ago today... a lot has changed since this pic. Added many outstanding members and learned how to teach & run a lab. I have learned significantly more in my second 4-year stint at ND than I did in my first (BS ‘06
@NDCBE
)
The Webber Lab opens in world-class McCourtney Hall! Great things in store for ND CBE!
@NDengineering
@UNDResearch
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New paper from Lei Zou and the
@WebberLab
team entitled "Supramolecular Hydrogels via Light-Responsive Homoternary Cross-Links" in Biomacromolecules
@MacroJrnls_ACS
. We show a homoternary CB[8]–azobenzene motif for reversible light-responsive hydrogels.
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11
104
Happy to share new paper by Sisi, Mike, and others in
@WebberLab
on "Glucose-Responsive Injectable Thermogels via Dynamic-Covalent Cross-Linking of Pluronic Micelles" out today in
@ACSBiomaterials
. Congrats to the team! A brief thread follows here [1/4]
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Honored to have received the
@3M
Non-Tenured Faculty Award. I look forward to continuing to advance the relationship between this great and innovative company and
@NotreDame
.
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New
@WebberLab
paper by
@ZhouYeLab
@Xiang50857883
and other lab members out in
@MacroJrnls_ACS
"Polymeric Microneedle Arrays with Glucose-Sensing Dynamic-Covalent Bonding for Insulin Delivery" Mini-thread here [1/3]
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Congrats to
@WebberLab
’s first ever PhD awardee, Dr Adam Braegelman, who defended today. Adam was a steady source of leadership from our earliest days, authoring 8(+) papers and helping to build our CB research team. We’ll certainly miss him!
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Happy to share the commercial on our work that will air during two nationally televised Notre Dame football games this Fall. Honored to have our work on glucose-responsive glucagon featured in this piece alongside an inspiring young family.
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After a several year hiatus, it was great to get back to an annual
@WebberLab
gathering at our house. Even got to dust off one of my smokers for the occasion!
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A year following lab shutdown, and while finishing up two semesters of in-person teaching, I'm happy today to join Team Moderna! Though I was not personally in the RNA-LNP realm of the Langer Lab, to see (and receive) the impact of this technologies is very inspiring.
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Socially distanced farewell for the first member of the
@webberlab
Dr. Lei Zou, who leaves us to begin a faculty position in Tianjin. Lei brought CB and polymer chemistry to our lab and led several of our key early studies. Almost 4 years later, he’s off. We’ll miss him.
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Congratulations to
@WebberLab
's Adam Braegelman and co-authors for their paper "Macromolecular Solute Transport in Supramolecular Hydrogels Spanning Dynamic to Quasi-Static States" published today in
@ACS_ABM
! A brief thread follows here. [1/3]
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Moderna co-founder Robert Langer: ‘I wanted to use my chemical engineering to help people’
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Thanks to
@ASEE_DC
for award of the 2024 Curtis McGraw research award! Happy to represent
@NDCBE
@NDengineering
@UNDResearch
and have the
@WebberLab
’s research recognized.
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Positions still available. Please connect if you know someone looking for a postdoc in the areas of supramolecular chemistry, soft materials, and/or drug delivery.
The
@WebberLab
at Notre Dame is actively looking to hire multiple postdoctoral researchers or senior scientists. Please check our group website for Prof. Webber's contact details: . RTs appreciated. Referrals from friends also very welcome.
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Happy to share a paper co-led by Yuanhui Xiang and Sijie Xian entitled "Diboronate crosslinking: Introducing glucose specificity in glucose-responsive dynamic-covalent networks" published in
@JCRnEDITORS
. A thread follows here.[1/4]
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Three years ago today, the
@webberlab
opened at Notre Dame! We’ve grown a bit since this picture (both in number of people and PI weight). Honored to get to work with such a great team!
The Webber Lab opens in world-class McCourtney Hall! Great things in store for ND CBE!
