TimePie (focus on anti-aging science)
@TimePieChina
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@TimePieChina focuses on aging science & longevity news. We would love to be the bridge to academic circle of aging in China. #aging #longevity #senescence
China
Joined January 2022
A panoramic view of cell population dynamics in mammalian #aging: By Zehao Zhang, Wei Zhou, Junyue Cao, et al.from @RockefellerUniv
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A new study indicates that Exo-srIκB is a potent anti-inflammatory therapeutic agent that promises to delay brain #aging and treat neurodegenerative diseases.
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Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis.
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A new study shows menopause-associated senescence and extracellular matrix disassembly in the sex-specific pathogenesis of knee osteoarthritis. By @gabbygilmer, Christopher H. Evans, PhD of @MayoClinic, Fabrisia Ambrosio, PhD of @SpauldingRehab, et al.
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New Research Reveals Common Drug Could Make Your Brain Age Faster It shows the removal of metabolic waste from the brain is impaired by the pharmaceutical sleep-aid drug zolpidem in mice.
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New Potential Hair Regrowth Agent Targets Hallmarks of Aging. A study shows the plant-based compound isoquercitrin promotes hair regrowth by targeting hallmarks of aging — biological drivers of aging — in rats.
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SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.
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New study suggests drinking 1 to 3 cups of coffee in the morning is linked to a 16% lower risk of all-cause mortality and a 31% lower risk of cardiovascular mortality.
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A new study about #NR supplementation: It finds 8 weeks NR supplementation lowered pTau217 concentrations but did not alter cognition as measured by conventional or novel digital assessments.
mild cognitive impairment is a hard, hard problem for fans of biomarkers, NR significantly depressed phosphoTau for fans of physical activity, NR increased step count in this population sadly, no improvement in cognitive function in 8 wk trial
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A new study shows, dietary cinnamon promotes #longevity and extends #healthspan via mTORC1 and autophagy signaling.
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Intermittent fasting (IF) improves metabolic health in some individuals but increases health risks in others. @LeonardoMatta, @BarteltLab, et al. show that IF oppositely affects β cells depending on age: beneficial at old but deleterious at young age.
Today, we report that chronic intermittent fasting impairs beta-cell maturation & function in adolescent mice. Using scRNAseq, we delineated a maturation score for beta-cells. Long-term good if you're older, might be harmful if you are still developing! 👇
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@OpenAI has created an AI model for #longevity science: GPT-4b micro. The company is making a foray into scientific discovery with an AI built to help manufacture stem cells.
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@PatelCardio Looking forward to more research on this. There’s been a study on how environmental temperature affects cardiovascular health, which could be super relevant.
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Air pollution and brain damage: what the science says？ Epidemiological studies have linked dirty air to dementia and other brain disorders. Now researchers are trying to determine how pollutants do their damage, and how much harm they cause.
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Drinking tea every day is proven to delay biological aging in humans.
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In a preprint study, scientists from @LifespanRI & @BuckInstitute published their findings that #Urolithin A, a molecule that has garnered a lot of attention in the longevity field, potently reduces #senescence-related markers in human fibroblasts.
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Rubedo Life Sciences(@LifeRubedo)announces clinical development plans for lead candidate RLS-1496, a first-in-class GPX4 modulator targeting #aging cells and surrounding tissues.
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People who eat more red meat, especially processed red meat like bacon, sausage, and bologna, are more likely to have a higher risk of cognitive decline and dementia compared to those who eat very little red meat, according to a new study.@HarvardEpi
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