The Twinkle Factory
@TwinkleFactory1
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At The Twinkle Factory, we enjoy colorful, fluorescent, blinking, life sciences! Stain Different. Tag FAST.
Paris, France
Joined September 2020
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simple - powerful - congrats!!!
We made a crucial step towards point-of-care
#diagnostics
of
#cancer
based on our light-harvesting
#nanoparticles
for enzyme-free amplified detection of cellular
#microRNA
. Congrats and thanks to all co-authors!
@unistra
@CNRS
@ERC_Research
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🌈 Leveraging FAST of The Twinkle Factory with click chemistry for à-la-carte fluorescent reporting in microbiome! Let them introduce Click-FAST, tfPoppy-alkyne, plBlaze-alkyne 🍭
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browse Addgene base for recent improvements of
#FAST
and
#splitFAST
, e.g., the latest promiscuous pFAST
A set of spectrally orthogonal fluorogen-activating fluorescent tags, greenFAST and redFAST, are compatible with two-color, live-cell imaging are now available from Arnaud Gautier's lab!
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Prof.
@LudovicJullien2
introducing FAST at FBI-AT 2022 at
@institut_curie
After the introduction by Rene Marc Mège on
@Fr_BioImaging
, the first session
#FBIAT2022
was exceptional with
@JoergBewersdorf
, Judith Mine Hattab, Ludovic Jullien and Nicolas Borghi
@IJMonod
🔬
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Finally published in Nat. Commun. Two new products launched: tfDart, a dark (!) chromophore, & tfFox-NP, an ultra-bright non-membrane permeant fluorogen
"An engineered multifunctional protein tag for advanced fluorescence imaging
Hela Benaissa et al.
bioRxiv. posted 31 January 2021, 10.1101/2021.01.29.428635
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There are a lot of options for split fluorescent proteins - finding the right one can be challenging in a sea of choices! Check out our recent blog post to see some of the newest and most popular split fluorescent proteins in our repository.
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🌈plasmids now available at
@addgene
🍭
Very happy to share a new approach we developed at
@institut_curie
/
@CNRS
with my colleague and friend Arnaud Gautier from
@Sorbonne_Univ_
/
@ENS_ULM
CATCHFIRE allows to induce and sense protein interaction using a reversible fluorogenic system. More here :
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🌈 Already a standard for fluorescent reporting in anaerobes, FAST of The Twinkle Factory is gaining the high-temperature zone! 🍭
New Research: A fluorescent reporter system for anaerobic thermophiles
#bioengineering
#biotech
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@rosscloney
@claudiaevickers
Congrats
@claudiaevickers
et al. Incidentally, a nice proof of concept of FAST in Saccharomyces!
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Congrats team on the powerful tool! Happy to help with FAST
Introducing HapAmp, an in vivo gene amplification system that exploits haploinsufficiency to amplify copy number and deliver high level expression. 20-fold increase in monoterpene titre in a single engineering step!
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🌈 check
@TwinkleFactory1
for updates 🍭
Connaissez-vous Twinkle factory? Cette jeune entreprise est née
@ENS_ULM
et
@institut_curie
, au sein de
@psl_univ
, et propose des outils uniques pour l’imagerie de fluorescence. Suivez cette aventure initiée, dans notre département, par Arnaud Gautier et Ludovic Jullien.
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Comprehensive wrap-up of protocols for
#FAST
and
#splitFAST
engineering in Yeast Surface Display of the Molecular Biology Protocols series by Lina El Hajji, Hela Benaissa, and Arnaud Gautier
@Sorbonne_Univ_
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🌈 and fluorogenic molecular glues for CATCHFIRE are available at 🍭
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🌈🌈 Stay tuned! Check our newsflow, scientific articles implementing
#FAST
and
#splitFAST
, and
#CATCHFIRE
, fluorogenic reagents release, labels, molecular glues 🍭🍭
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Back to basics :( Merci
@BIRDlab_ENS
Pour ma dernière carte blanche de la saison dans
@lemonde_science
, j'ai failli parler de la biologie du virus...
Et puis non.
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🌈 Congrats
@redoxgeek
(Kyle Costa of Uni-Minnesota) on the first implementation ever of
#FAST
and
#splitFAST
of The Twinkle Factory in
#Archaea
🍭
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🌈 happy to share there our experience with
@Fr_BioImaging
🍭
Find out how
@EuroBioImaging
Nodes and imaging facilities bring collaborations with industry to life, how they work on a daily basis and how to build lasting partnerships!
Register for our webinar on October 28th at 10am CEST
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🌈 second application of FAST of The Twinkle Factory in Archaea within weeks! Congrats Norman Adlung and Silvan Schiller of
@AaltoUniversity
🍭
Application of the fluorescence-activating and absorption-shifting tag (FAST) for flow cytometry in methanogenic archaea.
#bioRxiv
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