@NDengineering
@UNDResearch
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Lei's new paper "Reversible hydrogel dynamics by physical–chemical crosslink photoswitching using a supramolecular macrocycle template" out today in Chemical Communications
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Check out our recent News & Views in
@NatureMaterials
highlighting the recent paper from
@OScherman
&
@ZehuanH
. The title of our piece "Dynamic soft materials as tough as glass"
Paper:
N&V:
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Happy to share the newest paper from the
@WebberLab
led by former postdoc
@ZhouYeLab
, out today in
@ACSMatLett
entitled "Detachable Microneedles via Host–Guest Supramolecular Polymer Networks." A brief 🧵 follows here [1/3]
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The Webber Lab presents its contribution to the 2020 Systems Chemistry Virtual Poster Session: "Dynamic Soft Materials from Tunable Supramolecular Recognition"
@syschem20
#syschemposter
#dynamic
Per the symposium guidelines, a thread follows [1/10]
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The lab gathered for a nice meal to mark the end of 2021 and welcome many new faces to the team since our last gathering. Looking forward to great things in 2022.
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Great to have old friend
@AppelGroup
in town for an engaging and comprehensive
@NDCBE
seminar today on dynamic, shear-thinning hydrogels. Polymer physics to COVID vaccines in 50 minutes!
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Fun writing a
@ScienceMagazine
perspective "Less is more when forming gels by dilution" on work from Bert Meijer and colleagues describing their gel-sol-gel-sol dilution cascade by orthogonal self-assembly motifs.
Perspective:
Paper:
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Happy to share our publication in Advanced Materials (
@AdvSciNews
) entitled "Insulin–Dendrimer Nanocomplex for Multi-Day Glucose-Responsive Therapy in Mice and Swine" demonstrating our newest platform for long-lasting AND glucose-responsive insulin [1/4]
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Happy to share the latest
@WebberLab
paper from Rachel Ollier on "Strain-Stiffening Mechanoresponse in Dynamic-Covalent Cellulose Hydrogels" that builds on our work to understand strain-stiffening in dynamic-covalent gels. A very detailed effort here!
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Happy to share our latest work by
@SihanYu_
@ZhouYeLab
and a great team published today in Advanced Materials
@AdvSciNews
entitled "Glucose-Triggered Gelation of Supramolecular Peptide Nanocoils with Glucose-Binding Motifs" [1/4]
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After over a year of planning, the
@WebberLab
is on the move! Thanks to
@UNDResearch
and
@NDCBE
for supporting our research efforts. We’re looking forward to brand new space to keeping growing into.
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Family fun to celebrate women in engineering at the
@ndwbb
game. Future engineers?
#GirlDad
@NDCBE
@NDengineering
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Very excited for Lei's new paper, published today in
@ACSCentSci
, where we have demonstrated a targeting paradigm of host–guest affinity for spatial localization of small molecule drugs. Funded by
@UNDResearch
and a seed grant from
@AmericanCancer
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Matt Sis continues the
@WebberLab
publication streak with his paper "Energy Landscapes of Supramolecular Peptide–Drug Conjugates Directed by Linker Selection and Drug Topology" out today in
@acsnano
! A brief thread follows here.[1/4]
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New paper from grad student Sijie "Sisi" Xian on "Temperature-Responsive Supramolecular Hydrogels" published in
@JMaterChem
B. Nice job, Sisi!
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Kindergarten Professor, Day 1. Expecting my worst course evals ever with this one.
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The
@WebberLab
is wrapping up a great year, getting things back on track after some tough COVID times. Very proud of this crew for persevering. 13 papers published this year & 7 trainees moving on to their next destinations (including our first 2 PhDs!). Cheers to 2023!
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After a big team effort over the last week, we’re now settled into the new space!
After over a year of planning, the
@WebberLab
is on the move! Thanks to
@UNDResearch
and
@NDCBE
for supporting our research efforts. We’re looking forward to brand new space to keeping growing into.
