LaboratoryChemicalGlycobiology
@VocadloGroup
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Group ran account. Here to share research from the group and topics that peak our interest. While David is involved, tweets do not reflect his opinion.
Burnaby, BC, Canada
Joined December 2017
@NobelPrize Wonderful news - congratulations to all - transformative research! And best wishes to @CarolynBertozzi - brilliant scientist and amazing communicator - an inspiration!
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Check out our newest publication led by @MatthewDeen4 and @1981zyp! Herein, we report a new and improved fluorescence-quenched substrate, LysoFQ-GBA, to quantitatively monitor GCase activity in stem-cell derived neurons and PBMCs.
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Nice commentary on new CO2 protein carboxylation paper in NCB. This methods paper enables in vitro mimicry of CO2-protein carboxylation and high-throughput mapping of CO2-modified lysine residues. Inspired by pioneering work of @MartinCann1 and others.
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RT @DustinTKing: I am excited to announce that I will soon be starting as an assistant professor at SFU (July 18th). I am excited to be joi…
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A little late, but congrats to @raashmus for receiving an oral presentation award (2nd place) at SFU's 8th Annual Postdoc Research Day.
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The group welcomes visiting student Jun Bian from Josef Voglmeir's group at Nanjing University. She will work on an ongoing collaborative project around deacetylases.
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Nice work in ACS Chemical Biology from the Chen team on optimized methods for high-throughput mapping and quantifying of O-GlcNAc. #glycotime
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The group welcomes Nita Lu, a recent graduate from UofT. She will gain some research experience in developing and evaluating novel glycosidase substrate probes in vitro.
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Part of the group having a going away lunch for Viktor at BierCraft UniverCity.
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@chembiokevin @J_A_C_S That noted. Data tables in SI enable exploration. The quadruplicate erPTM-TPP data is the most robust. If mining for data, suggest starting there and then going to the other data sets. Loosening the stringency would expand the scope but would need to be carefully done.
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Cool new observation: sugaring out of proteins - not caused by glycation. Could open new avenues for research into physiologic effects of high glucose | ACS Chem Biol.
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Fibrils of a fragment TMEM106B discovered in multiple neurodegenerative diseases - a potential important commonality. Great use of cryoEM.
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The destabilizing effects found using PTM-TPP for O-GlcNAc are likely mediated by influencing protein complexes. Nice team work with @jesus_esn and Yan as well as Christopher and M Shoulders (MIT) and L Foster (UBC). Hope the methods will be useful for exploring other PTMs.
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Interesting paper. Metabolic tolerance of sialic acid pathway - Boltje team provides insight into metabolic labeling and metabolic inhibitors of sialylation.
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The work would be delayed further without the huge support from Pierre, Xi 'Kelly', Matt, Sha, Xiaoyang, and Christina in the group as well as Yang from the @BrittonLab for the preparation of inhibitors.
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