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First time at the
@NSF
reviewing proposals. Equal parts encouraging and discouraging; so many great ideas, but limited resources for support. The US needs a strong investment in Science to continue being leaders in innovation.
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Preparing my syllabus and noting I'm teaching in the highest density classroom I've ever had. This with no campus requirement for masking or surveillance testing. University admins act like the COVID war is over, but faculty with kids <12 are still in the thick of it.
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Great time visiting
@JHU_ChemBE
to meet with my dear old friend
@Honggangcui
and discuss science. Thanks so much for the invitation to present a seminar! It’s been too long since I’ve seen this awesome guy in real life.
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Happy to share the latest paper from the lab by Brant Gates on "Multivalent Cucurbituril Dendrons for Cell Membrane Engineering with Supramolecular Receptors" published today in
@BioconjChem
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Lei's new paper published today in
@ACS_AMI
on an exciting new line of research in our growing lab -- "Dynamic Supramolecular Hydrogels Spanning an Unprecedented Range of Host–Guest Affinity"
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Excited to have been included in the
@RSC_MolEng
list of "2020 Emerging Investigators" along with many friends, collaborators, and
@NDCBE
colleagues Profs. Yamil Colon and Ruilan Guo!
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Curious trend: 3 straight postdocs accepted positions and then “resigned” a matter of weeks (or less) before their scheduled start dates. Never had this happen before, and now 3 straight in under a year. Anyone else seeing this?
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The
@Webberlab
has an opening for a postdoc interested in the application of materials chemistry to the design of new soft materials and technologies for drug delivery. RTs appreciated.
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Hey
@ElsevierConnect
, how hard is it to have a universal login for Editorial Manager for all of your journals? Am I the only one who needs to reset their password every time I review a paper?
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Congrats to the
@WebberLab
’s 5th PhD,
@SihanYu_
, who defended her stellar PhD work today! Hannah led our groups glucagon work and had a number of nice papers, including two this year: (Adv Mat) & (JACS). Congrats Hannah! 🎉🎉🎉
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En route to
#AIChEAnnual
. Two years since my last in-person conference. I’m all smiles, I assure you… 😷
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Excited for
@NDCBE
to host Prof. Kristi Anseth (
@AnsethGroup
), who will receive the 2021 Reilly Lectureship Award from our department, with seminars this week on Monday 4:00 and Tuesday at 12:30.
1
11
57
Lei's newest paper online in
@Biomac_ACS
"Temperature-Responsive Supramolecular Hydrogels by Ternary Complex Formation with Subsequent Photo-Crosslinking to Alter Network Dynamics"
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Congrats to the
@Webberlab
’s Dr. Michael VandenBerg (
@M_A_VandenBerg
) founding lab member and the labs 2nd PhD graduate, defending today. Mike co-authored 13(+) publications during his PhD and helped build our team. We’ll miss him! (Bonus photo of the groups first-ever meeting)
1
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Had a great day at
@TUeindhoven
visiting with
@dankerslab
@P_Dankers
Bert Meijer and many others at the Institite for Complex Molecular Systems. Fun to learn about the great work going on and share some of the
@WebberLab
’s work as well!
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Celebrating the first annual
@WebberLab
Chinese New Year party! Thanks to party planning commissioners Hannah and Sisi!!
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1
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Happy to share our latest
@WebberLab
@NDCBE
publication led by
@ZhouYeLab
out today in
@AdvSciNews
Advanced Functional Materials on "Implications of Supramolecular Crosslinking on Hydrogel Toughening by Directional Freeze-Casting and Salting-Out" [1/3]
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I never thought I’d say this, but I miss when
#AcademicTwitter
consisted mostly of people bragging about: how many hours they work and/or their Jedi skills in work-life balance and/or their non-toxic and inclusive lab/dept/university...
0
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The
@WebberLab
minted it’s 3rd PhD today, Dr Christopher Addonizio! We were glad to celebrate Chris’s accomplishments over the years to advancing the synthesis and characterization of our host-guest motifs.
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Paper rejected after 6+ weeks under review; only one review received with limited substance. 3h later, same journal asks me to review something within 10 days?! For-profit publishers ask a lot of young faculty with limited reciprocity. Reconsidering my position on pre-prints...
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Did you (or someone you mentor) have a change of plans or job prospects? Graduating mid-year and want a head-start on your PhD?
@NDCBE
is now accepting PhD applications for a January start. GRE not required. Deadline October 1.
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Many positions still available. Seeing many graduations out there. If you’re looking for your next opportunity, please let me know.
The
@WebberLab
are looking for talented chemists with skills in the areas of materials, supramolecular, pharmaceutical, or systems chemistry. Need to fill multiple postdoc positions in ongoing projects. Please contact Prof. Webber with your interest. RTs appreciated.
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A great day resuming our annual ND-Purdue Soft Matter & Polymers Symposium. Special thanks to Heidi (
@NDnano
) and Barb (
@NotreDameEnergy
) for hard work to make this event happen! And to
@leal_prof
for delivering an awesome Keynote. And big congrats to these poster winners!
1
0
51
Congrats to
@AppelGroup
, and especially to first author Caitlin Maikawa, for this impressive demonstration of a supramolecular excipient to stabilize insulin and pramlintide co-formulations! Major implications for better diabetes therapy!
2
3
51
It was great to re-engage with my
@SFBiomaterials
community over the past few days and reunite with many colleagues. Thanks
@thechowlab
@pashucklab
@ZhaLabRPI
@GormleyLab
@BrudnoLab
@GregHudalla
@BurdickLab
@DrMTeplensky
@veiseho
@BrianAguado
@kjmchugh1
@Derfogail
+ so many more!
8
3
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We had an awesome week at the Peptide Materials GRC this week. Matt Sis and Hannah Yu had great posters and we got a Stupp group reunion picture as well. Thanks to
@Honggangcui
and Matt Tirrell for organizing an amazing event!
0
1
51
Closing out the week with the 4th PhD awarded from the
@WebberLab
to Dr. Matt Sis! We enjoyed hearing about his contributions to improving understanding of supramolecular peptide-drug conjugates. Congrats!
0
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The
@WebberLab
's first adventure into the world of preprints is posted today on
@ChemRxiv
"Insulin–Dendrimer Nanocomplex for Multi-Day Glucose-Responsive Therapy in Mice and Swine"
2
3
50
Today the
@Webberlab
is celebrating the departure of postdoc
@TengChi9
for a new job in CA, successful MS defense of Brant Gates, and
@NDCBE
seminar/best paper award of
@SihanYu_
! Many congrats to all!
0
0
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Awesome to have
@RosalesGroup
here for an
@NDCBE
seminar. Beautiful and elegant work on molecular-scale design of dynamic soft materials!
0
1
48
Congrats to
@mtibbitt
and colleagues on this great work. "Supramolecular Reinforcement of Polymer–Nanoparticle Hydrogels for Modular Materials Design"
1
1
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Honored to be included among so many great people as a "2017 Emerging Investigator" by
@BioMaterSci
!
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It’s been another great academic year working with an awesome team! Thanks to this fantastic group for their dedication, energy, and creativity.
1
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Honored to be included in AIChE's 35 under 35! Thanks
@ChEnected
! Congrats to
@coledeforest
and
@ChungLabUSC
as well
9
7
47
Hannah's (
@katnip_yu
) recent
@J_A_C_S
paper () is featured as a supplemental cover in this week's issue! Thanks to
@sciencebrush
@hatahini
for the creative design work!
0
4
48
I can’t lay claim as many Oscar, Emmy, or Tony Awards as Viola Davis, but I’m happy to share in this honor. People to Know 2019: Diabetes Forecast®
2
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Congrats to
@WebberLab
undergrad Jackson Vyletel for completing and defending his undergraduate thesis. Jackson will be taking his
@NSF
GRFP award to UPenn for his PhD studies.
0
1
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